102120-99-0

• 常用中文名：rac-Rotigotine Hydrochloride
• 常用英文名：(Rac)-Rotigotine hydrochloride
• CAS号：102120-99-0
• 分子式：C₁₉H₂₆ClNOS
• 分子量：351.93400
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 多巴胺受体
• 发布时间：2018-11-30 05:48:55
• 更新时间：2026-07-02 11:59:17
• rac-Rotigotine盐酸盐是D-2受体选择性激动剂,Ki为0.69 nM。

名称

• 中文名: 5,6,7,8-四氢-6-[丙基[2-(3-噻吩基)乙基]氨基]-1-羟基萘盐酸盐
• 英文名: rac-Rotigotine Hydrochloride
• 中文别名: 罗替高汀-D7盐酸; 消旋罗替戈汀; 化合物 (RAC)-ROTIGOTINE HYDROCHLORIDE; 盐酸罗替高汀; 罗替戈汀外消旋盐酸盐; 5,6,7,8-四氢-6-[丙基[2-(2-噻吩基)乙基]氨基]-1-萘酚盐酸盐; 化合物:rac-Rotigotine Hydrochloride; 化合物：rac-Rotigotine Hydrochloride; 罗替高汀消旋体
• 英文别名: (Rac) Rotigotine hydrochloride,(Rac)Rotigotine hydrochloride; rac-Rotigotine (Hydrochloride); 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (Hydrochloride) (1:1); Rotigotine Impurity 2（Rotigotine Racemate HCl）; Rotigotine-d7 HCl; Rotigotine Racemate HCl; 1-Naphthalenol,5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-,hydrochloride; 5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol Hydrochloride; N 0437 hydrochloride

物化性质

• 分子式: C₁₉H₂₆ClNOS
• 分子量: 351.93400
• 精确质量: 351.14200
• PSA: 51.71000
• LogP: 5.06770
• 储存条件: 2-8℃

生物活性

• 描述: rac-Rotigotine盐酸盐是D-2受体选择性激动剂,Ki为0.69 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Rocchi C, Pierantozzi M, Pisani V, Marfia GA, Di Giorgio A, Stanzione P, Bernardi G, Stefani A.The Impact of Rotigotine on Cardiovascular Autonomic Function in Early Parkinson's Disease.Eur Neurol. 2012 Aug 28;68(3):187-192.

  [2]. Wang A, Wang L, Sun K, Liu W, Sha C, Li Y.Preparation of Rotigotine-Loaded Microspheres and Their Combination Use with L-DOPA to Modify Dyskinesias in 6-OHDA-Lesioned Rats.Pharm Res. 2012 Sep;29(9):2367-76.

  [3]. Belluzzi et al (2004) N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov.disord. 9 147.

  [4]. Scheller et al (2009) The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn.Schmiedebergs.Arch.Pharmacol. 379 73.

  [5]. Oertel W, Lewitt P, Giladi N, Ghys L, Grieger F, Boroojerdi B.Treatment of patients with early and advanced Parkinson's disease with rotigotine transdermal system: Age-relationship to safety and tolerability.Parkinsonism Relat Disord. 2012 Sep 3.

安全

• 海关编码: 2934999090

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%