(+)-丁苯那嗪

• 常用名: (+)-丁苯那嗪
• 英文名: (±)-Tetrabenazine
• CAS号: 1026016-83-0
• 分子量: 317.423
• 密度: 1.1±0.1 g/cm3
• 沸点: 448.9±45.0 °C at 760 mmHg
• 分子式: C₁₉H₂₇NO₃
• 熔点: N/A
• 闪点: 225.3±28.7 °C

(+)-丁苯那嗪用途

Tetrabenazine ((+)-)是一个可逆转的VMAT-2的抑制剂。

(+)-丁苯那嗪名称

• 中文名: (+)-丁苯那嗪
• 英文名: (+)-tetrabenazine

(+)-丁苯那嗪生物活性

• 描述: Tetrabenazine ((+)-)是一个可逆转的VMAT-2的抑制剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 单胺转运蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Podurgiel SJ et al. The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine. Behav Brain Res. 2016 Feb 1;298(Pt B):188-91.

  [2]. Peter D et al. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J Biol Chem. 1996 Feb 9;271(6):2979-86.

(+)-丁苯那嗪物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 448.9±45.0 °C at 760 mmHg
• 分子式: C₁₉H₂₇NO₃
• 分子量: 317.423
• 闪点: 225.3±28.7 °C
• 精确质量: 317.199097
• PSA: 38.77000
• LogP: 3.48
• InChIKey: MKJIEFSOBYUXJB-GDBMZVCRSA-N
• SMILES: COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.554
• 储存条件: 室温，保存在惰性气体中

(+)-丁苯那嗪靶点实验

查看更多实验

实验名称：Competition of compound for the in vivo localization of [11C] Methoxytetrabenazine in... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL737514

实验名称：Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid... 来源：ChEMBL 靶标：Synaptic vesicular amine transporter External Id：CHEMBL1772769

实验名称：Competition of compound for the in vivo localization of [11C] Methoxytetrabenazine in... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL748348

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(+)-丁苯那嗪英文别名

• (3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
• (3R,11bR)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
• tetrabenazine
• 2-Oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine
• 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
• 9,10-Dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isochinolin-2-on
• (3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
• 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
• Tetrabenazine ((+)-)