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盐酸阿齐利特

盐酸阿齐利特用途

Azimilide二盐酸盐(NE-10064)是抗心律失常化合物，能抑制I(Ks)和I(Kr)活性。

盐酸阿齐利特名称

[ CAS 号 ]:
149888-94-8

[ 中文名 ]:
盐酸阿齐利特

[ 英文名 ]:
Azimilide (Dihydrochloride)

[英文别名 ]:

azmilide
Azimilide hydrochloride
Stedicor
Azimilide HCl
Azimilide dihydrochloride
Azimilide (Dihydrochloride)

盐酸阿齐利特生物活性

[ 描述 ]:

Azimilide二盐酸盐(NE-10064)是抗心律失常化合物,能抑制I(Ks)和I(Kr)活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钾通道

研究领域 >> 心血管疾病

[参考文献]

[1]. Busch AE, et al. Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action. Br J Pharmacol. 1998 Jan;123(1):23-30.

[2]. Yao JA, et al. Azimilide (NE-10064) can prolong or shorten the action potential duration in canine ventricular myocytes: dependence on blockade of K, Ca, and Na channels. J Cardiovasc Electrophysiol. 1997 Feb;8(2):184-98.

[3]. Fermini B, et al. Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: block of delayed rectifier potassium and L-type calcium currents. J Cardiovasc Pharmacol. 1995 Aug;26(2):259-71.

[4]. Black SC, et al. Protection against programmed electrical stimulation-induced ventricular tachycardia and sudden cardiac death by NE-10064, a class III antiarrhythmic drug. J Cardiovasc Pharmacol. 1993 Dec;22(6):810-8.

[相关活性小分子]

盐酸阿齐利特物理化学性质

[ 密度 ]:
1.32g/cm3

[ 沸点 ]:
594.9ºC at 760mmHg

[ 分子式 ]:
C₂₃H₃₀Cl₃N₅O₃

[ 分子量 ]:
530.87500

[ 闪点 ]:
313.6ºC

[ 精确质量 ]:
529.14100

[ PSA ]:
72.60000

[ LogP ]:
4.58130

[ 储存条件 ]:
2-8℃

盐酸阿齐利特MSDS

详细MSDS(安全技术说明书)

盐酸阿齐利特安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

盐酸阿齐利特文献

Azimilide dihydrochloride: a new class III anti-arrhythmic agent.

Expert Opin. Investig. Drugs 9(11) , 2705-15, (2000)

Azimilide dihydrochloride (Stedicor) is a new class III anti-arrhythmic agent that is being developed by Proctor & Gamble to treat supraventricular and ventricular arrhythmias. Development of this age...

Electrophysiological and antiarrhythmic effects of the novel antiarrhythmic agent AZD7009: a comparison with azimilide and AVE0118 in the acutely dilated right atrium of the rabbit in vitro.

Europace 8(7) , 549-57, (2006)

To compare the electrophysiological and antiarrhythmic effects of AZD7009, azimilide, and AVE0118 in the acutely dilated rabbit atria in vitro.In the isolated Langendorf-perfused rabbit heart, the atr...

Azimilide for the treatment of atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia: results of a randomized trial and insights on the concordance of symptoms and recurrent arrhythmias.

J. Cardiovasc. Electrophysiol. 19(2) , 172-7, (2008)

Azimilide hydrochloride is an investigational antiarrhythmic medication that had shown evidence of efficacy in prolonging the time to recurrence of atrial fibrillation (AF) or atrial flutter (AFL) and...

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