1-甘露糖野尻霉素盐酸盐

1-甘露糖野尻霉素盐酸盐用途

1-Deoxymannojirimycin hydrochloride 是一种选择性的 I 类 α1,2-甘露糖苷酶 (class I α1,2-mannosidase) 抑制剂,IC50 为 20 μM。1-Deoxymannojirimycin hydrochloride 也是一种 N-联糖基化 (N-linked glycosylation) 抑制剂,可抑制 HIV-1 毒株,具有抗病毒活性。

1-甘露糖野尻霉素盐酸盐名称

[ CAS 号 ]:
73465-43-7

[ 中文名 ]:
1-甘露糖野尻霉素盐酸盐

[ 英文名 ]:
1-Deoxymannojirimycin hydrochloride

[中文别名 ]:

1-脱氧麦诺吉利霉素

[英文别名 ]:

1-deoxymannojirimycin hydrochloride

1-甘露糖野尻霉素盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 流感病毒

信号通路 >> 抗感染 >> HIV

研究领域 >> 感染

[ 靶点 ]

IC50: 20 μM (α1,2-mannosidase I)[1] N-linked glycosylation[2] HIV‐1[2]

[参考文献]

[1]. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98.

[2]. Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4.

1-甘露糖野尻霉素盐酸盐物理化学性质

[ 熔点 ]:
183-185ºC

[ 分子式 ]:
C₆H₁₄ClNO₄

[ 分子量 ]:
199.633

[ 精确质量 ]:
199.061142

[ PSA ]:
92.95000

[ 外观性状 ]:
Powder | white to off-white

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: soluble10mg/mL

1-甘露糖野尻霉素盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
22-24/25-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

1-甘露糖野尻霉素盐酸盐文献

Glycosylation of native MHC class Ia molecules is required for recognition by allogeneic cytotoxic T lymphocytes.

Glycobiology 6 , 413-421, (1996)

The question whether or not target cell N-linked carbohydrate participates in cytotoxic T lymphocyte (CTL) mediated cytolysis has been in contention for well over a decade. Much of the evidence suppor...

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