N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲

更新时间：2025-08-21 17:50:03

N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲结构式	常用名	N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲	英文名	Ki20227
	CAS号	623142-96-1	分子量	480.536
	密度	1.3±0.1 g/cm3	沸点	621.8±55.0 °C at 760 mmHg
	分子式	C₂₄H₂₄N₄O₅S	熔点	N/A
	MSDS	N/A	闪点	329.8±31.5 °C

用途

Ki-20227是CSF1R抑制剂，IC50为2 nM，对VEGFR2的IC50为12 nM，对c-Kit/PDGFRβ的IC50则为451/217 nM。

中文名	N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N’-[1-(2-噻唑基)乙基]脲
英文名	1-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-methoxyphenyl]-3-[1-(1,3-thiazol-2-yl)ethyl]urea
中文别名	N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲
英文别名	更多

描述	Ki-20227是CSF1R抑制剂,IC50为2 nM,对VEGFR2的IC50为12 nM,对c-Kit/PDGFRβ的IC50则为451/217 nM。
相关类别	信号通路 >> 蛋白酪氨酸激酶 >> c-FMS 研究领域 >> 炎症/免疫
参考文献	[1]. Ohno H, et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther. 2006 Nov;5(11):2634-43. [2]. Ohno H, et al. The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model. Eur J Immunol. 2008 Jan;38(1):283-91. [3]. Uemura Y, et al. The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis. J Neuroimmunol. 2008 Mar;195(1-2):73-80. [4]. Boru Hou, et al. Ki20227 influences the morphology of microglia and neurons through inhibition of CSF1R during global ischemia. Int J Clin Exp Pathol. 2016;9(12):12459-12469.

描述

Ki-20227是CSF1R抑制剂,IC50为2 nM,对VEGFR2的IC50为12 nM,对c-Kit/PDGFRβ的IC50则为451/217 nM。

相关类别

信号通路 >> 蛋白酪氨酸激酶 >> c-FMS

研究领域 >> 炎症/免疫

参考文献

[1]. Ohno H, et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther. 2006 Nov;5(11):2634-43.

[2]. Ohno H, et al. The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model. Eur J Immunol. 2008 Jan;38(1):283-91.

[3]. Uemura Y, et al. The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis. J Neuroimmunol. 2008 Mar;195(1-2):73-80.

[4]. Boru Hou, et al. Ki20227 influences the morphology of microglia and neurons through inhibition of CSF1R during global ischemia. Int J Clin Exp Pathol. 2016;9(12):12459-12469.

密度	1.3±0.1 g/cm3
沸点	621.8±55.0 °C at 760 mmHg
分子式	C₂₄H₂₄N₄O₅S
分子量	480.536
闪点	329.8±31.5 °C
精确质量	480.146729
PSA	132.07000
LogP	4.18
InChIKey	SHPFDGWALWEPGS-UHFFFAOYSA-N
SMILES	COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1
蒸汽压	0.0±1.8 mmHg at 25°C
折射率	1.651
储存条件	2-8℃

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External Id：SNCA-p-activity-luciferase

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External Id：1805_Human

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External Id：ATLMIPE3-IL2

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1-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl}-3-[1-(1,3-thiazol-2-yl)ethyl]urea

hms3244k11

hms3244l11

hms3244k12

N-(4-((6,7-dimethoxy-4-quinolyl)oxy)-2-methoxyphenyl)-N'-(1-(1,3-thiazole-2-yl)ethyl)urea

Ki20227

N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲

用途

名称

生物活性

物理化学性质

靶点实验

英文别名

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