162652-95-1

• 常用中文名：长春氟宁
• 常用英文名：Vinflunine
• CAS号：162652-95-1
• 分子式：C₄₅H₅₄F₂N₄O₈
• 分子量：816.92900
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-03-04 08:00:00
• 更新时间：2026-06-30 12:55:08
• Vinflunine是新型氟化长春花生物碱,有阻断有丝分裂和微管蛋白相互作用的活性。

名称

• 中文名: 长春氟宁
• 英文名: Vinflunine
• 中文别名: 长春氟宁(治疗膀胱癌); 酒石酸长春氟宁
• 英文别名: Vinflunine Ttrate; 4'-Deoxy-20'; 20',20'-Difluoro-3',4'-dihydrovinorelbine; Vinflunine 162-1; 4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine; MFCD00938122; VINFLUNINE; Vinflunine (F12158); C'-Norvincaleukoblastine,4'-deoxy-20',20'-difluoro; 20',20'-difluoro-3',4'-dihydrovinorelbine; Aspidospermidine-3-cboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α); Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-15-[(12S,14R,16R)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraen-12-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate; vinflunine（）; methyl (2β,3β,4β,5α,12β,19α)-4-(acetyloxy)-15-[(4R,6R,8S)-4-(1,1-difluoroethyl)-8-(methoxycarbonyl)-1,3,4,5,6,7,8,9-octahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate; Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-15-[(12S,14R,16R)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraen-12-yl]-
 3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate; Aspidospermidine-3-cboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1; Vinflunine //BP; 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine; C45H54F2N4O8

物化性质

• 密度: 1.39 g/cm3
• 分子式: C₄₅H₅₄F₂N₄O₈
• 分子量: 816.92900
• 精确质量: 816.39100
• PSA: 133.87000
• LogP: 5.01950
• 折射率: 1.652
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Vinflunine是新型氟化长春花生物碱,有阻断有丝分裂和微管蛋白相互作用的活性。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  天然产物 >> 生物碱
  研究领域 >> 癌症
• 参考文献:

  [1]. Ngan, V.K., et al., Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. Cancer Res, 2000. 60(18): p. 5045-51.

  [2]. Lobert, S., et al., Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line. Biochemistry, 2000. 39(39): p. 12053-62.

  [3]. Kruczynski, A., et al., Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur J Cancer, 2006. 42(16): p. 2821-32.

合成路线

71486-22-1 ~34% 162652-95-1

文献：Fahy; Duflos; Ribet; Jacquesy; Berrier; Jouannetaud; Zunino Journal of the American Chemical Society, 1997 , vol. 119, # 36 p. 8576 - 8577

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