491-60-1

• 常用中文名：大黄素蒽酮
• 常用英文名：Emodinanthrone
• CAS号：491-60-1
• 分子式：C₁₅H₁₂O₄
• 分子量：256.25300
• 相关类别： 研究领域 感染
• 发布时间：2018-05-07 08:00:00
• 更新时间：2024-01-03 18:31:56
• 大黄素蒽酮是一种蒽醌,是大黄素的一种衍生物,具有抗菌活性。大黄素蒽酮在大肠杆菌[1][2][3]的膜泡中以微摩尔浓度抑制呼吸驱动的溶质运输。

名称

• 中文名: 大黄素蒽酮
• 英文名: 1,3,8-trihydroxy-6-methyl-10H-anthracen-9-one
• 英文别名: 1,3,8-Trihydroxy-6-methyl-anthron; 6-methyl-1,3,8-trihydroxy-10H-anthracene-9-one; Emodinanthrone; 1,3,8-trihydroxy-6-methyl-anthrone

物化性质

• 密度: 1.471 g/cm3
• 沸点: 556.2ºC at 760 mmHg
• 熔点: 254-258 °C(dec.)
• 分子式: C₁₅H₁₂O₄
• 分子量: 256.25300
• 精确质量: 256.07400
• PSA: 77.76000
• LogP: 2.24700
• 蒸汽压: 5.6E-13mmHg at 25°C
• 折射率: 1.723
• 储存条件: 2-8°C，干燥，密封

生物活性

• 描述: 大黄素蒽酮是一种蒽醌,是大黄素的一种衍生物,具有抗菌活性。大黄素蒽酮在大肠杆菌[1][2][3]的膜泡中以微摩尔浓度抑制呼吸驱动的溶质运输。
• 相关类别:
  研究领域 >> 感染
• 体外研究: 大黄素蒽酮用作AknX加氧酶测定的替代底物[1]。
• 参考文献:

  [1]. Jin-Young Chung, et al. Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus. J Bacteriol. 2002 Nov;184(22):6115-22.

  [2]. T Ubbink-Kok, et al. Inhibition of electron transfer and uncoupling effects by emodin and emodinanthrone in Escherichia coli. Antimicrob Agents Chemother. 1986 Jul;30(1):147-51.

  [3]. M K Wang, et al. Triterpenoid saponins from Berneuxia thebetica. Phytochemistry. 1998 Aug;48(8):1411-4.

安全

• 危害码 (欧洲): Xi

合成路线

518-82-1 ~96% 491-60-1

文献：HY BIOPHARMA, INC.; TOBIA, Alfonso, J.; CABANA, Bernard, E.; VADLAPATLA, Venkata; CONNOLLY, Ronald, H. Patent: WO2011/34922 A1, 2011 ; Location in patent: Page/Page column 9 ;

33770-95-5 ~87% 491-60-1

文献：Liang, Jing Lu; Cha, Hyo Chang; Lee, Seung Ho; Son, Jong-Keun; Chang, Hyeun Wook; Eom, Ji-Eun; Kwon, Youngjoo; Jahng, Yurngdong Archives of Pharmacal Research, 2012 , vol. 35, # 3 p. 447 - 454

6030-60-0 ~% 491-60-1

文献：Liang, Jing Lu; Cha, Hyo Chang; Lee, Seung Ho; Son, Jong-Keun; Chang, Hyeun Wook; Eom, Ji-Eun; Kwon, Youngjoo; Jahng, Yurngdong Archives of Pharmacal Research, 2012 , vol. 35, # 3 p. 447 - 454

1373404-37-5 ~% 491-60-1

文献：Liang, Jing Lu; Cha, Hyo Chang; Lee, Seung Ho; Son, Jong-Keun; Chang, Hyeun Wook; Eom, Ji-Eun; Kwon, Youngjoo; Jahng, Yurngdong Archives of Pharmacal Research, 2012 , vol. 35, # 3 p. 447 - 454

481-73-2 ~% 491-60-1

文献：Anslow; Breen; Raistrick Biochemical Journal, 1940 , vol. 34, p. 159,165

517-48-6 ~% 491-60-1

文献：Oxford; Raistrick Biochemical Journal, 1940 , vol. 34, p. 790,799

481-73-2 10034-85-2 64-19-7 ~% 491-60-1

文献：Anslow; Breen; Raistrick Biochemical Journal, 1940 , vol. 34, p. 159,165

21871-90-9 10034-85-2 108-24-7 ~% 491-60-1

文献：Eder Archiv der Pharmazie (Weinheim, Germany), 1915 , vol. 253, p. 32 Archiv der Pharmazie (Weinheim, Germany), 1916 , vol. 254, p. 18,30 Full Text Show Details Tutin; Clewer Journal of the Chemical Society, 1912 , vol. 101, p. 294

96822-98-9 ~% 491-60-1

文献：Liang, Jing Lu; Cha, Hyo Chang; Lee, Seung Ho; Son, Jong-Keun; Chang, Hyeun Wook; Eom, Ji-Eun; Kwon, Youngjoo; Jahng, Yurngdong Archives of Pharmacal Research, 2012 , vol. 35, # 3 p. 447 - 454

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