Chemistry–A European Journal

Sulfinylnitriles: Sulfinyl–Metal Exchange–Alkylation Strategies

D Nath, FF Fleming

文献索引：Nath, Dinesh; Fleming, Fraser F. Chemistry - A European Journal, 2013 , vol. 19, # 6 p. 2023 - 2029

全文：HTML全文

被引用次数: 7

摘要

Abstract Adding organolithiums, Grignard reagents, or zincates to sulfinylnitriles triggers a facile sulfinyl–metal exchange to afford N-or C-metalated nitriles. Sulfinyl–magnesium exchange–alkylations efficiently install quaternary and tertiary centers, even in the case of tertiary sulfinylnitriles that contain a highly acidic methine proton. α-Sulfinylalkenenitriles afford moderately nucleophilic magnesiated nitriles, and the reactivity can be dramatically ...