三氯氧磷

三氯氧磷用途

【用途一】
是制造有机磷农药杀虫脒的原料。用于生产磷酸二苯-异辛酯、磷酸三乙酯等磷酸酯及生产塑料增塑剂。用于长效磺胺药品的氯化反应。生产染料中间体、有机合成的氯化剂和催化剂，铀矿提取剂。
【用途二】
三氯氧磷俗名氧氯化磷，在有机磷农药合成中主要用于合成另一类含磷中间体——磷酰氯或磷酰二氯，如合成O，O-二乙基磷酰氯，进而合成农药乙基硫环磷，或合成O-乙基磷酰二氯，进而合成农药灭线磷等。在其他方面，三氯氧磷可作为氯化剂、催化剂、塑料增塑剂、染料中间体等，也用于制药工业和有机合成。
【用途三】
用作半导体掺杂剂，并为光导纤维原料。
【用途四】
广泛用于农药、医药、染料、磷酸酯及阻燃剂的生产，是制造有机磷农药除草剂、杀虫脒等的原料，用于生产塑料增塑剂。还用于长效磺胺药品的氯化反应，是生产染料的中间体，有机合成的氯化剂和催化剂、铀矿提取剂等。

三氯氧磷名称

[ CAS 号 ]:
10025-87-3

[ 中文名 ]:
三氯氧磷

[ 英文名 ]:
phosphoryl trichloride

[中文别名 ]:

磷酸氯

[英文别名 ]:

phosphorus trichloride oxide
fosforoxychloride
Phosphorus oxychloride
POCl3
Phosphorylchlorid
MFCD00011443
Fosforoxychlorid
Phosphorus oxychlori
Phosphoroxidchlorid
phosphonitrilic chloride trimer

三氯氧磷物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
105.3±9.0 °C at 760 mmHg

[ 熔点 ]:
1.25 °C(lit.)

[ 分子式 ]:
Cl₃OP

[ 分子量 ]:
153.332

[ 闪点 ]:
105.8°C

[ 精确质量 ]:
151.875229

[ PSA ]:
26.88000

[ LogP ]:
1.26

[ 外观性状 ]:
透明至淡黄色液体

[ 蒸汽密度 ]:
5.3 (vs air)

[ 蒸汽压 ]:
34.6±0.2 mmHg at 25°C

[ 折射率 ]:
1.453

[ 储存条件 ]:
库房通风低温干燥,与碱类分开存放

[ 稳定性 ]:
Stable. Reacts violently with water. Incompatible with many metals, alcohols, amines, phenol, DMSO, strong bases.

[ 水溶解性 ]:
reacts exothermically

三氯氧磷MSDS

详细MSDS(安全技术说明书)

三氯氧磷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH4897000

CHEMICAL NAME :: Phosphoryl chloride

CAS REGISTRY NUMBER :: 10025-87-3

LAST UPDATED :: 199806

DATA ITEMS CITED :: 25

MOLECULAR FORMULA :: Cl3-O-P

MOLECULAR WEIGHT :: 153.32

WISWESSER LINE NOTATION :: P O G3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534840

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,17,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534840

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 53 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - irritability Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 25,470,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1340 ug/m3/17W-I

REFERENCE :: JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology. (Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1- 1957- Volume(issue)/page/year: 21,387,1977 *** REVIEWS *** ACGIH TLV-TWA 0.63 mg/m3 (0.1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.6 mg/m3);STEL 0.5 ppm (3 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.1 ppm (0.63 mg/m3);STEL 0.5 ppm (3.1 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.6 mg/m3) JAN 1993 OEL-FINLAND:STEL 0.5 ppm (3 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.1 ppm (0.6 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.2 ppm (1 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.6 mg/m3) JAN 1993 OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.6 mg/m3);STEL 0.2 ppm (1.2 mg/m3) JAN 1993 OEL-TURKEY:TWA 0.5 ppm (3 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 ppm (1.2 mg/m3);STEL 0.6 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHOSPHORUS OXYCHLORIDE-air:10H TWA 0.1 ppm;STEL 0.5 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81931 No. of Facilities: 155 (estimated) No. of Industries: 7 No. of Occupations: 22 No. of Employees: 7258 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81931 No. of Facilities: 165 (estimated) No. of Industries: 9 No. of Occupations: 29 No. of Employees: 12587 (estimated) No. of Female Employees: 2945 (estimated)

三氯氧磷安全信息

[ 符号 ]:

GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H330-H314-H372

[ 补充危害声明 ]:
Contact with water liberates toxic gas., Reacts violently with water.

[ 警示性声明 ]:
P260-P280-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P403 + P233

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R14;R22;R26;R35;R48/23

[ 安全声明 (欧洲) ]:
S26-S45-S7/8-S36/37/39

[ 危险品运输编码 ]:
UN 1810 8/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
TH4897000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2812102000

三氯氧磷合成路线

详细合成路线

三氯氧磷上下游产品

三氯氧磷上游产品

三氯氧磷下游产品

三氯氧磷制备

1.以三氯化磷为原料进行氧化，若采用不同的氧化剂则有多种不同的制备方法。工业上主要采用氯化水解法，即将三氯化磷加入反应器中，通入氯气，同时滴加水，控制一定的氯水比和通氯、滴水速度，用夹套蒸汽加热至105～109℃，使反应器内反应物气化，经冷凝器冷凝后再回流入反应器中。二次通入氯气，继续氯化残存的三氯化磷。回流至反应物色泽洁白、三氯化磷残存量在0.2％以下时，可由冷凝器导出作为三氯氧磷成品。

反应生成的氯化氢气体经水吸收生成稀盐酸。此外，也可通过将干燥的氧气通入三氯化磷，或由五氧化二磷与五氯化磷作用，或用氯气和二氧化硫作氧化剂等方法得到三氯氧磷。

2.在一只装有回流冷凝器的250mL三颈圆底烧瓶中放入100g PCl3，然后一份份(每份不大于0.5～1g的剂量)地加入33g磨细的KClO3，并且在前一份KClO3加入后所引起的剧烈反应停止后，才能加另一份。反应结束后(当最后几份不起作用时)，取下冷凝管，改成蒸馏装置进行蒸馏，收集105～108℃间的馏分。

3.以试剂级三氯氧磷为原料，加入石英蒸馏设备中进行精馏精制，制得高纯三氯氧磷成品。

4.在装有三氯化磷的反应器中同时通入氯气和加入水，并控制Cl2:H2O ＝3.94∶ 1，通氯气速度为25～35kg/h，加水速度为 6.25～8.8kg/h，反应如下：

用蒸汽加热至105～109℃，汽化后全部冷凝流回反应器，第二次通入氯气，加热回流至三氯化磷含量小于2%，收集105～109℃馏分，即为三氯氧磷。

三氯氧磷海关

[ 海关编码 ]: 2812102000

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