7,4'-二羟基黄酮

7,4'-二羟基黄酮用途

7,4'-Dihydroxyflavone (7,4'-DHF) 7,4'-二羟基黄酮是从甘草 Glycyrrhiza uralensis 中分离的类黄酮,eotaxin/CCL11 抑制剂,抑制嗜酸性粒细胞趋化因子产生。7,4'-Dihydroxyflavone 通过调节 NF-κB,STAT6 和 HDAC2 抑制 MUC5A 基因表达和粘液产生。7,4'-Dihydroxyflavone 降低 (PMA) 刺激的 NCI-H292 细胞 MUC5AC 表达,IC50 值为 1.4 μM。

7,4'-二羟基黄酮名称

[ CAS 号 ]:
2196-14-7

[ 中文名 ]:
7,4’-二羟基黄酮

[ 英文名 ]:
4',7-Dihydroxyflavone

[中文别名 ]:

[英文别名 ]:

7,4'-Dihydroxyflavanone
7,4'-Dihydroxyflavone
FLAVONE,4',7-DIHYDROXY
7-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
4',7-Dihydroxyflavone

7,4'-二羟基黄酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> CCR

信号通路 >> 免疫及炎症 >> CCR

研究领域 >> 炎症/免疫

[ 靶点 ]

IC50: 1.4 μM (NCI-H292 human airway epithelial cell) (7,4'-Dihydroxyflavone)[2]

[参考文献]

[1]. Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts. Phytother Res. 2017 Mar;31(3):449-458.

[2]. Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2. Phytother Res. 2015 Jun;29(6):925-32.

7,4'-二羟基黄酮物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
512.8±50.0 °C at 760 mmHg

[ 熔点 ]:
324-325ºC

[ 分子式 ]:
C₁₅H₁₀O₄

[ 分子量 ]:
254.238

[ 闪点 ]:
201.2±23.6 °C

[ 精确质量 ]:
254.057907

[ PSA ]:
70.67000

[ LogP ]:
2.54

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.699

[ 储存条件 ]:
2-8℃，干燥，密闭

7,4'-二羟基黄酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK8329000

CHEMICAL NAME :: Flavone, 4',7-dihydroxy-

CAS REGISTRY NUMBER :: 2196-14-7

BEILSTEIN REFERENCE NO. :: 0224356

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H10-O4

MOLECULAR WEIGHT :: 254.25

WISWESSER LINE NOTATION :: T66 BO EVJ CR DQ& IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981

7,4'-二羟基黄酮安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2914501900

7,4'-二羟基黄酮合成路线

详细合成路线

7,4'-二羟基黄酮海关

[ 海关编码 ]: 2914501900

[ 中文概述 ]:
2914501900 其他酮酚。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%