A-317491

Q: A-317491的储存条件是什么？

A-317491储存条件：-20°C。

更新时间：2026-07-04 19:30:31

A-317491结构式	常用名	A-317491	英文名	A-317491
	CAS号	475205-49-3	分子量	565.56900
	密度	N/A	沸点	N/A
	分子式	C₃₃H₂₇NO₈	熔点	N/A
	MSDS	N/A	闪点	N/A

A-317491用途

A-317491是非核苷酸类P2X3和P2X2/3受体拮抗剂,能抑制由其介导的钙流。

本表展示该化学物质的中文名称、英文系统名、各类中文与英文别名信息。

中文名	A-317491
英文名	5-[(3-phenoxyphenyl)methyl-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid
英文别名	更多

本表记录该化合物相关生物活性、作用靶点、活性说明与生物实验相关数据。

描述	A-317491是非核苷酸类P2X3和P2X2/3受体拮抗剂,能抑制由其介导的钙流。
相关类别	信号通路 >> 自噬 >> 自噬信号通路 >> 跨膜转运 >> P2X受体研究领域 >> 神经疾病
参考文献	[1]. Hansen RR, Nasser A, Falk S, et al. Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice. Eur J Pharmacol. 2012 Aug 5;688(1-3):27-34. [2]. Wu JX, Xu MY, Miao XR, et al. Functional up-regulation of P2X3 receptors in dorsal root ganglion in a rat model of bone cancer pain. Eur J Pain. 2012;16(10):1378-88. [3]. Xu J, Chu KL, Brederson JD, et al. Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats. J Neurosci Res. 2012;90(8):1597-606. [4]. Yasuda M, Shinoda M, Kiyomoto M, et al. P2X3 receptor mediates ectopic mechanical allodynia with inflamed lower lip in mice. Neurosci Lett. 2012 18;528(1):67-72. [5]. Maria Cláudia G. Oliveiraa, Adriana Pelegrini-da-Silvaa, et al. Peripheral mechanisms underlying the essential role of P2X3,2/3 receptors in the development of inflammatory hyperalgesia. PAIN. 2009,141(1-2): 127-134. [6]. Yuan M, et al. Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain. Int J Nanomedicine. 2017 Nov 9;12:8171-8183.

描述

A-317491是非核苷酸类P2X3和P2X2/3受体拮抗剂,能抑制由其介导的钙流。

相关类别

信号通路 >> 自噬 >> 自噬

信号通路 >> 跨膜转运 >> P2X受体

研究领域 >> 神经疾病

参考文献

[1]. Hansen RR, Nasser A, Falk S, et al. Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice. Eur J Pharmacol. 2012 Aug 5;688(1-3):27-34.

[2]. Wu JX, Xu MY, Miao XR, et al. Functional up-regulation of P2X3 receptors in dorsal root ganglion in a rat model of bone cancer pain. Eur J Pain. 2012;16(10):1378-88.

[3]. Xu J, Chu KL, Brederson JD, et al. Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats. J Neurosci Res. 2012;90(8):1597-606.

[4]. Yasuda M, Shinoda M, Kiyomoto M, et al. P2X3 receptor mediates ectopic mechanical allodynia with inflamed lower lip in mice. Neurosci Lett. 2012 18;528(1):67-72.

[5]. Maria Cláudia G. Oliveiraa, Adriana Pelegrini-da-Silvaa, et al. Peripheral mechanisms underlying the essential role of P2X3,2/3 receptors in the development of inflammatory hyperalgesia. PAIN. 2009,141(1-2): 127-134.

[6]. Yuan M, et al. Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain. Int J Nanomedicine. 2017 Nov 9;12:8171-8183.

本表包含该物质理化参数，如熔点、沸点、密度、溶解度、旋光性等理化指标，无数据项标记为N/A。

分子式	C₃₃H₂₇NO₈
分子量	565.56900
精确质量	565.17400
PSA	141.44000
LogP	6.29350
InChIKey	VQGBOYBIENNKMI-LJAQVGFWSA-N
SMILES	O=C(O)c1cc(C(=O)O)c(C(=O)N(Cc2cccc(Oc3ccccc3)c2)C2CCCc3ccccc32)cc1C(=O)O
储存条件	-20°C

本表记录该化合物靶点、体外体内实验、生物测定实验相关实验数据。

实验名称：Intrinsic clearance in human liver microsomes at 1 to 2.5 uM in presence of NADPH
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4427198

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4513082

实验名称：Human P2X3 (P2X receptors)
来源：IUPHAR-DB
靶标：P2X3 (P2X receptors) [Homo sapiens]
External Id：480_Human

实验名称：Antagonist activity at recombinant human P2X3 receptor expressed in Xenopus oocytes a...
来源：ChEMBL
靶标：P2X purinoceptor 3
External Id：CHEMBL3096841

实验名称：qHTS for Inhibitors of Polymerase Kappa
来源：NCGC
靶标：DNA polymerase kappa [Homo sapiens]
External Id：PolK100

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
来源：ChEMBL
靶标：Replicase polyprotein 1ab
External Id：CHEMBL4495582

实验名称：Antagonist activity at human recombinant P2X3 receptor expressed in HEK293-Tet-on cel...
来源：ChEMBL
靶标：P2X purinoceptor 3
External Id：CHEMBL4427195

实验名称：HIV Cellular Data
来源：NIAID
靶标：N/A
External Id：HIV Cellular Data

实验名称：Kinetic solubility of the compound in phosphate buffer at pH 7.4 by HPLC analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4427197

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本表罗列该化合物全部英文别名、系统命名、CAS别名等英文名称集合。

cs-1250

A-317491

本部分为该化合物相关常见问答，包含基础参数、性状、储存条件等高频咨询问题与对应答案。

Q: A-317491的极性表面积PSA是多少？

A: A-317491极性表面积PSA为141.44000。

Q: A-317491的分子量是多少？

A: A-317491分子量为565.56900。

Q: A-317491的LogP（油水分配系数）是多少？