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肾上腺酮

肾上腺酮用途

Corticosterone是一种肾上腺皮质类固醇,作为盐皮质激素和糖皮质激素具有适度但显着的活性。
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肾上腺酮名称

[ CAS 号 ]:
50-22-6

[ 中文名 ]:
皮质甾酮

[ 英文名 ]:
Corticosterone

[中文别名 ]:

[英文别名 ]:

肾上腺酮生物活性

[ 描述 ]:

Corticosterone是一种肾上腺皮质类固醇,作为盐皮质激素和糖皮质激素具有适度但显着的活性。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
研究领域 >> 神经疾病
天然产物 >> 类固醇

[ 靶点 ]

Human Endogenous Metabolite


[参考文献]

[1]. Gasser PJ, et al. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organiccation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci. 2006 Aug 23;26(34):8758-8766.


[相关活性小分子]

3-甲基腺嘌呤 | 氢化可的松 | N-乙酰半胱氨酸 | 维生素A酸； 视黄酸 | 褪黑素 | 地诺前列酮 | 米非司酮 | 烟酰胺 | 5'-三磷酸腺苷 | 对乙酰氨基苯酚 | 列腺素 E1 | 去氢表雄酮 | 孕酮； 黄体素； 黄体酮 | 二十二碳六烯酸 | 辅酶I

肾上腺酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
529.2±50.0 °C at 760 mmHg

[ 熔点 ]:
179-183 °C(lit.)

[ 分子式 ]:
C21H30O4

[ 分子量 ]:
346.461

[ 闪点 ]:
288.0±26.6 °C

[ 精确质量 ]:
346.214417

[ PSA ]:
74.60000

[ LogP ]:
1.76

[ 外观性状 ]:
白色至淡黄色粉末

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.576

[ 储存条件 ]:
Store at RT

[ 稳定性 ]:
Stable, but light sensitive. Incompatible with strong oxidizing agents.

肾上腺酮MSDS

详细MSDS(安全技术说明书)

肾上腺酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GM7650000
CHEMICAL NAME :
Corticosterone
CAS REGISTRY NUMBER :
50-22-6
BEILSTEIN REFERENCE NO. :
2339601
LAST UPDATED :
199703
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C21-H30-O4
MOLECULAR WEIGHT :
346.51
WISWESSER LINE NOTATION :
L E5 B666 OV MUTJ A1 CQ E1 FV1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
14 mg/kg
SEX/DURATION :
female 19-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
525 mg/kg
SEX/DURATION :
female 12-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - endocrine system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
500 mg/kg
SEX/DURATION :
female 8-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
84 mg/kg
SEX/DURATION :
female 16-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1472 mg/kg
SEX/DURATION :
female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
400 mg/kg
SEX/DURATION :
female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
100 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
400 mg/kg
SEX/DURATION :
female 11-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
40 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
80 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Bird - chicken Embryo
DOSE/DURATION :
1500 pmol/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 257,804,1975
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肾上腺酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi,N,Xn,T

[ 风险声明 (欧洲) ]:
R43

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
2811.0

[ WGK德国 ]:
3

[ RTECS号 ]:
GM7650000

[ 危险类别 ]:
6.1

肾上腺酮合成路线

详细合成路线

肾上腺酮上下游产品

肾上腺酮上游产品

肾上腺酮下游产品

肾上腺酮制备

可由肾上腺提取液分离，也可由胆汁酸、山药皂草苷等制得。
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肾上腺酮文献

Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.

Br. J. Pharmacol. 172(3) , 857-68, (2015)

AT1 receptor blockers (ARBs) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight and onset of type 2 diabetes. The mechanism underlying ARB...

Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice.

PLoS ONE 9(5) , e98398, (2014)

Osteopontin (OPN) is a multifunctional extracellular matrix (ECM) protein involved in multiple physiological processes. OPN expression is dramatically increased in visceral adipose tissue in obesity a...

Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia.

J. Appl. Physiol. 117(7) , 765-76, (2014)

Obstructive sleep apnea causes chronic intermittent hypoxia (IH) and is associated with impaired glucose metabolism, but mechanisms are unknown. Carotid bodies orchestrate physiological responses to h...


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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

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联系人：徐经理

产品详情：肾上腺酮

公司名：上海吉至生化科技有限公司

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价格：
￥198.0/20mg ￥88.0/100mg ￥278.0/500mg

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区域：上海市浦东新区

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￥需询单/1g

联系人：赖经理

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区域：上海市嘉定区

价格：
￥489.0/1g ￥519.0/50mg ￥需询单/1g ￥需询单/1g

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产品详情：Corticosterone

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥185.9/100mg ￥460.9/1g ￥288.9/500mg ￥308.9/1ml

联系人：阿拉丁

产品详情：皮质甾酮

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【肾上腺酮】化源网提供肾上腺酮CAS号50-22-6，肾上腺酮MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询肾上腺酮上化源网，专业又轻松。>>电脑版：肾上腺酮

标题：肾上腺酮_MSDS_用途_密度_肾上腺酮CAS号【50-22-6】_化源网 地址：https://m.chemsrc.com/mip/cas/50-22-6_831493.html