147098-20-2

• 常用中文名：瑞舒伐他汀钙
• 常用英文名：Rosuvastatin Calcium
• CAS号：147098-20-2
• 分子式：C₄₄H₅₄CaF₂N₆O₁₂S₂
• 分子量：1001.1
• 相关类别： 原料药 循环系统用药 调节血脂药
• 发布时间：2018-06-06 23:48:32
• 更新时间：2026-07-01 11:39:27
• Rosuvastatin钙盐是HMG-CoA还原酶抑制剂,IC50为11 nM。

名称

• 中文名: 罗苏伐他汀钙
• 英文名: Rosuvastatin Calcium
• 中文别名: (+)-(3R,5S)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰基氨基)嘧啶 -5-基]-3,5-二羟基-6-(E)-庚烯酸钙; 瑞舒伐他汀钙 (+)-(3R,5S)-7-[4-(4- 氟苯基 )-6- 异丙基 -2-(N- 甲基 -N- 甲磺酰基氨基 ) 嘧啶 -5- 基 ]-3,5- 二羟基 -6-(E)- 庚烯酸钙; 瑞舒伐他汀钙RS(API); 瑞舒伐他汀钙/147-2; (3R,5S,6E)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰胺基)-5-嘧啶]-3,5-二羟基-6-庚烯酸钙; 罗素伐他汀钙; 瑞舒伐他汀钙/罗舒伐他汀钙/超级他汀钙; (+)-双{7-[4-(4-氟苯基)-6-(1-甲基乙基)-2-[甲基(甲磺酰基)氨基]-5-嘧啶基]-3R,5S-二羟基-6(E)-庚烯酸}钙; 瑞舒伐他汀钙/罗苏伐他汀钙; 瑞舒伐他汀钙 RS; 环丙氯地孕酮,环丙氯地孕酮醋酸酯; 瑞舒伐他汀-[D6]钙/精确称量; 抑制剂Rosuvastatin Calcium; (+)-(3R,5S)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基; 瑞舒伐他汀钙新工艺; 瑞舒伐他汀钙 双-[E-7-[4-(4-氟基苯基)-6-异丙基-2-[甲基(甲磺酰基)氨基]-嘧啶-5-基](3R,5S)-3,5-二羟基庚-6-烯酸]钙盐; 超级他汀钙; 瑞舒伐他汀钙盐; 舒伐他汀钙; 罗苏伐他汀钙/瑞舒伐他汀钙; 罗素伐他汀钙(瑞苏伐他汀钙,超级他汀钙); 瑞舒伐他汀系统适用性 标准品; ROSUVASTATIN CALCIUM 瑞舒伐他汀钙; 瑞苏伐他丁钙; 舒伐他汀钙威; 瑞舒伐他汀钙(原药); Rosuvastatin (ZD4522) calcium 瑞舒伐他汀钙,S2169; 瑞舒伐他汀-D3钙盐; 瑞舒伐他汀钙(ZD-4522); 罗苏伐他汀钙盐; (3R,5S,E)-7-(4-(4-氟苯基)-6-异丙基-2-(N-甲基甲磺胺基)嘧啶-5-基)-3,5-二羟基庚-6-烯酸钙(2:1); 罗舒伐他汀钙; 超级他汀钙盐; 罗苏伐他汀钙(超级他汀钙); 瑞舒伐他汀钙对照品; 瑞舒伐他汀钙,10 MM DMSO 溶液; 瑞舒伐他汀钙RSF; 瑞舒伐他汀钙 API (+)-(3R,5S)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰基氨基)嘧啶 -5-基]-3,5-二羟基-6-(E)-庚烯酸钙; 罗伐他汀钙/瑞舒伐他汀钙; 瑞舒伐他汀杂质; 瑞舒伐他汀; 瑞舒伐他汀钙溶液,100PPM; 瑞舒伐他汀钙(晶型A); 舒伐他汀钙盐; 瑞舒伐他汀钙 标准品; 罗素伐他丁钙; 瑞舒伐他丁钙; 瑞舒代他汀钙; 罗伐他汀钙; 罗素他汀钙; (3R,5S,6E)-7-[4-(4-氟苯基); 罗素伐他江钙(瑞苏伐他汀钙,超级他汀钙); 瑞舒伐他汀钙/罗苏伐他汀钙(标准品); 3-二甲基丁胺柠檬酸盐; 罗舒伐他汀; 瑞舒伐他汀钙(无定形); 瑞舒伐他汀钙盐 CRS
• 英文别名: (3R,5S,6E)-7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyht-6-enoic acid; Calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyht-6-enoate; Calcium bis[(3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate]; ROSUVASTATIN CALCIUM; (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyht-6-enoic acid, calcium salt; Rosuvastatin Calcium CRS; Rosuvastatin CaL; Rosuvastatin S-Isomer; calcium bis[(3R,5S,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate]; (E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyht-6-enoate; 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt, (3R,5S,6E)- (2:1); ROSUVASTATIN CALCIUM (ROSUVASTATIN HEMICALCIUM); Rosuvastatin Calium; (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[N-methyl(n-methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-Htenoic calcium; Calciumbis[(3R,5S,6E)-7-{4-(4-fluorphenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoat]; (+)-bis[7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3R,5S-dihydroxy-6(E)-htenoic acid]calcium salt; 7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyht-6-enoic acid; rosuvastatin Rosuvastatin CalciuM; Rosuvastatin CalciuM (AMorphous); ZD 4522, Calcium Salt; RosuvastatinCalcium>; Rosuvastatin Calcium (Y0001719); 6-Htenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E); MFCD04112702; Fortius; Rosuvastatin Calcium，Rusuvastatin Calcium; Rosuvastatin Calcium Salt CRS; Rosuvastatin Calcium (BP); Rosuvastatin (ZD4522) calcium; BD-04; calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethan-3-ylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyht-6-enoate; (3R,5R,6E)-7-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]-3,5-dihydroxyht-6-enoic acid; Crestor; Rosuvastain Calcium; Rosuvastatin CalciuM (ForM A); Rosuvastatin-d3 Calcium Salt; Rosuvastatin for system suitability (Y0001721); ZD4522; (+)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethanesulfonylaMino)pyriMidin-5-yl]-3,5-dihydroxy-6(E)-htenoic acid calciuM salt (2:1); (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[N-methyl(n-methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-H; Rosuvastatin for system suitability; RosuvastatinCalcium&Z7,Z8,R3; Rosuvastatin calcium Solution, 100ppm; ROSUVASTATIN, CALCIUM SALT; Rost; ZD 4522 Calcium; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl])-3,5-dihydroxyht-6-enoic acid hemicalcium salt; Rosuvastatin calciuM(Crestor); Rosuvastatin CalciuM (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-Methylethyl)-2-[N-Methyl(n-Methylsulfonyl)amino]-5-pyriMidinyl]-3,5-dihydroxy-6-Htenoic calciuM; Rosuvastatin Calcium (3R,5S,6E)-7-{4-(4-Fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5- dihydroxyht-6-enoic acid calcium salt; bis[(3R,5S,6E)-7-{4-(4-fluorophényl)-6-(1-méthyléthyl)-2-[méthyl(méthylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-énoate] de calcium; Rosuvastatin (Calcium); Rosuvastatin Calcium(W.S); ROSUVASTATIN CA; Calcium bis[(3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate]; (3R,5S,6E)-7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyht-6-enoic acid calcium salt; Rosuvastatin Impurity; Rosuvastatin for system suitability CRS; Calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-y; Rosuvastatin calciumQ: What is Rosuvastatin calcium Q: What is the CAS Number of Rosuvastatin calcium Q: What is the storage condition of Rosuvastatin calcium Q: What e the applications of Rosuvastatin calcium; Rosuvastatin hemicalcium; Rosuvastatin (as Ca salt); (+/-)-Fgesin; Rosuvastatin calcium //BP; Rosuvastadine

物化性质

• 沸点: 745.6ºC at 760 mmHg
• 熔点: 122ºC
• 分子式: C₄₄H₅₄CaF₂N₆O₁₂S₂
• 分子量: 1001.1
• 闪点: 404.7ºC
• 精确质量: 1000.2835107
• PSA: 304.26000
• LogP: 4.29560
• 外观性状: 白色至灰白色结晶固体
• 储存条件: -20°C Freezer

生物活性

• 描述: Rosuvastatin钙盐是HMG-CoA还原酶抑制剂,IC50为11 nM。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.

  [2]. Kim, Y.S., et al., Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. J Cardiovasc Pharmacol, 2007. 49(6): p. 376-83.

  [3]. Carswell, C.I., G.L. Plosker, and B. Jarvis, Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.

  [4]. Stalker, T.J., A.M. Lefer, and R. Scalia, A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol, 2001. 133(3): p. 406-12.

  [5]. Schneck, D.W., et al., The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther, 2004. 75(5): p. 455-63.

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2935009090

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%