1026016-83-0

• 常用中文名：(+)-丁苯那嗪
• 常用英文名：(±)-Tetrabenazine
• CAS号：1026016-83-0
• 分子式：C₁₉H₂₇NO₃
• 分子量：317.423
• 相关类别： 信号通路 跨膜转运 单胺转运蛋白
• 发布时间：2018-04-19 08:00:00
• 更新时间：2026-07-15 10:15:31
• Tetrabenazine ((+)-)是一个可逆转的VMAT-2的抑制剂。

名称

• 中文名: (+)-丁苯那嗪
• 英文名: (+)-tetrabenazine
• 中文别名: (3R,11BR)-3-异丁基-9,10-二甲氧基-3,4,6,7-四氢-1H-吡啶并[2,1-A异喹啉-2(11BH)-酮; (+)-R,R-丁苯那嗪; (3R,11BR)-1,3,4,6,7,11B-六氢-9,10-二甲氧基-3-异丁基-2H-苯并[A]喹嗪-2-酮; (+)-四苯那嗪; (+)-丁苯那嗪,10 MM DMSO 溶液; 抑制剂Tetrabenazine (+)
• 英文别名: (+) Tetrabenazine,(+)Tetrabenazine; (3R,11bR)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one; 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one; Tetrabenazine ((+)-); 11bR)-Tetrabenazine; (+)-TBZ; (3R,11bR)-9,10-dimethoxy-3-(propan-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one; (3R,11bR)-Tetrabenazine; (+)-Tetrabenazine; (3R,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one; 11bR)-TBZ; (3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one; tetrabenazine; 2-Oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine; 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-di; (3R,11bR)-TBZ; (+)-Tetrabenazine (TBZ); (+)-Tetrabenazine, 10 mM in DMSO; 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR); (3R,11bR)-3-Isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one; (3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one; (+)-TETRABENAZINE;(+)-TBZ;(3R;11BR)-TBZ;(3R;11BR)-TETRABENAZINE; 9,10-Dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isochinolin-2-on; (3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one; 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 448.9±45.0 °C at 760 mmHg
• 分子式: C₁₉H₂₇NO₃
• 分子量: 317.423
• 闪点: 225.3±28.7 °C
• 精确质量: 317.199097
• PSA: 38.77000
• LogP: 3.48
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.554
• 储存条件: 室温，保存在惰性气体中

生物活性

• 描述: Tetrabenazine ((+)-)是一个可逆转的VMAT-2的抑制剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 单胺转运蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Podurgiel SJ et al. The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine. Behav Brain Res. 2016 Feb 1;298(Pt B):188-91.

  [2]. Peter D et al. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J Biol Chem. 1996 Feb 9;271(6):2979-86.