333963-40-9

333963-40-9结构式

常用中文名：鲁比前列酮
常用英文名：Lubiprostone
CAS号：333963-40-9
分子式：C₂₀H₃₂F₂O₅
分子量：390.462
相关类别：生物化工抑制剂跨膜转运体(Transmembrane Transporters) CFTR 激活剂
发布时间：2018-05-28 08:00:00
更新时间：2024-01-03 17:15:19
Lubiprostone, also known as RU-0211, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM).

中文名	鲁比前列素
英文名	(2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid
中文别名	(2R,4AR,5R,7AR)-2-(1,1-二氟戊基)-2-羟基-6-氧代-3,4,4A,5,7,7A-六氢环戊并[B]吡喃-5-庚酸鲁比前列酮卢比前列酮
英文别名	(2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-h 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid Prostan-1-oic acid, 11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-, (11α,15R)- Spi 0211 Lubiprostone Prostan-1-oic acid,11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-,(11alpha,15R) (11α,15R)-16,16-Difluoro-15-hydroxy-9-oxo-11,15-epoxyprostan-1-oic acid 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yI]heptanoic acid [3H]-Lubiprostone Unii-7662kg2R6k (-)-7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid

危害码 (欧洲)	Xn

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