(Rac)-Rotigotinehydrochloride
更新时间：2024-07-15 12:29:46
采购访问：17次
| 常用名 | rac-Rotigotine Hydrochloride | CAS号 | 102120-99-0 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM. IC50 Value: 0.69 nM(Ki)Target: D-2 receptorin vitro: rac-Rotigotine showed high potency (Ki = 0.69 nM) and selectivity for D-2 receptors as compared to its potency and selectivity at various other neuronal receptors (Ki in nM): D-1 (678) dopamine, alpha 1-(534) and alpha 2-(195) adrenoceptor, S1-(6940) and S2-(5900) serotonin and muscarine (2660). Very low activity (Ki greater than 10(-5) M) was seen at the beta-adrenoceptor, A1-adenosine, GABAA and benzodiazepine receptors. Furthermore, rac-Rotigotine inhibited the calcium-dependent release of [3H]dopamine (IC50: 4 nM) and [3H]acetylcholine (IC50: 6.3 nM) from rabbit striatal slices in the nanomolar range. These effects of rac-Rotigotine were mediated through activation of D-2 dopamine autoreceptors and D-2 dopamine heteroreceptors, respectively.in vivo: Presynaptic dopaminergic activity in vivo was measurable as an inhibition of the locomotor activity of mice, and in this model rac-Rotigotine was more effective than apomorphine. Moreover, the effect of rac-Rotigotine could be antagonized by sulpiride but not by yohimbine. rac-Rotigotine was equipotent with apomorphine in inducing circling behaviour in 6-OHDA-lesioned rats. rac-Rotigotine had almost no serotonergic activity in vivo. 物理化学性质： CAS号：102120-99-0 常用中文名：rac-Rotigotine Hydrochloride 常用英文名：(Rac)-Rotigotine hydrochloride 分子式：C19H26ClNOS 分子量：351.93400 密度：N/A 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：2-8℃ |
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- 上海阿拉丁生化科技股份有限公司
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- 产品名：(Rac)-Rotigotine hydrochloride
- 价格： ￥2394.0/50mg ￥需询单/1g ￥需询单/1g ￥需询单/1g
- 纯度：97.0%
- 备货期：1天
- 联系人：阿拉丁
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- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：(Rac)-Rotigotinehydrochloride
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
351666998
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参考价格：$66/10mM*1mLinDMSO