富马酸卢帕他定
更新时间：2025-08-27 08:07:10
| 常用名 | 富马酸卢帕他定 | CAS号 | 182349-12-8 |
|---|---|---|---|
| 价格 | ￥需询单/10000mg ￥需询单/100g | 纯度 | 99.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in human platelet-rich plasma (HPRP) (IC50 = 0.68 microM), while not affecting ADP- or arachidonic acid-induced platelet aggregation [1]. The IC50 for rupatadine in A23187, concanavalin A and anti-IgE induced histamine release was 0.7+/-0.4 microM, 3.2+/-0.7 microM and 1.5+/-0.4 microM, respectively whereas for loratadine the IC50 was 2.1+/-0.9 microM, 4.0+/-1.3 M and 1.7+/-0.5 microM. SR-27417A exhibited no inhibitory effect [2].in vivo: Rupatadine blocked histamine- and PAF-induced effects in vivo, such as hypotension in rats (ID50 = 1.4 and 0.44 mg/kg i.v., respectively) and bronchoconstriction in guinea pigs (ID50 = 113 and 9.6 micrograms/kg i.v.). Moreover, it potently inhibited PAF-induced mortality in mice (ID50 = 0.31 and 3.0 mg/kg i.v. and p.o., respectively) and endotoxin-induced mortality in mice and rats (ID50 = 1.6 and 0.66 mg/kg i.v.) [1]. rupatadine treatment improved the declined lung function and significantly decreased animal death. Moreover, rupatadine was able not only to attenuate silica-induced silicosis but also to produce a superior therapeutic efficacy compared to pirfenidone, histamine H1 antagonist loratadine, or PAF antagonist CV-3988 [3]. 物理化学性质： CAS号：182349-12-8 常用中文名：富马酸卢帕他定 常用英文名：Rupatadine Fumarate 分子式：C30H30ClN3O4 分子量：532.030 密度：N/A 沸点：586.4ºC at 760 mmHg 熔点：58-61ºC 闪点：308.4ºC 储存条件：Refrigerator |
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：富马酸卢帕他定
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：化源网
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：富马酸卢帕他定
- 价格： ￥348.0/50mg ￥1038.0/250mg
- 纯度：98.0%
- 备货期：2天
- 联系人：刘佳
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Rupatadine
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海脉铂医药科技有限公司
- 上海市 上海市 嘉定区
- 产品名：Rupatadine Fumarate
- 价格： ￥1559.0/500mg ￥829.0/100mg ￥989.0/1g ￥需询单/1g
- 纯度：98.0%
- 备货期：2天
- 联系人：李先生
- 上海阿摩尔生物科技有限公司
- 上海市 上海市 奉贤区
- 产品名：富马酸卢帕他定
- 价格： ￥需询单/100mg ￥需询单/1g ￥需询单/250mg ￥需询单/25g
- 纯度：98.0%
- 备货期：需询单
- 联系人：王汐瑶
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：富马酸鲁帕他定
- 价格： ￥396.9/1g ￥174.9/250mg ￥203.9/1ml ￥105.9/100mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：￥210.6/50mg