17598-65-1

• 常用中文名：去乙酰毛花苷
• 常用英文名：Deslanoside
• CAS号：17598-65-1
• 分子式：C₄₇H₇₄O₁₉
• 分子量：943.079
• 相关类别： 原料药 循环系统用药 抗充血性心力衰竭药
• 发布时间：2018-03-03 08:00:00
• 更新时间：2026-07-02 07:25:51
• Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,用于治疗充血性心力衰竭和因折返机制引起的室上性心律失常,并在治疗慢性心房颤动时控制心室率。Deslanoside 抑制Na-K-ATPase膜泵,导致细胞内钠和钙浓度增加。

名称

• 中文名: 去乙酰毛花苷
• 英文名: deslanoside
• 中文别名: 脱乙酰基葡糖苷C; 地兰苷; Deslanoside #天然产物 HY-A0154; 去乙酰毛花苷/西地兰D/去乙酰西地兰/毛花洋地黄苷C/毛花强心丙; 毛花强心苷丙; 西地兰; Deslanoside :西地兰，去乙酰毛花苷; 去乙酰毛花苷/西地兰; 毛花洋地黄苷C; Deslanoside :西地兰,去乙酰毛花苷; 去乙酰毛花苷丙; 去乙酰西地兰,10 MM DMSO 溶液; 去乙酰毛花苷,毛花洋地黄苷C; 去乙酰毛花苷 标准品; 乙酰地谷新葡萄糖苷; 去乙酰西地兰; 毛地黄苷C
• 英文别名: eslanoside; Deslanoside, 10 mM in DMSO; De-O-acetyllanatoside C; Deacetyllanatoside C; Deslanatoside C; Deacetyllanatoside C,Desacetyllanatoside C; desacetyllanatosidec; (3β,5β,12β)-3-{[β-D-Glucopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide; deacetyl-lanatoside; Descetyldigilanide C; DESLANOSIDUM; Cd-20(22)-enolide, 3-[(O-β-D-glucopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β); descetyldigilanidec; 4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-3-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2(5H)-furanone; Desaci; DESLANOSIDE; Deacetylanatoside C; Desace; MFCD00135818; Desacetyllanatosid C; glucodigoxin; Deslanoside //BP; Purpurea glycoside C; Deslanoside CRS; Deslanosidum C; (3β,5β,12β)-3-{[β-D-Glucopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy}-12,14-dihydro
 xycard-20(22)-enolide; cedilanidd; sediranido; EINECS 241-568-1; DEACETYLLANATOSIDE C; Desacetyllanatoside C; Deslanoside RS; Cedilanide; Deslanoside (JP14; 4-18-00-02455 (Beilstein Handbook Reference); Desacetyldigilanide C; deslanatoside; Methyl Salicylate Impurity 8; deacetyl-lanatoside C; 17-1 Deslanoside; Deslanatoside; Purpurea Glycoside C; Desacetyl-Lanatosid C; Lanatoside C, deacetyl- (6CI, 7CI, 8CI); Deslanoside C; Deacetyl-lanotoside C; 4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-dihydroxy-3-[(2R,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-5-[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one; 4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-3-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-méthyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}tétrahydro-2H-pyran-2-yl]oxy}-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-10,13-diméthylhexadécahydro-1H-cyclopenta[a]phénanthrén-17-yl]-2(5H)-furanone; de-O-acetyl-lanatoside C; 4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-3-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2(5H)-furanon

物化性质

• 密度: 1.4±0.1 g/cm3
• 熔点: 220-235ºC
• 分子式: C₄₇H₇₄O₁₉
• 分子量: 943.079
• 精确质量: 942.482422
• PSA: 282.21000
• LogP: -1.40
• 折射率: 1.620
• 储存条件: 2-8°C

生物活性

• 描述: Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,用于治疗充血性心力衰竭和因折返机制引起的室上性心律失常,并在治疗慢性心房颤动时控制心室率。Deslanoside 抑制Na-K-ATPase膜泵,导致细胞内钠和钙浓度增加。
• 相关类别:
  研究领域 >> 心血管疾病
• 体外研究: 去乙酰甲苷(Desacetyllanatoside C)是兰豆苷C的代谢产物[4]。地塞米松增加前臂血流量和心脏指数,降低心率,同时骨骼肌交感神经活动显著降低,作为中枢介导交感神经系统活动的指标[1]。
• 参考文献:

  [1]. Hauptman PJ, et al. Digitalis. Circulation. 1999 Mar 9;99(9):1265-70.

  [2]. Wang L, et al. Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China. Sci Rep. 2017 Oct 23;7(1):13819.

  [3]. Deslanoside.

  [4]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.

  [5]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OE2100500 CHEMICAL NAME : Lanatoside C, deacetyl- CAS REGISTRY NUMBER : 17598-65-1 BEILSTEIN REFERENCE NO. : 0078187 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C47-H74-O19 MOLECULAR WEIGHT : 943.21 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10360 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,489,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,489,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 230 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,190,1963 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,190,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7349 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 103 (estimated) No. of Female Employees: 52 (estimated)

安全

• 风险声明 (欧洲): R23/25
• 安全声明 (欧洲): 1-22-45
• 危险品运输编码: UN 2811

合成路线

17575-22-3 ~% 17598-65-1

文献：Helvetica Chimica Acta, , vol. 16, p. 1390,1407 Helvetica Chimica Acta, , vol. 17, p. 592,613

20830-75-5 572-09-8 ~% 17598-65-1

文献：Advanced Synthesis and Catalysis, , vol. 355, # 13 p. 2518 - 2524

1469804-92-9 ~91% 17598-65-1

文献：Muramatsu, Wataru; Yoshimatsu, Hirofumi Advanced Synthesis and Catalysis, 2013 , vol. 355, # 13 p. 2518 - 2524

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