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L-羟脯氨酸

L-羟脯氨酸用途

L-Hydroxyproline 是羟脯氨酸 (Hyp) 的异构体之一,是许多药物生产中有用的手性结构单元。

L-羟脯氨酸名称

[ CAS 号 ]:
51-35-4

[ 中文名 ]:
L-羟基脯氨酸

[ 英文名 ]:
L-Hydroxyproline

[中文别名 ]:

[英文别名 ]:

4-Hydroxyproline
(2S,4R)-4-hydroxypyrrolidinium-2-carboxylate
Hydroxyproline
MFCD00064320
L-Hydroxyproline
trans-Lachnophyllol
trans-4-hydroxyproline
Proline, 4-hydroxy-, L-
trans-L-4-hydroxyproline
(2S,4R)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid

L-羟脯氨酸生物活性

[ 描述 ]:

L-Hydroxyproline 是羟脯氨酸 (Hyp) 的异构体之一,是许多药物生产中有用的手性结构单元。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

L-羟脯氨酸(Trans-4-hydroxy-L-proline; Trans-Hyp)已广泛应用于医药,生物化学,食品,化妆品等行业。另外,还在一些次级代谢物如放线菌素和棘白菌素的组合物中发现了L-羟脯氨酸。 L-羟脯氨酸在工业上大多数是通过哺乳动物胶原的酸水解制造的,因为它在胶原中含量丰富[1]。

[参考文献]

[1]. Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44.

[相关活性小分子]

L-羟脯氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
355.2±42.0 °C at 760 mmHg

[ 熔点 ]:
273 °C (dec.)(lit.)

[ 分子式 ]:
C₅H₉NO₃

[ 分子量 ]:
131.130

[ 闪点 ]:
168.6±27.9 °C

[ 精确质量 ]:
131.058243

[ PSA ]:
69.56000

[ LogP ]:
-1.84

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.540

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
357.8 g/L (20 º C)

L-羟脯氨酸MSDS

L-羟脯氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TW3586500

CHEMICAL NAME :: Proline, 4-hydroxy-, L-

CAS REGISTRY NUMBER :: 51-35-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996

L-羟脯氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TW3586500

[ 海关编码 ]:
2933990090

L-羟脯氨酸合成路线

L-羟脯氨酸上下游产品

L-羟脯氨酸上游产品

L-羟脯氨酸下游产品

L-羟脯氨酸制备

【方法一】
由明胶、骨胶、干酪素、大豆表皮等蛋白质，用盐酸水解，用亚硝化法提取亚氨酸后经树脂层析后精制、结晶而成。得率约7.0%。

L-羟脯氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

L-羟脯氨酸文献

Ameliorative effect of mepenzolate bromide against pulmonary fibrosis.

J. Pharmacol. Exp. Ther. 350(1) , 79-88, (2014)

Idiopathic pulmonary fibrosis is thought to involve lung injury caused by reactive oxygen species (ROS), which in turn is followed by abnormal fibrosis. A transforming growth factor (TGF)-β1-induced i...

[Effect of cordyceps polysaccharide on lipid peroxidation of rats with dimethylnitrosamine-induced liver fibrosis].

Zhongguo Zhong Yao Za Zhi 38(3) , 391-6, (2013)

To observe the pharmacological effect of Cordyceps polysaccharide on dimethylnitrosamine (DMN)-induced liver fibrosis in rats.DMN rat liver fibrosis model was established and divided into the normal g...

Use of Commercial Dry Yeast Products Rich in Mannoproteins for White and Rosé Sparkling Wine Elaboration.

J. Agric. Food Chem. 63 , 5670-81, (2015)

In sparkling wines, mannoproteins released during yeast autolysis largely affect their final quality. This process is very slow and may take several months. The aim of this work was to study the effec...

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