长春氟宁
更新时间：2024-07-15 12:32:40
采购访问：20次
| 常用名 | 长春氟宁 | CAS号 | 162652-95-1 |
|---|---|---|---|
| 价格 | 纯度 | 98.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.Target: Microtubule/TubulinThe major effects of Vinflunine on dynamic instability are a slowing of the microtubule growth rate, an increase in growth duration, and a reduction in shortening duration. The effects of Vinflunine on the readmilling rate is examined by following [3H]GTP incorporation into MAP-rich microtubules, and the IC50 is 0.42 μM [1]. Vinflunine induced mitotic accumulation with IC50 with 18.8 nM, which decreases the centromere dynamicity by 44% and increases the time centromeres spent ina paused state by 63% [2]. Treatment of Vinflunine induces a rapid change in endothelial cell shape: cells retracts and assumes a rounded morphology. Mean IC50 values are 9.9 × 10-5 M × 10-5 M for fibronectin and 5.0× 10-5 M × 10-5 M for type IV collagen. A short 4 hours exposure of endothelial cells to Vinflunine at 10-8 0.05). An ID50 value (dose which inhibits 50% of bFGF-induced neovascularisation) is calculated as 1 mg/kg. Low doses of Vinflunine reduce the number of experimental liver metastases by human LS174T colon cancer cell. A slight overall decrease in liver metastatic foci is already observed at the very low dose of 0.16 mg/kg Vinflunine, although maximal overall inhibition is reached at the maximal tolerated dose (MTD) of 20 mg/kg [3]. 物理化学性质： CAS号：162652-95-1 常用中文名：长春氟宁 常用英文名：Vinflunine 分子式：C45H54F2N4O8 分子量：816.92900 密度：1.39 g/cm3 沸点：N/A 熔点：N/A 闪点：N/A 储存条件：-20°C，密闭，干燥 |
上海念兴实业有限公司
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- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：长春氟宁
- 价格：
- 纯度：98.0%
- 备货期：10天
- 联系人：徐经理
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：长春氟宁
- 价格： ￥2948.0/20mg
- 纯度：98.0%
- 备货期：2天
- 联系人：刘佳
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参考价格：$187/5mg