182349-12-8

• 常用中文名：富马酸卢帕他定
• 常用英文名：Rupatadine Fumarate
• CAS号：182349-12-8
• 分子式：C₃₀H₃₀ClN₃O₄
• 分子量：532.030
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) Histamine Receptor 抑制剂
• 发布时间：2018-08-24 10:38:50
• 更新时间：2026-07-16 21:15:24
• Rupatadine(UR-12592)富马酸盐是PAF/H1受体双效抑制剂,Ki值分别为0.55uM和0.1uM。

名称

• 中文名: 富马酸卢帕他定
• 英文名: Rupatadine Fumarate
• 中文别名: 化合物:Rupatadine Fumate; 化合物：Rupatadine Fumate; 8-氯-6,11-二氢-11-[1-[(5-甲基-3-吡啶基)甲基]-4-哌啶亚基]-5H-苯并[5,6]环庚烷并[1,2-b]吡啶富马酸盐; 8-氯-6,11-二氢-11-[1-[(5-甲基-3-吡啶基)甲基]-4-哌啶亚基]-5H-苯并[5,6]环庚烷并[1,2-B]; 富马酸鲁帕他定; Rupatadine Fumate富马酸卢帕他定; 富玛酸卢帕他定; 8-氯-11-(1-((5-甲基吡啶-3-基)甲基)哌啶-4-亚基)-6,11-二氢-5H-苯并[5,6]环庚[1,2-B]吡啶富马酸盐; 富马酸泸帕他; 富马酸泸帕他定; 富马酸卢帕他定,10 MM DMSO 溶液; mmu-miR-5135 mimicmmu-miR-5135 模拟物; 17-环氧孕烯醇酮醋酸酯
• 英文别名: 8-Chloro-11-{1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene}-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (2E)-but-2-enedioate (1:1); Rupatadine fumate - Bio-X; Rupatadine (Fumarate); RUPATIDINE FUMATE; Rupax FuMate; Rupatadine FumateQ: What is Rupatadine Fumate Q: What is the CAS Number of Rupatadine Fumate Q: What is the storage condition of Rupatadine Fumate Q: What e the applications of Rupatadine Fumate; Rupafin; Ningenin Impurity 19; 17-oxypregnenolone acetate; 8-Chloro-11-{1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene}-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (2E)-2-butenedioate (1:1); Rupatadine Fumate IP; Alergoliber FuMate; 13-chloro-2-{1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene}-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1,3,5,7,11,13-hexaene; UR12592 Fumate; Rupatadin Fumate; Rupatadine fumate; Rupatadine Fumate //BP; Rupatadine Fumate, 10 mM in DMSO; Rupatadine fumarate; Rinialer FuMate; 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohta[1,2-b]pyridine fumate; Pafinur FuMate; 5H-Benzo[5,6]cyclohta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-, (2E)-2-butenedioate (1:1); 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-, (2E)-2-butenedioate (1:1); 8-Chloro-11-(1-((5-methylpyridin-3-yl)methyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohta[1,2-b]pyridine fumate; Ralif; 17alpha-oxypregnenolone acetate; Rupafin FuMate; Rupatadine Fumic Acid; UR 12592 Fumate; UR-12592 Fumate; Rupatadine Fumate (UR-12592); (E)-but-2-enedioic acid,8-chloro-11-[1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene]-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine; 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidylidene]-5h-benzo[5,6]cyclohta[1,2-b]pyridine fumate

物化性质

• 沸点: 586.4ºC at 760 mmHg
• 熔点: 58-61ºC
• 分子式: C₃₀H₃₀ClN₃O₄
• 分子量: 532.030
• 闪点: 308.4ºC
• 精确质量: 531.192505
• PSA: 103.62000
• LogP: 5.28460
• 储存条件: Refrigerator

生物活性

• 描述: Rupatadine(UR-12592)富马酸盐是PAF/H1受体双效抑制剂,Ki值分别为0.55uM和0.1uM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21.

  [2]. Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60.

  [3]. Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631.

安全

• 危害码 (欧洲): Xi