苯并二氧六环-6-(1-哌啶基)甲酰胺

• 常用名: 苯并二氧六环-6-(1-哌啶基)甲酰胺
• 英文名: CX546
• CAS号: 215923-54-9
• 分子量: 247.29000
• 密度: 1.215g/cm3
• 沸点: 422.8ºC at 760 mmHg
• 分子式: C₁₄H₁₇NO₃
• 熔点: N/A
• 闪点: 209.5ºC

苯并二氧六环-6-(1-哌啶基)甲酰胺用途

CX546是AMPAR受体选择性激动剂。

苯并二氧六环-6-(1-哌啶基)甲酰胺名称

• 中文名: 2-溴-1-(2,6-二氯苯基)乙酮
• 英文名: 2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone
• 中文别名: (2,3-二氢苯并[b][1,4]二噁英-6-基)(哌啶-1-基)甲酮 | 苯并二氧六环-6-(1-哌啶基)甲酰胺 | 1-(1,4-苯并二氧六环-6-基甲酰基)哌啶

苯并二氧六环-6-(1-哌啶基)甲酰胺生物活性

• 描述: CX546是AMPAR受体选择性激动剂。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Lauterborn JC, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci. 2000 Jan 1;20(1):8-21.

  [2]. Nagarajan N, et al. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Neuropharmacology. 2001 Nov;41(6):650-63.

  [3]. Arai AC, et al. Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J Pharmacol Exp Ther. 2002 Dec;303(3):1075-85.

  [4]. Lipina T, et al. The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. Neuropsychopharmacology. 2007 Apr;32(4):745-56.

苯并二氧六环-6-(1-哌啶基)甲酰胺物理化学性质

• 密度: 1.215g/cm3
• 沸点: 422.8ºC at 760 mmHg
• 分子式: C₁₄H₁₇NO₃
• 分子量: 247.29000
• 闪点: 209.5ºC
• 精确质量: 247.12100
• PSA: 38.77000
• LogP: 2.02180
• InChIKey: LJUNPHMOGNFFOS-UHFFFAOYSA-N
• SMILES: O=C(c1ccc2c(c1)OCCO2)N1CCCCC1
• 蒸汽压: 2.34E-07mmHg at 25°C
• 折射率: 1.573
• 储存条件: 2-8℃

苯并二氧六环-6-(1-哌啶基)甲酰胺安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

苯并二氧六环-6-(1-哌啶基)甲酰胺海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

苯并二氧六环-6-(1-哌啶基)甲酰胺靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：qHTS to identify inhibitors of the New Delhi Metallo-beta-lactamase (NDM): assay vali... 来源：NCGC External Id：adst_MBL_Abs_LOPAC_o1

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Human GluA2 (Ionotropic glutamate receptors) 来源：IUPHAR-DB 靶标：GluA2 (Ionotropic glutamate receptors) [Homo sapiens] External Id：445_Human

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：qHTS Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2... 来源：NCGC 靶标：ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] External Id：UBCH001

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

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苯并二氧六环-6-(1-哌啶基)甲酰胺英文别名

• CX 546
• Lopac-C-271
• BDP 17
• GR 87
• CX546