475205-49-3

• 常用中文名：A-317491
• 常用英文名：A-317491
• CAS号：475205-49-3
• 分子式：C₃₃H₂₇NO₈
• 分子量：565.56900
• 相关类别： 信号通路 自噬 自噬
• 发布时间：2017-06-10 03:33:51
• 更新时间：2024-01-11 12:41:52
• A-317491是非核苷酸类P2X3和P2X2/3受体拮抗剂，能抑制由其介导的钙流。

名称

• 中文名: A-317491
• 英文名: 5-[(3-phenoxyphenyl)methyl-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid
• 英文别名: cs-1250; A-317491

物化性质

• 分子式: C₃₃H₂₇NO₈
• 分子量: 565.56900
• 精确质量: 565.17400
• PSA: 141.44000
• LogP: 6.29350
• 储存条件: -20°C

生物活性

• 描述: A-317491是非核苷酸类P2X3和P2X2/3受体拮抗剂,能抑制由其介导的钙流。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 跨膜转运 >> P2X受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hansen RR, Nasser A, Falk S, et al. Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice. Eur J Pharmacol. 2012 Aug 5;688(1-3):27-34.

  [2]. Wu JX, Xu MY, Miao XR, et al. Functional up-regulation of P2X3 receptors in dorsal root ganglion in a rat model of bone cancer pain. Eur J Pain. 2012;16(10):1378-88.

  [3]. Xu J, Chu KL, Brederson JD, et al. Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats. J Neurosci Res. 2012;90(8):1597-606.

  [4]. Yasuda M, Shinoda M, Kiyomoto M, et al. P2X3 receptor mediates ectopic mechanical allodynia with inflamed lower lip in mice. Neurosci Lett. 2012 18;528(1):67-72.

  [5]. Maria Cláudia G. Oliveiraa, Adriana Pelegrini-da-Silvaa, et al. Peripheral mechanisms underlying the essential role of P2X3,2/3 receptors in the development of inflammatory hyperalgesia. PAIN. 2009,141(1-2): 127-134.

  [6]. Yuan M, et al. Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain. Int J Nanomedicine. 2017 Nov 9;12:8171-8183.