A-317491

• 常用名: A-317491
• 英文名: A-317491
• CAS号: 475205-49-3
• 分子量: 565.56900
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₃H₂₇NO₈
• 熔点: N/A
• 闪点: N/A

A-317491用途

A-317491是非核苷酸类P2X3和P2X2/3受体拮抗剂，能抑制由其介导的钙流。

A-317491名称

• 中文名: A-317491
• 英文名: 5-[(3-phenoxyphenyl)methyl-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid

A-317491生物活性

• 描述: A-317491是非核苷酸类P2X3和P2X2/3受体拮抗剂,能抑制由其介导的钙流。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 跨膜转运 >> P2X受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hansen RR, Nasser A, Falk S, et al. Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice. Eur J Pharmacol. 2012 Aug 5;688(1-3):27-34.

  [2]. Wu JX, Xu MY, Miao XR, et al. Functional up-regulation of P2X3 receptors in dorsal root ganglion in a rat model of bone cancer pain. Eur J Pain. 2012;16(10):1378-88.

  [3]. Xu J, Chu KL, Brederson JD, et al. Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats. J Neurosci Res. 2012;90(8):1597-606.

  [4]. Yasuda M, Shinoda M, Kiyomoto M, et al. P2X3 receptor mediates ectopic mechanical allodynia with inflamed lower lip in mice. Neurosci Lett. 2012 18;528(1):67-72.

  [5]. Maria Cláudia G. Oliveiraa, Adriana Pelegrini-da-Silvaa, et al. Peripheral mechanisms underlying the essential role of P2X3,2/3 receptors in the development of inflammatory hyperalgesia. PAIN. 2009,141(1-2): 127-134.

  [6]. Yuan M, et al. Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain. Int J Nanomedicine. 2017 Nov 9;12:8171-8183.

A-317491物理化学性质

• 分子式: C₃₃H₂₇NO₈
• 分子量: 565.56900
• 精确质量: 565.17400
• PSA: 141.44000
• LogP: 6.29350
• InChIKey: VQGBOYBIENNKMI-LJAQVGFWSA-N
• SMILES: O=C(O)c1cc(C(=O)O)c(C(=O)N(Cc2cccc(Oc3ccccc3)c2)C2CCCc3ccccc32)cc1C(=O)O
• 储存条件: -20°C

A-317491靶点实验

查看更多实验

实验名称：Intrinsic clearance in human liver microsomes at 1 to 2.5 uM in presence of NADPH 来源：ChEMBL 靶标：N/A External Id：CHEMBL4427198

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Human P2X3 (P2X receptors) 来源：IUPHAR-DB 靶标：P2X3 (P2X receptors) [Homo sapiens] External Id：480_Human

实验名称：Antagonist activity at recombinant human P2X3 receptor expressed in Xenopus oocytes a... 来源：ChEMBL 靶标：P2X purinoceptor 3 External Id：CHEMBL3096841

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Antagonist activity at human recombinant P2X3 receptor expressed in HEK293-Tet-on cel... 来源：ChEMBL 靶标：P2X purinoceptor 3 External Id：CHEMBL4427195

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Kinetic solubility of the compound in phosphate buffer at pH 7.4 by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4427197

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A-317491英文别名

• cs-1250
• A-317491