Copper-catalyzed oxidative amidation of aldehydes with amine salts: Synthesis of primary, secondary, and tertiary amides

…, AM Seayad, DT Tuan, CLL Chai, A Chen

文献索引：Dang, Tuan T.; Zhu, Yinghuai; Ghosh, Subhash C.; Chen, Anqi; Chai, Christina L. L.; Seayad, Abdul M. Chemical Communications, 2012 , vol. 48, # 12 p. 1805 - 1807

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被引用次数: 104

摘要

A practical method for the amidation of aldehydes with economic ammonium chloride or amine hydrochloride salts has been developed for the synthesis of a wide variety of amides by using inexpensive copper sulfate or copper (I) oxide as a catalyst and aqueous tert-butyl hydroperoxide as an oxidant. This amidation reaction is operationally straightforward and provides primary, secondary, and tertiary amides in good to excellent yields for most ...