Intramolecular ureido and amide group participation in reactions of carbonate diesters

SW King, R Natarajan, R Bembi…

文献索引：King, Stephen W.; Natarajan; Bembi, Ramesh; Fife, Thomas H. Journal of the American Chemical Society, 1992 , vol. 114, # 27 p. 10715 - 10721

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被引用次数: 8

摘要

Conclusions The kinetic data indicate that phosphorothiolates bearing a center of asymmetry at phosphorus differ in their postinhibitory mechanisms and their inhibitory potency. Despite the greater sensitivity of RBAChE toward inactivation by 2a-, the RBAChE could recover from poisoning by this stereoisomer. Conversely, RBAChE phosphorylated by 2a+ may be more susceptible to a cumulative inactivation, owing to inability of the enzyme ...