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原烟碱

原烟碱用途

(S)-Nornicotine 是尼古丁的代谢物。

原烟碱名称

[ CAS 号 ]:
494-97-3

[ 中文名 ]:
原烟碱

[ 英文名 ]:
(S)-Nornicotine

[中文别名 ]:

[英文别名 ]:

(S)-3-(Pyrrolidin-2-yl)pyridine
3-(2-Pyrrolidinyl)pyridine
3-(2S)-2-pyrrolidinylpyridine
(S)-Nornicotine
3-[(2S)-pyrrolidin-2-yl]pyridine

原烟碱生物活性

[ 描述 ]:

(S)-Nornicotine 是尼古丁的代谢物。

[ 相关类别 ]:

天然产物 >> 生物碱

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

原烟碱物理化学性质

[ 密度 ]:
1.043g/cm3

[ 沸点 ]:
269.999ºC at 760 mmHg

[ 分子式 ]:
C₉H₁₂N₂

[ 分子量 ]:
148.20500

[ 闪点 ]:
111.291ºC

[ 精确质量 ]:
148.10000

[ PSA ]:
24.92000

[ LogP ]:
1.83490

[ 蒸汽压 ]:
0.007mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

原烟碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QS6405000

CHEMICAL NAME :: Nicotine, 1'-demethyl-, (S)-

CAS REGISTRY NUMBER :: 494-97-3

BEILSTEIN REFERENCE NO. :: 0081968

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H12-N2

MOLECULAR WEIGHT :: 148.23

WISWESSER LINE NOTATION :: T6NJ C- BT5MTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14660 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3409 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >13700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 2500 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,281,1983

原烟碱安全信息

[ 海关编码 ]:
2933990090

原烟碱合成路线

详细合成路线

原烟碱上下游产品

原烟碱上游产品

原烟碱下游产品

原烟碱海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

原烟碱