333963-40-9

• 常用中文名：鲁比前列酮
• 常用英文名：Lubiprostone
• CAS号：333963-40-9
• 分子式：C₂₀H₃₂F₂O₅
• 分子量：390.462
• 相关类别： 生物化工 抑制剂 跨膜转运体(Transmembrane Transporters) CFTR 激活剂
• 发布时间：2018-05-28 08:00:00
• 更新时间：2026-06-30 10:38:00
• Lubiprostone, also known as RU-0211, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM).

名称

• 中文名: 鲁比前列素
• 英文名: (2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid
• 中文别名: 卢比前列腺素; 鲁比前列酮(鲁比前列素); 鲁比前列素333-9333-9; 鲁比前列铜; 鲁比前列素 鲁比前列酮; 鲁比前列酮(卢比前列腺素); 鲁比前列酮对照品; (2R,4,5R,7-2-(1,1-二氟戊基)-2-羟基-6-氧代-3,4,4A,5,7,7A-六氢环戊并[B]吡喃-5-庚酸; 鲁比前列腺; 卢比前列酮; 7-[(1R,2S)-2-(4,4-二氟-3-辛酮基)-5-环戊酮-3-烯-1-基]庚酸; 鲁比前列酮(半缩酮); (2R,4AR,5R,7AR)-2-(1,1-二氟戊基)-2-羟基-6-氧代-3,4,4A,5,7,7A-六氢环戊并[B]吡喃-5-庚酸
• 英文别名: (2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-h; Lubiprostone (Mixture of Tautomeric Isomers); Lubiprostone (Ring Closed); Lubiprostone hemiketal; (-)-7-[(2R,4,5R,7-2-(1,1-difluoropentyl)-2-hydroxy-6- oxooctahydrocyclopenta[b]pyran-5-yl]htanoic acid; Prostaglin Lubiprostone; 7-((2R,4,5R,7aS)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)htanoic acid; Amitiza; AMitiza Lubiprostone; 7-((1R,2S)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopent-3-en-1-yl)htanoic acid; (2R,4,5R,7-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-htanoic acid; 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid; Ruby prostaglandin; UR-021; Lubiprostone-d4; Prostan-1-oic acid, 11,15-oxy-16,16-difluoro-15-hydroxy-9-oxo-, (11α,15R); Prostan-1-oic acid,11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-,(11alpha,15R); Unii-g2R6k; (-)-7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid; (2R,4,5R,7-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-h; 7-[(2R,4,5R,7-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-yl]htanoic acid; Prostan-1-oic acid, 11,15-oxy-16,16-difluoro-15-hydroxy-9-oxo-, (11alpha,15R); Spi 0211; (11α,15R)-16,16-Difluoro-15-hydroxy-9-oxo-11,15-epoxyprostan-1-oic acid; 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yI]heptanoic acid; [3H]-Lubiprostone; Unii-7662kg2R6k; 7-((2R,4,5R,7-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)htanoic acid; 7-((1R,2R,3R)-2-(4,4-difluoro-3-oxooctyl)-3-hydroxy-5-oxocyclopentyl)htanoic acid

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 532.3±50.0 °C at 760 mmHg
• 分子式: C₂₀H₃₂F₂O₅
• 分子量: 390.462
• 闪点: 275.7±30.1 °C
• 精确质量: 390.221771
• PSA: 83.83000
• LogP: 2.85
• 外观性状: 固体
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.486
• 储存条件: -20°C， 干燥

安全

• 危害码 (欧洲): Xn

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