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N-乙酰半胱氨酸

N-乙酰半胱氨酸用途

Acetylcysteine是一种粘液溶解剂,可以减少粘液的厚度。
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N-乙酰半胱氨酸名称

[ CAS 号 ]:
616-91-1

[ 中文名 ]:
N-乙酰-L-半胱氨酸

[ 英文名 ]:
Acetylcysteine(N-acetylcysteine)

[中文别名 ]:

[英文别名 ]:

N-乙酰半胱氨酸生物活性

[ 描述 ]:

Acetylcysteine是一种粘液溶解剂,可以减少粘液的厚度。

[ 相关类别 ]:

研究领域 >> 神经疾病
天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite


[体外研究]

在血清剥夺的PC12细胞中,N-乙酰半胱氨酸可以防止细胞凋亡的DNA片段化,并在没有其他营养支持的情况下维持长期存活。 N-乙酰半胱氨酸还可以预防PC12细胞和交感神经元的死亡[2]。 N-乙酰半胱氨酸导致大鼠和人主动脉平滑肌细胞活力的剂量依赖性降低[3]。 N-乙酰半胱氨酸激活PC12细胞中的Ras-细胞外信号调节激酶(ERK)途径。 N-乙酰半胱氨酸保护神经元细胞免于因营养支持的撤除而引起的死亡。 N-乙酰半胱氨酸增加血管组织中蛋白质结合储存的一氧化氮(NO)释放。 PC12细胞的N-乙酰半胱氨酸预处理干扰NGF依赖性信号传导和神经突向外生长,并且提示N-乙酰半胱氨酸干扰NGF机制中的氧化还原敏感步骤[4]。

[体内研究]

在所有治疗组中,N-乙酰半胱氨酸(150,300 mg/kg)治疗显着降低肝转氨酶,主要是在N-乙酰半胱氨酸组300中。肺组织中谷胱甘肽过氧化物酶在N-乙酰半胱氨酸组300中显着增加(P = 0.04),而其他氧化生物标志物没有显着差异[1]。 N-乙酰半胱氨酸可改善12个月大的SAMP8小鼠在T迷宫足部避免范例和杠杆按压食欲任务中的认知,而不会对运动活动,避免休克的动机或体重产生非特异性影响[5]。

[细胞实验]

对于存活实验,将洗涤的细胞重悬于RPM11640培养基中,并在涂有鼠尾胶原的24孔塑料培养皿中以每孔8-10×105的密度接种0.5mL。为了喂养,但为了避免漂浮细胞的损失,在第1,5和10天向培养物中加入新鲜培养基(0.2mL)。对于涉及“引发的”PC12细胞的实验,用NGF预处理培养物1-2周。在RPM1 1640培养基中补充1%热-iN-乙酰半胱氨酸化的马血清。然后洗涤细胞并传代到无血清的RPM11640培养基中。

[动物实验]

大鼠:大鼠随机分为5组:假手术组(n = 5),对照组IIR(n = 8)和3组IIR给予不同剂量的N-乙酰半胱氨酸:150 mg / kg腹腔注射5 min缺血(n = 8,N-乙酰半胱氨酸组150),缺血前5分钟腹腔注射300 mg / kg(n = 7,N-乙酰半胱氨酸组300),缺血前5分钟腹腔注射150 mg / kg加150 mg / kg 5再灌注前min(n = 7,N-乙酰半胱氨酸组150 + 150)。再灌注4小时后,通过腹主动脉放血使动物安乐死。

[参考文献]

[1]. Kalimeris K, et al. N-acetylcysteine ameliorates liver injury in a rat model of intestinal ischemia reperfusion. J Surg Res. 2016 Dec;206(2):263-272

[2]. Ferrari G, et al. N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci. 1995 Apr;15(4):2857-66.

[3]. Tsai JC, et al. Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem. 1996 Feb 16;271(7):3667-70.

[4]. Yan CY, et al. Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J Neurosci. 1998 Jun 1;18(11):4042-9.

[5]. Farr SA, et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem. 2003 Mar;84(5):1173-83.


[相关活性小分子]

3-甲基腺嘌呤 | 氢化可的松 | 维生素A酸; 视黄酸 | 褪黑素 | 地诺前列酮 | 烟酰胺 | 5'-三磷酸腺苷 | 对乙酰氨基苯酚 | 列腺素 E1 | 去氢表雄酮 | 肾上腺酮 | 孕酮; 黄体素; 黄体酮 | 二十二碳六烯酸 | 辅酶I | P物质

N-乙酰半胱氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
407.7±40.0 °C at 760 mmHg

[ 熔点 ]:
106-108 °C(lit.)

[ 分子式 ]:
C5H9NO3S

[ 分子量 ]:
163.195

[ 闪点 ]:
200.4±27.3 °C

[ 精确质量 ]:
163.030319

[ PSA ]:
105.20000

[ LogP ]:
-0.15

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±2.0 mmHg at 25°C

[ 折射率 ]:
1.519

[ 储存条件 ]:
库房通风低温干燥,与酸类、碱类、氧化剂、食品添加剂分开存放

[ 水溶解性 ]:
水溶性:可溶;可溶于:醇

N-乙酰半胱氨酸MSDS

N-乙酰半胱氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA1660000
CHEMICAL NAME :
Cysteine, N-acetyl-, L-
CAS REGISTRY NUMBER :
616-91-1
LAST UPDATED :
199701
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C5-H9-N-O3-S
MOLECULAR WEIGHT :
163.21
WISWESSER LINE NOTATION :
SH1YVQMV1 -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Multiple routes
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
8480 mg/kg/3D-I
TOXIC EFFECTS :
Liver - liver function tests impaired
REFERENCE :
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 79,281,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5050 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1140 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
EJRDD2 European Journal of Respiratory Diseases. (Munksgaard International Pub., c/o Pub. Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.61- 1980- Volume(issue)/page/year: 61(Suppl 111),45,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0192191
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3800 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,1172,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,479,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,479,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,479,1979 *** REVIEWS *** TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 12,601,1978 TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,479,1979 TOXICOLOGY REVIEW EJRDD2 European Journal of Respiratory Diseases. (Munksgaard International Pub., c/o Pub. Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.61- 1980- Volume(issue)/page/year: 61(Suppl 111),45,1980 TOXICOLOGY REVIEW PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977- Volume(issue)/page/year: 2,479,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81688 No. of Facilities: 616 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 4525 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81688 No. of Facilities: 1677 (estimated) No. of Industries: 1 No. of Occupations: 14 No. of Employees: 31203 (estimated) No. of Female Employees: 21201 (estimated)
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N-乙酰半胱氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
HA1660000

[ 海关编码 ]:
2930909090

N-乙酰半胱氨酸合成路线

N-乙酰半胱氨酸上下游产品

N-乙酰半胱氨酸制备

合成方法: 1.将左旋半胱氨酸盐酸盐(无结晶水)溶于0.8倍蒸馏水,此时可适当加热。然后在加有活性炭的漏斗中过滤,滤液加入3.6倍体积的95%药用乙醇,再加入工业吡啶(0.8倍体积)先在冰水浴中冷却后,再放入冰箱过夜,次日过滤,用三氯甲烷(工业品)洗涤,过滤,压干,迅速放入真空干燥器,常温干燥5h,得左旋半胱氨酸。收率86.5%。

以L-半胱氨酸与醋酐乙酰化即得

中和 将无结晶水的L-半胱氨酸盐酸盐溶于0.8倍的蒸馏水中,经水浴微热溶解后倒人预先铺有活性炭的布氏漏斗中抽滤,取滤液并加入乙醇 (95%),再加入吡啶搅拌后,放人冰水浴中冷却,再置人冰箱中过夜,析出结晶,过滤取结晶,用CHCl3洗涤,压干。迅速放人真空干燥器中干燥,得L-半胱氨酸。
乙酰化 将L-半胱氨酸投入反应罐中,加入冰醋酸、三氯甲烷,在剧烈搅拌下加入醋酐。反应罐夹层加热至35℃左右后,停止加热,罐内温度逐渐上升至82-85℃,为控制温度过高,在70℃左右时开始冷却,维持50℃左右搅拌半小时后,过滤取滤液,并减压浓缩,当比较黏稠时,再加适量水浓缩。如此反复几次,当浓缩液为半胱氨酸1.8倍左右时,冷却并加入少许L-半胱氨酸晶体接种,放入冰箱中过夜、结晶,过滤取结晶压干,用乙醚洗涤,得乙酰半胱氨酸粗品。
精制 粗品放入0.5-0.6倍的蒸馏水中溶解,加5%活性炭脱色,过滤取滤液,放人冰箱中过夜,析出结晶,过滤取结晶,压干,用乙醚洗涤,真空干燥,得乙酰半胱氨酸精品。

2.

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N-乙酰半胱氨酸海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-乙酰半胱氨酸文献

Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage.

Leuk. Lymphoma 56(3) , 739-47, (2015)

The tumor suppressor p53 is often mutated in human cancers. Restoring its antitumor activity has been shown to be a promising therapeutic approach for cancer treatment. Here we analyzed the activity a...

Mitochondrial dynamics regulate melanogenesis through proteasomal degradation of MITF via ROS-ERK activation.

Pigment Cell Melanoma Res. 27(6) , 1051-62, (2014)

Mitochondrial dynamics control mitochondrial functions as well as their morphology. However, the role of mitochondrial dynamics in melanogenesis is largely unknown. Here, we show that mitochondrial dy...

Antiviral effect of methylated flavonol isorhamnetin against influenza.

PLoS ONE 10(3) , e0121610, (2015)

Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, and animals. Influenza is a serious economic conc...


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联系人:刘佳

产品详情:N-乙酰-L-半胱氨酸


公司名:南京肽业生物科技有限公司

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价格:
¥需询单/10g ¥需询单/100g ¥需询单/1kg ¥需询单/10kg

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产品详情:Ac-Cys-OH


公司名:上海脉铂医药科技有限公司

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¥589.0/1g ¥589.0/10g ¥489.0/5g ¥需询单/1g

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产品详情:Acetylcysteine


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¥47.0/25g ¥108.0/100g ¥394.0/500g ¥1574.0/2500g

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产品详情:[Perfemiker]|N|-乙酰-L-半胱氨酸,99%


公司名:上海阿拉丁生化科技股份有限公司

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¥107.9/100g ¥29.9/10g ¥42.9/25g ¥409.9/500g

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N-乙酰半胱氨酸相关知识

[乙酰半胱氨酸] - 说明书 - 作用 - 乙酰半胱氨酸颗粒副作用

2018-12-17 17:11:30

导读:乙酰半胱氨酸(Acetylcysteine),又称为N-乙酰半胱氨酸(N-acetylcysteine)或N-乙酰-L-半胱氨酸(N-acetyl-L-cysteine),常简称做NAC。本品可用于治疗对乙酰氨基酚(普拿疼)中毒,且可用于解化过浓的黏液,因此可用于缓解囊肿性纤维化及慢性阻塞性...


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【N-乙酰半胱氨酸】化源网提供N-乙酰半胱氨酸CAS号616-91-1,N-乙酰半胱氨酸MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询N-乙酰半胱氨酸上化源网,专业又轻松。>>电脑版:N-乙酰半胱氨酸

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