N-(4-氯-2-氟苯基)-6,7-二甲氧基-4-喹唑啉胺结构式
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常用名 | N-(4-氯-2-氟苯基)-6,7-二甲氧基-4-喹唑啉胺 | 英文名 | ZM 306416 |
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| CAS号 | 690206-97-4 | 分子量 | 333.745 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 434.1±45.0 °C at 760 mmHg | |
| 分子式 | C16H13ClFN3O2 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 216.4±28.7 °C |
用途ZM-306416 (CB 676475) 是 VEGFR 的有效抑制剂,对KDR 和 Flt的 IC50 值分别为0.1 和 2 μM。ZM-306416 也是 EGFR 的抑制剂,IC50 值小于10 nM。 |
| 中文名 | N-(4-氯-2-氟苯基)-6,7-二甲氧基-4-喹唑啉胺 |
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| 英文名 | N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine |
| 英文别名 | 更多 |
| 描述 | ZM-306416 (CB 676475) 是 VEGFR 的有效抑制剂,对KDR 和 Flt的 IC50 值分别为0.1 和 2 μM。ZM-306416 也是 EGFR 的抑制剂,IC50 值小于10 nM。 |
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| 相关类别 | |
| 靶点实验 |
KDR:100 nM (IC50) Flt-1:2 μM (IC50) |
| 体外研究 | ZM-306416对EGFR成瘾的NSCLC细胞系H3255和HCC4011的选择性抗增殖作用(IC50分别为0.09±0.007μM和0.072±0.001μM),同时保留了野生型EGFR细胞系A549和H2030(IC50>10μM) 。还发现ZM-306416抑制ABL体外激酶活性,对ABL激酶的IC50值较低,为1.3±0.2μM[2]。 |
| 参考文献 |
| 密度 | 1.4±0.1 g/cm3 |
|---|---|
| 沸点 | 434.1±45.0 °C at 760 mmHg |
| 分子式 | C16H13ClFN3O2 |
| 分子量 | 333.745 |
| 闪点 | 216.4±28.7 °C |
| 精确质量 | 333.068024 |
| PSA | 56.27000 |
| LogP | 4.15 |
| InChIKey | YHUIUSRCUKUUQA-UHFFFAOYSA-N |
| SMILES | COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC |
| 蒸汽压 | 0.0±1.0 mmHg at 25°C |
| 折射率 | 1.653 |
| 储存条件 | Desiccate at RT |
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| N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine |
| N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine |
| Anilinoquinazoline deriv. 4 |
| ZM-306416 |
| ZM306416 |
| ZM 306416 |