1018899-04-1

• 常用中文名：索格列净
• 常用英文名：LX-4211
• CAS号：1018899-04-1
• 分子式：C₂₁H₂₅ClO₅S
• 分子量：424.938
• 相关类别： 信号通路 跨膜转运 SGLT
• 发布时间：2018-11-22 11:54:33
• 更新时间：2026-06-30 11:03:20
• LX-4211是SGLT1/2抑制剂,是抗糖尿病剂。

名称

• 中文名: (2S,3R,4R,5S,6R)-2-(4-氯-3-(4-乙氧基苄基)苯基)-6-(甲基硫代)四氢-2H-吡喃-3,4,5-三醇
• 英文名: (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol
• 中文别名: LX4211, 一种SGLT1/2抑制剂; Sotagliflozin (LX4211) 索格列净，S8103; (2S,3R,4R,5S,6R)-2-(4-氯-3-(4-乙氧基苄基)苯基)-6-(; (2S,3R,4R,5S,6R)-2-(4-氯-3-(4-乙氧基苄基)苯基)-6-(甲硫基)四氢-2H-吡喃-3,4,5 - 三醇; 索格列净原料(科研专用); (2S,3R,4R,5S,6R)-2-(4-氯-3-(4-乙氧基苄基)苯基)-6-(甲硫基)四氢-2; 索格列净 Sotagliflozin; 索格列净 Ⅰ晶; LX-4211/索格列净; LX-4211,双重SGLT1/SGLT2抑制剂; 索格列净原料; 抑制剂LX4211; 化合物：LX-4211; 糖; 索格列净/LX-4211; Sotagliflozin (LX4211) 索格列净,S8103; 企业内控版本,欢迎咨询张军; 化合物:LX-4211
• 英文别名: (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(methylsulfanyl)tetrahydro-2-H-pyran-3,4,5-triol; EOS-61381; (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxy-benzyl)-phenyl]-6-methylsulfanyl-tetrahydro-pyran-3,4,5-triol; LX4211; LX 4211; LX4211; LX; LX4211; Sotagliflozin lx4211; Bifrunox Impurity 42; LX4211/Sotagliflozin-API; Sotagliflozin; sotagliflozin; LX-4211 (sotagliflozin); β-L-Xylopyranoside,methyl5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-,(5S); β-L-Xylopyranoside, methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-, (5S); Sotagliflozin,LX-4211, LP-802034, LX4211, LP802034; (5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-1-thio-beta-L-xylopyranoside; LX4211 - L10525; Methyl (5S)-5-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1-thio-β-L-xylopyranoside; UNII-6B4ZBS263Y; (5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside Sotagliflozin LP; LX4211/LX-4211; LX4211 a potent dual SGLT2/1 inhibitor; CS-1069; LX 4211; Zabofloxacin Hydrochloride; LX421; Sotagliflozin, must; LX-4211|||LP-802034; (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(Methylthio)tetrahydro-2H-pyran-3,4,5-triol; Sotagliflozin,0.99; LP-802034; LX-4211, >=; (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol; SOTA-009; Sotagliflozin, 10 mM in DMSO

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 607.9±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₅ClO₅S
• 分子量: 424.938
• 闪点: 321.4±31.5 °C
• 精确质量: 424.111115
• PSA: 104.45000
• LogP: 5.63
• 外观性状: 白色至类白色固体
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.642
• 储存条件: -20℃

生物活性

• 描述: LX-4211是SGLT1/2抑制剂,是抗糖尿病剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> SGLT
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Zambrowicz B, et al. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther. 2012 Aug;92(2):158-69.

  [2]. Powell DR, et al. LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose. J Pharmacol Exp Ther. 2013 May;345(2):250-9.