<生产厂家 价格>

盐酸平阳霉素

盐酸平阳霉素用途

博莱霉素A5盐酸盐是一种抗肿瘤糖蛋白抗生素。博莱霉素A5抑制Drp1介导的线粒体分裂并诱导人鼻息肉源性成纤维细胞凋亡[1][2]。

盐酸平阳霉素名称

[ CAS 号 ]:
55658-47-4

[ 中文名 ]:
盐酸平阳霉素

[ 英文名 ]:
Bleomycin A5 (hydrochloride)

[英文别名 ]:

盐酸平阳霉素生物活性

[ 描述 ]:

博莱霉素A5盐酸盐是一种抗肿瘤糖蛋白抗生素。博莱霉素A5抑制Drp1介导的线粒体分裂并诱导人鼻息肉源性成纤维细胞凋亡[1][2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡
研究领域 >> 癌症
研究领域 >> 感染

[参考文献]

[1]. Yang LC, et al. MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J Oral Pathol Med. 2004;33(1):37-45.

[2]. Wu F, et al. Bleomycin A5 suppresses Drp1 mediated mitochondrial fission and induces apoptosis in human nasal polyp derived fibroblasts. Int J Mol Med. 2021;47(1):346-360.

[3]. Pan JB, et al. Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats. Respirology. 2009;14(7):975-982.

盐酸平阳霉素物理化学性质

[ 密度 ]:
1.56g/cm3

[ 分子式 ]:
C57H90ClN19O21S2

[ 分子量 ]:
1477.02

[ 精确质量 ]:
1475.57000

[ PSA ]:
721.60000

[ 储存条件 ]:
2-8C

盐酸平阳霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EC5990700
CHEMICAL NAME :
Bleomycinamide, N(sup 1)-(3-((4-aminobutyl)amino)propyl)-, hydrochloride
CAS REGISTRY NUMBER :
55658-47-4
LAST UPDATED :
199603
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C57-H89-N19-O21-S2.Cl-H
MOLECULAR WEIGHT :
1477.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
117 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
102 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
66 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
67 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,175,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 mg/kg/8W-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in other cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
35 mg/kg/3W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes primarily in glomeruli
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
40 mg/kg/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death
REFERENCE :
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979

相关化工产品/化学物质：

相关药品：

推荐生产厂家/供应商：

公司名：上海化源生化科技有限公司

区域：上海市普陀区

价格：

联系人：化源网

产品详情：盐酸平阳霉素

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥458.0/10mg ￥22958.0/1g ￥3688.0/100mg

联系人：刘佳

产品详情：盐酸平阳霉素

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥8095.0/25mg ￥2089.0/5mg ￥3685.0/10mg ￥需询单/1g

联系人：李先生

产品详情：Bleomycin A5 (hydrochloride)

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥2299.0/5mg ￥3999.0/10mg ￥需询单/1g ￥需询单/1g

联系人：阿拉丁

产品详情：Bleomycin A5 (hydrochloride)

查看所有供应商请点击：

盐酸平阳霉素供应商

相关化合物

【盐酸平阳霉素】化源网提供盐酸平阳霉素CAS号55658-47-4，盐酸平阳霉素MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询盐酸平阳霉素上化源网，专业又轻松。>>电脑版：盐酸平阳霉素

标题：盐酸平阳霉素_用途_密度_分子量_盐酸平阳霉素CAS号【55658-47-4】_化源网 地址：https://www.chemsrc.com/amp/cas/55658-47-4_399918.html