322-35-0

• 常用中文名：苄丝肼
• 常用英文名：2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide
• CAS号：322-35-0
• 分子式：C₁₀H₁₅N₃O₅
• 分子量：257.24300
• 相关类别： 原料药 神经系统用药 抗震颤麻痹药
• 发布时间：2018-03-09 08:00:00
• 更新时间：2026-07-13 07:23:10
• 用于神经药理、生理研究，抑制多巴胺脱羧反应。

名称

• 中文名: 苄丝肼
• 英文名: benserazide
• 中文别名: 丧生; 苄丝肼杂质; 色拉肼羟苄丝肼; DL-丝氨酰(2,3,4-三羟基苄基)肼盐酸盐; 苄丝肼-D3; 羟苯丝肼; 多巴丝肼杂质; 三羟苄基丝氨酰肼; 2-氨基-3-羟基-2'-(2,3,4-三羟基苄基)丙酰肼; 苯柳氮-D3; 盐酸苄丝肼-D3 HCL
• 英文别名: BENSERASZIDE; Benzyserazine; 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide; Ro 4-4602; evodopa and Benserazide; BENSERAZIDE; Benserazide Hydrochloride 14-8 / Base; 2-amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide; 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propionohydrazide; Serine, 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide; DL-Serine 2-[2,3,4-trihydroxybenzyl] hydrazide; bensarazide; DL-Seryltrihydroxybenzylhydrazine; BenserazideBase; Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide, DL- (8CI); 2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide //BP; Benserazide analogue: 1-(2,3,4-trihydroxybenzyl)-2-Methylhydrazine; 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide; 2-azanyl-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide; Benserazidum; N-(DL-Seryl)-N'-(2,3,4-trihydroxybenzyl)hydrazine; N1-(DL-Seryl)-N2-(2,3,4-trihydroxybenzyl)hydrazine; Benserazide Metabolite: 2,3,4-trihydroxybenzylhydrazine; MFCD00242633; evodopa and Benserazide //BP; dl-seryltrihydroxybenzylhydrazine; dl-serine,2-((2,3,4-trihydroxyphenyl)methyl)hydrazide; Serine, 2-(2,3,4-trihydroxybenzyl)hydrazide (7CI); Levodopa Impurity 8; Benseraszide; Benserazida; 2-(2,3,4-trihydroxybenzyl)hyrazide,dl-serin; Serazide

物化性质

• 密度: 1.541 g/cm3
• 沸点: 574.2ºC at 760 mmHg
• 分子式: C₁₀H₁₅N₃O₅
• 分子量: 257.24300
• 闪点: 301ºC
• 精确质量: 257.10100
• PSA: 148.07000
• 折射率: 1.678

生物活性

• 描述: Benserazide 是一种 PKM2 抑制剂。 Benserazide 直接结合并阻断 PKM2 酶活性,从而抑制有氧糖酵解,同时上调 OXPHOS。Benserazide可用于黑色素瘤的研究。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Zhou Y, et al. Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2020 Jul 1;147(1):139-151.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VT9632200 CHEMICAL NAME : Serine, 2-(2,3,4-trihydroxybenzyl)hyrazide, DL- CAS REGISTRY NUMBER : 322-35-0 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C10-H15-N3-O5 MOLECULAR WEIGHT : 257.28 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 23400 mg/kg/90D-C TOXIC EFFECTS : Behavioral - ataxia Kidney, Ureter, Bladder - other changes in urine composition Musculoskeletal - other changes REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2880 mg/kg SEX/DURATION : female 90 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26
• 海关编码: 2928000090

海关

海关编码	2928000090
中文概述	2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%