苯并二氧六环-6-(1-哌啶基)甲酰胺
更新时间：2024-07-15 12:33:40
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| 常用名 | 苯并二氧六环-6-(1-哌啶基)甲酰胺 | CAS号 | 215923-54-9 |
|---|---|---|---|
| 价格 | 纯度 | 99.0% | |
| 备货期 | 10天 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.IC50 value:Target: AMPAR agonistin vitro: Treatments with the ampakine CX614 markedly and reversibly increased brain-derived neurotrophic factor (BDNF) mRNA and protein levels in cultured rat entorhinal/hippocampal slices [1]. in contrast to cyclothiazide or IDRA 21, the Ampakine CX546 binds specifically to the agonist bound nondesensitized receptor, most likely acting by destabilizing the desensitized receptor conformation [2]. In binding tests, CX546 caused an approximately 2-fold increase in the affinity for radiolabeled agonists, whereas CX516 was ineffective [3]. in vivo: Intraperitoneal injections of CX546 increased hippocampal BDNF mRNA levels in aged rats and middle-aged mice [1]. Administration of the positive modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPAR), CX546, during the conditioning phase only, improved the disrupted LI in mGluR5 knockout mice and facilitated LI in control C57BL/6J mice, given extended number of conditioning trails (four conditioning stimulus-unconditioned stimulus) [4]. 物理化学性质： CAS号：215923-54-9 常用中文名：苯并二氧六环-6-(1-哌啶基)甲酰胺 常用英文名：CX546 分子式：C14H17NO3 分子量：247.29000 密度：1.215g/cm3 沸点：422.8ºC at 760 mmHg 熔点：N/A 闪点：209.5ºC 储存条件：2-8℃ |
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- 产品名：CX 546
- 价格： ￥747.9/10mg ￥8239.9/250mg ￥2605.9/50mg ￥需询单/10g
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$117/10mM*1mLinDMSO