289042-10-0

• 常用中文名：瑞舒伐他汀中间体Z-8.1
• 常用英文名：Methanesulfonamide,N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl
• CAS号：289042-10-0
• 分子式：C₂₈H₂₉FN₃O₃PS
• 分子量：537.585
• 发布时间：2018-08-09 12:07:34
• 更新时间：2026-07-01 18:21:27

名称

• 中文名: N-[5-(联苯-膦酰基甲基)-4-(4-氟-苯基)-6-异丙基-嘧啶-2-基]-N-甲基-甲烷磺胺
• 英文名: N-[5-(diphenylphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
• 中文别名: N-[5-(联苯-膦酰基甲基)-4-(4-氟-苯基)-6-异丙基-嘧啶-2-基]-N-甲基-甲烷磺胺(Z8); 瑞舒伐他汀钙中间体; N-(5-((二苯基磷酰基)甲基)-4-(4-氟苯基)-6-异丙基嘧啶-2-基)-N-甲基甲磺酰胺(瑞舒伐他汀杂质); 4-(4-氟苯基)-5-二苯基氧磷-6-异丙基-2-[(N-甲基-N-甲磺酰胺基)]-嘧啶 (Z8.1); 天; 4-(4-氟苯基)-5-(二苯基氧磷)甲基-6-异丙基-2-[ (N-甲基-N-甲磺酰基氨基) ]嘧啶; N-[5-( 二苯基膦酰甲基 )-4-(4- 氟苯基 )-6- 异丙基嘧啶 -2- 基 ]-N- 甲基甲磺酰胺 (Z8.3); N-[5-(联苯-膦酰基甲基)-4-(4-氟-苯基)-6-异丙基-嘧啶-2-基]-N-甲基-甲烷磺胺(Z8.3); N-[5-(联苯·磷酰基甲基)-4-(4氟-苯基)-6-异丙基-嘧啶-2-基]N-甲基-甲烷磺胺; N-[5-(二苯基膦酰甲基)-4-(4-氟苯基)-6-异丙基嘧啶-2-基]-N-甲基甲磺酰胺; 瑞舒伐他汀杂质55; 瑞舒伐他汀钙Z-8.1; 罗苏伐他汀 中间体ZD-9; N-[4-(4-氟苯基)-5-(二苯基氧膦基)甲基-6-异丙基-2-嘧啶基]-N-甲基甲磺酰胺基; 4-(4-氟苯基)-5-二苯基氧磷-6-异丙基-2-[(N-甲基-N-甲磺酰胺基)]-嘧啶; 瑞舒伐他汀钙中间体Z8.1; 4-(4-氟苯基)-5-三苯基磷溴-6-异丙基-2-[(N-甲基-N-甲磺酰胺基)]-嘧啶
• 英文别名: N-{5-[(Diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl}-N-methylmethanesulfonamide; diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl]phosphine oxide; diphenyl [4-(4-fluoropheny)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-ylmethyl] phosphine oxide; diphenyl[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-ylmethyl]phosphine oxide; N-(5-((Diphenylphosphoryl); N-{5-[(Diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl}-N-methylmethanesulfonamide; N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethan; N-(5-((Diphenylphosphoryl)Methyl)-4-(4-fluorophenyl)-6-isopropylpyriMidin-2-yl)-N-MethylMethanesulfonaMide; Methanesulfonamide, N-[5-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl; 4-(4-fluorophenyl)-6-isopropyl-2-[(n-methyl-n-methylsulfonyl)amino] pyriminl-5-yl- phosphine oxide; Rosuvastatin Intermediates ZD9; 4-(4-Fluorophenyl)-5-(diphenylphosphinyl)methyl-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine; N-[5-[(Diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethan; N-[5-[(diphenylphosphinoyl)-methyl]-4-(4-fluorophenyl)-6-isopropyl-pyrimidindin-2-yl]-N-methyl-methanesulfonamide; Rosuvastatin Diphenylphosphine Oxide; Diphenyl [4-(4-fluorophenyl)- 6-isopropyl-2-[(n-Methyl- n-ethylsulfonyl)amino] pyriMidine-5-yl- ethyl]phosphine; 4-(4-fluorophenyl); Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-[(2-n-Methyl-n-Methylsulfonyl)amino]pyriMidine-5-yl-Methyl]phosphine oxide; Triphenyl[4-(4-fluorophenyl)-6-isopropyl-2-[(2-n-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methyl]phosphine bromine; N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesu; Diphenyl[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonyl)amino-pyrimidin-5-yl-methyl]phosph; Z-8: DIPHENYL [4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[(N-METHYL-N-METHYLSULFONYL) AMINO] PYRIMIDINE-5-YL-METHYL] PHOSPHINE OXIDE; N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide(Z8.3); N-{5-[(Diphenylphosphoryl)methyl]-4-(4-fluorphenyl)-6-(propan-2-yl)pyrimidin-2-yl}-N-methylmethansulfonamid; AC-3407; Rosuvastatin InterMediate Z-8.1; N-[5-(Diphenyl-phosphinoylmethyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide; rosuvastatin intermediates Z-8.1; N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide; N-[5-[(Diphenylphosphinyl)Methyl]-4-(4-fluorophenyl)-6-(1-Methylethyl)-2-pyriMidinyl]-N-MethylMethanesulfonaMide; N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfon; N-[5-(diphenyl-phosphinoylmethyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide; Diphenyl[4-(4-Fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonyl)amino-pyriMidin-5-yl-Methyl]phosphine Oxide; N-{5-[(diphenylphosphoryl)methyl]-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl}-N-methylmethanesulfonamide; N-[5-(Diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]; 6-isopropylpyrimidin-2-yl); N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (Rosuvastatin Impurity)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 679.1±65.0 °C at 760 mmHg
• 分子式: C₂₈H₂₉FN₃O₃PS
• 分子量: 537.585
• 闪点: 364.5±34.3 °C
• 精确质量: 537.165100
• PSA: 98.42000
• LogP: 3.21
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.625
• 储存条件: 室温，保存在惰性气体中

合成路线

799842-07-2 719-80-2 ~71% 289042-10-0

文献：WO2004/103977 A2, ; Page 24-25 ;

289042-11-1 719-80-2 ~% 289042-10-0

文献：US2004/49036 A1, ; Page 2; 3 ;

1079-66-9 147118-36-3 ~24% 289042-10-0

文献：US6160115 A1, ;

147118-36-3 ~% 289042-10-0

文献：US6160115 A1, ;

147118-30-7 ~% 289042-10-0

文献：WO2012/2741 A2, ; WO 2012/002741 A2

925422-06-6 ~% 289042-10-0

文献：WO2012/2741 A2, ; WO 2012/002741 A2

上下游产品

上游产品  6
799842-07-2 719-80-2 289042-11-1 1079-66-9
147118-36-3 147118-30-7
下游产品  2
503610-43-3 289042-12-2