异氰尿酸三缩水甘油酯

异氰尿酸三缩水甘油酯用途

Triglycidyl isocyanurate (TGIC; Teroxirone) 是一种具有抗血管生成和抗肿瘤活性的三氮烯三环氧化合物。Triglycidyl isocyanurate 通过 p53 的激活抑制非小细胞肺癌细胞的生长。Triglycidyl isocyanurate 诱导细胞凋亡 (apoptosis)。Triglycidyl isocyanurate 可用于癌症研究。

异氰尿酸三缩水甘油酯名称

[ CAS 号 ]:
2451-62-9

[ 中文名 ]:
1,3,5-三缩水甘油-S-三嗪三酮

[ 英文名 ]:
Triglycidyl isocyanurate

[中文别名 ]:

[英文别名 ]:

XB 2615
tgt
Teroxirone
EINECS 219-514-3
TGIC
Isocyanuric Acid Triglycidyl Ester
T6NVNVNVJ A1- BT3OTJ& C1- BT3OTJ& E1- BT3OTJ
1,3,5-triglycidyl-s-triazinetrione
MFCD00080670
araldite pt-810

异氰尿酸三缩水甘油酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞凋亡 >> MDM-2/p53

研究领域 >> 炎症/免疫

[体外研究]

异氰脲酸三缩水甘油酯(0-30μM；48 小时)降低培养的人非小细胞肺癌细胞球体的生长,导致A549、H460和H1299细胞的肿瘤球逐渐缩小[1]。异氰尿酸三缩水甘油酯(0-30μM；48 小时)抑制A549、H460和H1299肿瘤球的akt1/2/3和磷酸化Aktser473/474/472的表达,然而,只有在H460和A549肿瘤球中才能看到PARP和procaspase-3的断裂以及涌现的活性caspase-3片段[1]。细胞活力测定[1]细胞株：A549、H460、H1299细胞浓度：0μM；5μM；10μM；30μM孵育时间：48h。结果：软琼脂培养抑制肿瘤细胞生长。Western Blot分析[1]A549、H460和H1299细胞浓度：0μM；5μM；10μM；30μM孵育时间：48h。结果：抑制A549、H460和H1299肿瘤球中akt1/2/3和p-aktser473/474/472的表达

[体内研究]

异氰尿酸三缩水甘油酯(皮下注射；1.8和3.6 mg/kg；每2-3天注射一次,共7次；30天)抑制异种移植瘤的生长,对裸鼠体重无影响[2]。动物模型：雌性nu/nu小鼠背部皮下注射Huh7细胞[2]剂量：1.8mg/kg和3.6mg/kg给药：皮下注射,每2-3天共7次；30天结果：抑制异种移植瘤的生长。

[参考文献]

[1]. Yu-Ling Ni, et al. Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells. Chem Biol Interact. 2018 Aug 1;291:137-143

[2]. Seung-Hun Kim, et al. Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.Biomed Pharmacother. 2018 Mar;99:997-1008

异氰尿酸三缩水甘油酯物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
501.1±15.0 °C at 760 mmHg

[ 熔点 ]:
95-98°C

[ 分子式 ]:
C₁₂H₁₅N₃O₆

[ 分子量 ]:
297.264

[ 闪点 ]:
256.9±20.4 °C

[ 精确质量 ]:
297.096100

[ PSA ]:
103.59000

[ LogP ]:
-2.77

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.635

[ 储存条件 ]:
室温

[ 水溶解性 ]:
<0.1 g/100 mL at 20 ºC

异氰尿酸三缩水甘油酯MSDS

详细MSDS(安全技术说明书)

异氰尿酸三缩水甘油酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ1994900

CHEMICAL NAME :: s-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2,3-epoxypropyl)-

CAS REGISTRY NUMBER :: 2451-62-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C12-H15-N3-O6

MOLECULAR WEIGHT :: 297.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1200 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,175,1990 *** REVIEWS *** ACGIH TLV-TWA 0.05 mg/m3 85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986 Volume(issue)/page/year: 6,1/BEI,1997

异氰尿酸三缩水甘油酯安全信息

[ 符号 ]:

GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H331-H317-H318-H340-H373-H412

[ 警示性声明 ]:
P201-P261-P273-P280-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R23/25;R41;R43;R48/22;R52/53

[ 安全声明 (欧洲) ]:
S53-S45-S61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
XZ1994900

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933699090

异氰尿酸三缩水甘油酯上下游产品

异氰尿酸三缩水甘油酯上游产品

异氰尿酸三缩水甘油酯下游产品

异氰尿酸三缩水甘油酯制备

（１）三聚氰酸与环氧氯丙烷在碱作用下制得。
（２）三聚氰酰氯（或溴）和环氧丙醇在惰性溶剂中，以无机碱或叔胺催化，经醇解制得。

异氰尿酸三缩水甘油酯海关

[ 海关编码 ]: 2933699090

[ 中文概述 ]:
2933699090 其他结构上含非稠合三嗪环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

异氰尿酸三缩水甘油酯文献

Determination of triglycidyl isocyanurate from air samples by ultra-performance liquid chromatography coupled with coordination ion spray mass spectrometry.

Rapid Commun. Mass Spectrom. 29 , 913-8, (2015)

Ultra-performance liquid chromatography (UPLC) coupled with coordination ion spray tandem mass spectrometry was used for the analysis of air samples containing triglycidyl isocyanurate. The method is ...

Pharmacological characterization of teroxirone, a triepoxide antitumor agent, in rats, rabbits, and humans.

Cancer Res. 44(9) , 4151-6, (1984)

Teroxirone is an experimental triepoxide antitumor agent currently undergoing evaluation in clinical trials. We have developed an assay based on derivatization with diethyldithiocarbamate followed by ...

Occupational contact dermatitis from triglycidyl isocyanurate in a powder paint factory.

Contact Dermatitis 26(1) , 59, (1992)

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