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谷氨酰胺转移酶

谷氨酰胺转移酶用途

转谷氨酰胺酶是一种在蛋白质分子之间形成交联的酶。转谷氨酰胺酶催化谷氨酰胺残基的γ-甲酰胺基团与不同化合物的一级ε-胺基团之间形成异肽键。转谷氨酰胺酶参与许多生理过程,包括凝血、抗菌免疫反应和光合作用[1]。

谷氨酰胺转移酶名称

[ CAS 号 ]:
80146-85-6

[ 中文名 ]:
转谷氨酰胺酶

[ 英文名 ]:
Transglutaminase

[英文别名 ]:

MFCD00132446

谷氨酰胺转移酶生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

Co2+、Ba2+和K+可提高转谷氨酰胺酶活性[1]。微生物转谷氨酰胺酶被Zn2+、Cu2+、Hg2+和Pb2+离子抑制,这些离子与活性中心的半胱氨酸巯基结合[1]。

谷氨酰胺转移酶物理化学性质

[ 分子式 ]:
C₂₇H₄₄O₃H₂O

[ 外观性状 ]:
lyophilized powder

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: soluble1.0mg/mL, clear

谷氨酰胺转移酶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
22-24/25-26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
MA2370000

谷氨酰胺转移酶文献

Glycation and transglutaminase mediated glycosylation of fish gelatin peptides with glucosamine enhance bioactivity.

Food Chem. 142 , 285-93, (2014)

A mixture of novel glycopeptides from glycosylation between cold water fish skin gelatin hydrolysates and glucosamine (GlcN) via transglutaminase (TGase), as well as glycation between fish gelatin hyd...

Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules.

Am. J. Respir. Cell. Mol. Biol. 50(4) , 737-47, (2014)

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive fibrotic destruction of normal lung architecture. Due to a lack of effective treatment options, new treatment approaches are needed....

Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells.

Biochim. Biophys. Acta 1853(1) , 201-12, (2015)

Tissue transglutaminase (TG2) is a multifunctional protein cross-linking enzyme that has been implicated in apoptotic cell clearance but is also important in many other cell functions including cell a...

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