长春氟宁

• 常用名: 长春氟宁
• 英文名: Vinflunine
• CAS号: 162652-95-1
• 分子量: 816.92900
• 密度: 1.39 g/cm3
• 沸点: N/A
• 分子式: C₄₅H₅₄F₂N₄O₈
• 熔点: N/A
• 闪点: N/A

长春氟宁用途

Vinflunine是新型氟化长春花生物碱，有阻断有丝分裂和微管蛋白相互作用的活性。

长春氟宁名称

• 中文名: 长春氟宁
• 英文名: Vinflunine

长春氟宁生物活性

• 描述: Vinflunine是新型氟化长春花生物碱,有阻断有丝分裂和微管蛋白相互作用的活性。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  天然产物 >> 生物碱
  研究领域 >> 癌症
• 参考文献:

  [1]. Ngan, V.K., et al., Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. Cancer Res, 2000. 60(18): p. 5045-51.

  [2]. Lobert, S., et al., Vinca alkaloid-induced tubulin spiral formation correlates with cytotoxicity in the leukemic L1210 cell line. Biochemistry, 2000. 39(39): p. 12053-62.

  [3]. Kruczynski, A., et al., Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur J Cancer, 2006. 42(16): p. 2821-32.

长春氟宁物理化学性质

• 密度: 1.39 g/cm3
• 分子式: C₄₅H₅₄F₂N₄O₈
• 分子量: 816.92900
• 精确质量: 816.39100
• PSA: 133.87000
• LogP: 5.01950
• InChIKey: NMDYYWFGPIMTKO-ACNJXBQRSA-N
• SMILES: CCC12C=CCN3CCC4(c5cc(C6(C(=O)OC)CC7CC(C(C)(F)F)CN(Cc8c6[nH]c6ccccc86)C7)c(OC)cc5N(C)C4C(O)(C(=O)OC)C1OC(C)=O)C32
• 折射率: 1.652
• 储存条件: -20°C，密闭，干燥

长春氟宁靶点实验

查看更多实验

实验名称：Cytotoxicity against human SK-N-SH cells assessed as cell death at 50 uM after 72 hrs... 来源：ChEMBL 靶标：SK-N-SH External Id：CHEMBL2338874

实验名称：Cytotoxicity against human SK-N-SH cells assessed as cell death at 80 uM after 72 hrs... 来源：ChEMBL 靶标：SK-N-SH External Id：CHEMBL2338875

实验名称：Literature-mined compound from Fourches et al multi-species drug-induced liver injury... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1697778

实验名称：Literature-mined compound from Fourches et al multi-species drug-induced liver injury... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1697779

实验名称：Literature-mined compound from Fourches et al multi-species drug-induced liver injury... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1697780

实验名称：Blood clearance in Wistar rat at 0.3 mg/kg, iv 来源：ChEMBL 靶标：N/A External Id：CHEMBL5346638

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长春氟宁英文别名

• 4'-Deoxy-20'
• Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-15-[(12S,14R,16R)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraen-12-yl]-
 3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
• 4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine
• MFCD00938122
• C'-Norvincaleukoblastine,4'-deoxy-20',20'-difluoro
• 20',20'-difluoro-3',4'-dihydrovinorelbine
• Methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-15-[(12S,14R,16R)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0.0]octadeca-3(11),4,6,8-tetraen-12-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
• C45H54F2N4O8
• methyl (2β,3β,4β,5α,12β,19α)-4-(acetyloxy)-15-[(4R,6R,8S)-4-(1,1-difluoroethyl)-8-(methoxycarbonyl)-1,3,4,5,6,7,8,9-octahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate