289042-12-2

• 常用中文名：6-[(1E)-2-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]-5-嘧啶]乙烯基]-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯
• 常用英文名：tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
• CAS号：289042-12-2
• 分子式：C₂₉H₄₀FN₃O₆S
• 分子量：577.7
• 发布时间：2018-03-18 08:00:00
• 更新时间：2026-07-02 19:39:19

名称

• 中文名: 6-[(1E)-2-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]-5-嘧啶]乙烯基]-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯
• 英文名: tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
• 中文别名: 瑞舒伐他汀钙中间体; 瑞舒伐他汀钙-ZF; (4R,6S)-6-[(1E)-2-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]-5-嘧啶]乙烯基]-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯; 6-[(1E)-2-[4-(4- 氟苯基 )-6- 异丙基 -2-[ 甲基 ( 甲磺酰 ) 氨基 ]-5- 嘧啶 ] 乙烯基 ]-2,2- 二甲基 -1,3- 二氧六环 -4- 乙酸叔丁酯(R1); 6-[(1E)-2-[4-(4-氟苯基)-6-异丙基-1-[甲基(甲磺酰基)氨基]-2-嘧啶基]乙烯基]-5,2-二甲基-2,1-二氧六环-3-乙酸叔丁酯; 瑞舒伐他汀钙 ( ROSUVASTATIN CA); 罗素伐他汀钙中间体 R-2; 6-[(1E)-2-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]-5-嘧啶]乙烯基]; 罗苏伐他汀杂质F; 瑞舒伐他汀杂质F-F,-C); 瑞舒伐他汀钙 D7,6-[(1E)-2-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]-5-嘧啶]乙烯基]-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯; 瑞舒伐他汀钙杂质F; 瑞舒伐他汀相关化合物C; 瑞舒伐他汀钙R-1; 瑞舒伐他汀钙中间体R1; 舒伐他汀杂质BEM; 瑞舒伐他汀缩丙酮叔丁基酯; 6-[(1E)-2-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]-5-嘧啶]乙烯基]-(4R-CIS)-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯; 6-[(1E)-2-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]-5-嘧啶]乙烯基]-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯(瑞舒伐他汀钙中间体); 瑞舒伐他汀对接物; 7 R-2 6-[(E)-2-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]-5-嘧啶]乙烯基]-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯; 叔丁基 2-((4R,6S)-6-((E)-2-(4-(4-氟苯基)-6-异丙基-2-(N-甲基甲基磺酰胺基)嘧啶-5-基)乙烯基)-2,2-二甲基-1,3-二噁烷-4-基)乙酸酯; 2-((4R,6S)-6-((E)-2-(4-(4-氟苯基)-6-异丙基-2-(N-甲基甲基磺酰胺基)嘧啶-5-基)乙烯基)-2,2-二甲基-1,3-二恶烷-4-基)乙酸叔丁酯; 瑞舒伐他汀钙F; 瑞舒伐他汀缩合叔丁酯; 瑞舒伐他汀钙R1中间体; 杂质F; 2-((4R,6S)-6-((E)-2-(4-(4-氟苯基)-6-异丙基-2-(N-甲基甲基磺酰胺基)嘧啶-5-基)乙烯基)-2,2-二甲基-1,3-二噁烷-4-基)乙酸叔丁酯; 6-[(1E)-2-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]-5-嘧啶]乙烯基]-2,2-二甲基-1; 瑞舒伐他汀缩合叔丁酯(R1); 瑞舒伐他汀杂质28(瑞舒伐他汀杂质F); 瑞舒伐他汀杂质F; 瑞舒伐他汀钙-7; 瑞舒伐他汀钙中间体6-[2-[4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰基氨基)嘧啶-5-基]-乙烯基]-(4R,6S)-2,2-二甲基-[1,3]二恶烷-4-基)-乙酸叔丁酯(R1); 罗苏伐他汀的醋酸叔丁酯
• 英文别名: Rosuvastatin intermediate R-2; Rosuvastatin intermediate R-1; 6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester; tert-Butyl 6-[(1E)-2; Rosuvastatin Acetonide; 6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1 -methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester; Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-(n-methyl,n-methyl sulphonyl amino) pyrimidine-5-yl]-(3r-5s)-dioxane-(e)-6 htane; Rosuvastatin Impurity F (Rosuvastatin Acetonide t-Butyl Ester); 1,3-Dioxane-4-acetic acid,6- (1E)-2- 4-(4-fluorophenyl)-6-(1-Methylethyl)-2- Methyl(Methylsulfonyl)amino -5-pyriMidinyl ethenyl -2,2-diMethyl-, 1,1-diMethylethyl ester, (4R,6S); 1,1-Dimethylethyl(4R,6S)-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate; R-2：Tert-butyl –(+)7-[4-(4-fluorophenyl)-6-lsopropyl -2-(N-methylsulfonylamino)-pyrlmidine-5-yl]-(3R,5S)- dioxane-(E)-6-htenate; 2-Methyl-2-propanyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate; R-1: Tert-Butyl6-[(1E)-2-[4-(4- fluorophenyl)-6-(1-methylethyl)-2- [methyl(methylsulfonyl) amino]-5- pyrimidinyl]ethenyl]-2,2-dimethyl-1,3- dioxane-4-acetate; Rosuvastatin calcium-7; tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2- (N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl- 1,3-dioxan-4-yl)aceta; (ZD-8-1) tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-Methylethyl)-2-[Methyl(Methylsulfonyl)amino]-5-pyriMidinyl]ethenyl]-2,2-diMethyl-1,3-dioxane-4-acetate; t-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate; tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate [R1]; 1,3-Dioxane-4-acetic acid, 6-[(E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester; Rosuvastatin Acetonide t-Butyl Ester; tert-Butyl {6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate; Tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-flurophenyl)-6-isopropyl-2-(N- methylmethane sulfonamidoPyrimidin - 5-yl)vinyl)-2,2-dimethyl-1,3-dioxane-4-yl-)acetate (TIN); Rosuvastatin Calcium Impurity F; 2-Methyl-2-propanyl {6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate; ERT-BUTYL-(+)7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL-N-METHYL SULFONYLAMINO)PYRIMIDINE-5-YL] -(3R,5S)-DIOXANE-(E); Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-yl]-(3R,5S)-dioxane-(E); Rosuvastatin Impurity 28; 3-Dioxane-4-acetic acid,6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-Methylethyl)-2-[Methyl(Methylsulfonyl)amino]-5-pyriMidinyl]ethenyl]-2,2-diMethyl-, 1,1-diMethylethyl ester, (4R,6S); tert-Butyl rosuvastatin; R1 ROSUVASTATIN; tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonaMido)pyriMidin-5-yl)vinyl)-2,2-diMethyl-1,3-dioxan-4-yl)acetate; Rosuvastatin Impurity 28(Rosuvastatin Impurity F); Rosuvastatin Acetonide tertButyl Ester; Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-( N-METHYL- N-MethylsulfonylaMino)pyriMidine-5-yl]-(3R,5S)-dioxane-(E)-6-htenate; (4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester; tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2; MFCD08458343; ethyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate; Rosuvastatin R1; 6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dime; Rosuvastatin Related Compound C; R-1 interMediate; Tert-butyl –(+)7-[4-(4-fluorophenyl)-6-lsopropyl -2-(N-methylsulfonylamino)-pyrlmidine-5-yl]-(3R,5S)- dioxane-(E)-6-htenate; Tert-Butyl-(+)7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methyl Sulfonylamino)Pyrimidine-5-Yl]-(3r,5s)-Dioxane-(E)-6-Htena; (4R,6S)-6-[(1E)-2-[4-(4-FLUOROPHENYL)-6-(1-METHYLETHYL)-2-[METHYL(METHYLSULFONYL)AMINO]-5-PYRIMIDINYL]ETHENYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID, 1,1-DIMETHYLETHYL ESTER; Rosuvastatin calciuM interMediate R-2; 6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2; tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxa; RSV Intermediate; R-1: TERTIY-BUTYL-(+)-[(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL, N-METHYL SULPHONYL AMINO) PYRIMIDINE-5-YL]-(3R-5S)-DIOXANE-(E)-6 HTANE; High quality ISO & BV Factory Tert-but; 1,1-dimethylethyl [(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)a; tert-Butyl6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate; Rosuvastatin Impurity F; Rosuvastatin tert-Butyl Ester; Rosuvastatin BEM; 2-{6-[(E)-2-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]ethenyl]-2,2-diMethyl-1,3-dioxan-4-yl}-3,3-diMethylbutanoate; tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetat; (4R,6S,1E)-tert-Butyl 6-[2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate; (4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid; tert-butyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate; Tert-butyl-2-((4R,6S)-6-(E)-2-(4-(4-fluorophenyl)-6-Isopropyl-2-(N-methyl-D3-Methylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-Dimethyl-1,3-dioxan-4-yl)acetate; tert-Butyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate; Tertbutyl (E)-(6-{2-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methyl sulfonyl)amino pyrimidin-5-yl]vinyl}(4R,5R)-2,2-dimethyl[1,3]dioxane-4-yl)acetate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 704.2±70.0 °C at 760 mmHg
• 熔点: 153-155°C
• 分子式: C₂₉H₄₀FN₃O₆S
• 分子量: 577.7
• 闪点: 379.7±35.7 °C
• 精确质量: 577.26218534
• PSA: 116.30000
• LogP: 2.24
• 外观性状: 白色或灰白色粉末
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.564
• 储存条件: Refrigerator

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