13797-77-8

• 常用中文名：5-甲氧基噻唑并[5,4-b]吡啶-2-胺
• 常用英文名：5-methoxy-[1,3]thiazolo[5,4-b]pyridin-2-amine
• CAS号：13797-77-8
• 分子式：C₇H₇N₃OS
• 分子量：181.21500
• 发布时间：2018-05-31 08:00:00
• 更新时间：2024-01-13 02:09:08

名称

• 中文名: 5-甲氧基三阿咪唑
• 英文名: 5-methoxy-[1,3]thiazolo[5,4-b]pyridin-2-amine
• 中文别名: 5-甲氧基噻唑并[5,4-b]吡啶-2-胺
• 英文别名: 5-(methyloxy)[1,3]thiazolo[5,4-b]pyridin-2-amine; 5-METHOXYTHIAZOLO[5,4-B]PYRIDIN-2-AMINE; 5-Methoxythiazolo[5,4-b]pyridine-2-amine; 5-Methoxy[1,3]thiazolo[5,4-b]pyridin-2-amine; 5-Methoxy-thiazolo[5,4-b]pyridin-2-ylamin; 5-methoxypyrido[3,2-d][1,3]thiazol-2-amine; 2-Amino-5-methoxythiazolo<5,4-b>pyridine; 2-amino-6-methoxythiazolo<5,4-b>pyridine; 5-methoxy-thiazolo[5,4-b]pyridin-2-ylamine

物化性质

• 沸点: 335.1±45.0 °C at 760 mmHg
• 熔点: 193ºC
• 分子式: C₇H₇N₃OS
• 分子量: 181.21500
• 精确质量: 181.03100
• PSA: 89.27000
• LogP: 1.86330
• 外观性状: 固体
• 储存条件: 2-8°C， 避光

MSDS

Name: 5-Methoxypyrido[3 2-d][1 3]thiazol-2-amine 97% Material Safety Data Sheet Synonym: CAS: 13797-77-8 Section 1 - Chemical Product MSDS Name:5-Methoxypyrido[3 2-d][1 3]thiazol-2-amine 97% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 13797-77-8 5-Methoxypyrido[3,2-d][1,3]thiazol-2-a 97% unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 13797-77-8: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: Not available. Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 193 - 194 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C7H7N3OS Molecular Weight: 181.21 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 13797-77-8 unlisted. LD50/LC50: Not available. Carcinogenicity: 5-Methoxypyrido[3,2-d][1,3]thiazol-2-amine - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 13797-77-8: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 13797-77-8 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 13797-77-8 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi:Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S37/39
• 海关编码: 2934999090

合成路线

6628-77-9 333-20-0 ~87% 13797-77-8

文献：Journal of Medicinal Chemistry, , vol. 52, # 19 p. 6142 - 6152

6628-77-9 ~% 13797-77-8

文献：WO2004/50645 A1, ; Page 34-35 ; WO 2004/050645 A1

13534-97-9 67-56-1 ~% 13797-77-8

文献：WO2007/41366 A1, ; Page/Page column 36 ; WO 2007/041366 A1

6628-77-9 505-14-6 ~% 13797-77-8

文献：Chemical and Pharmaceutical Bulletin, , vol. 30, # 1 p. 302 - 318

5446-92-4 ~% 13797-77-8

文献：Chemical and Pharmaceutical Bulletin, , vol. 30, # 1 p. 302 - 318

38533-61-8 17356-08-0 ~7% 13797-77-8

文献：Journal of Heterocyclic Chemistry, , vol. 46, # 6 p. 1125 - 1131

6628-77-9 540-72-7 ~% 13797-77-8

文献：Journal of Heterocyclic Chemistry, , vol. 20, # 1 p. 199 - 203

4548-45-2 ~% 13797-77-8

文献：WO2013/91502 A1, ;

上下游产品

上游产品  9
6628-77-9 333-20-0 13534-97-9 67-56-1
505-14-6 5446-92-4 38533-61-8 540-72-7
4548-45-2
下游产品  2
81587-43-1 42362-27-6

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%