76622-84-9

• 常用中文名：人源Β型内吗啡肽片段多肽
• 常用英文名：δ-Endorphin (human)
• CAS号：76622-84-9
• 分子式：C₁₃₉H₂₁₇N₃₃O₄₀S
• 分子量：3022.47
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 阿片受体
• 发布时间：2017-11-13 01:17:52
• 更新时间：2026-07-16 10:25:07
• β-Endorphin (1-27) (human) 是一种 opioid 拮抗剂,结合 μ-、δ- 和 κ-阿片受体,其 Kis 分别为 5.31、6.17 和 39.82 nM。β-Endorphin (1-27) (human) 抑制 β-Endorphin (HY-P1502) 诱导和 etorphine 诱导的痛觉缺失。

名称

• 中文名: 人源Β型内吗啡肽片段多肽
• 英文名: δ-Endorphin (human)
• 中文别名: 人β-内啡肽; 乙酰基-DELTA-内啡肽(人)
• 英文别名: d-Endorphin (huMan); Δ-ENDORPHIN (HUMAN); B-endorphin fragment; B-ENDORPHIN FRAGMENT , HUMAN; β-Endorphin , human; H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-OH; AC-DELTA-ENDORPHIN (HUMAN); β-Endorphin (she, 27-L-tyrosine; BETA-ENDORPHIN, FRAGMENT; ACETYL, BETA-ENDORPHIN , HUMAN; fragment; δ-Endorphin (huMan) β-Lipotropin (huMan), β-Endorphin (huMan), Lipotropin C' FragMent (huMan); ACETYL-TYR-GLY-GLY-PHE-MET-THR-SER-GLU-LYS-SER-GLN-THR-PRO-LEU-VAL-THR-LEU-PHE-LYS-ASN-ALA-ILE-ILE-LYS-ASN-ALA-TYR-OH; β-Endorphin (human); 5-[[5-amino-1-[[2-[[4-amino-1-[[1-[2-[[1-[[1-[[1-[[1-[[2-[[5-amino-1-[[3-amino-1-[[2-[[1-[[1-[[5-amino-1-[[3-amino-1-[[2-[[1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]carbamoyl]pentyl]carbamoyl]-2-methyl-butyl]carbamoyl]-2-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]carbamoyl]pentyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]pyrrolidine-1-carbonyl]-2-hydroxy-propyl]carbamoyl]-4-oxo-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]pentyl]amino]-4-[[2-[[2-[[2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]amino]-5-oxo-pentanoic acid; beta-endorphin, human, fragment; b-Lipotropin (huMan), b-Endorphin (huMan), Lipotropin C' FragMent (huMan); beta-Endorphin huMan fragMent 1-27; Acetyl, b-Endorphin; β-endorphin human fragment

物化性质

• 分子式: C₁₃₉H₂₁₇N₃₃O₄₀S
• 分子量: 3022.47
• 精确质量: 3020.57000
• PSA: 1222.67000
• LogP: 3.79500

生物活性

• 描述: β-Endorphin (1-27) (human) 是一种 opioid 拮抗剂,结合 μ-、δ- 和 κ-阿片受体,其 Kis 分别为 5.31、6.17 和 39.82 nM。β-Endorphin (1-27) (human) 抑制 β-Endorphin (HY-P1502) 诱导和 etorphine 诱导的痛觉缺失。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
  研究领域 >> 神经疾病
• 靶点:

  Ki: 5.31 nM (μ-opioid receptor), 6.17 nM (δ-opioid receptor), 39.82 nM (κ-opioid receptor)[1]

• 参考文献:

  [1]. Mansour A, et al. The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores. Brain Res. 1995 Nov 27;700(1-2):89-98.

  [2]. Nicolas P, et al. Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia. Proc Natl Acad Sci U S A. 1985 May;82(10):3178-81.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3