355806-00-7

• 常用中文名：瑞舒伐他汀叔丁酯
• 常用英文名：tert-Butyl rosuvastatin
• CAS号：355806-00-7
• 分子式：C₂₆H₃₆FN₃O₆S
• 分子量：537.644
• 发布时间：2018-08-09 17:53:34
• 更新时间：2024-01-02 05:27:42

名称

• 中文名: 瑞舒伐他汀叔丁酯
• 英文名: tert-Butyl rosuvastatin
• 中文别名: (6E)-7-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]嘧啶-5-基]-(3R,5S)-3,5-二羟基庚-6-烯酸叔丁酯; 8 R-3 (6E)-7-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]嘧啶-5-基]-(3R,5S)-3,5-二羟基庚-6-烯酸叔丁酯; 罗苏伐他汀的叔丁基酯; 罗素伐他汀钙中间体 R-3; 瑞舒伐他汀中间体R-2
• 英文别名: Rosuvastatin calciuM interMediate R-3; Rosuvastatin intermediate R-3; Rosuvastatin intermediate R-2; Rosuvastatin calciuM interMediate R-2; 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3R,5S,6E)-; 1,3-Dioxane-4-acetic acid, 6-[(E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester; Rosuvastatin Acetonide t-Butyl Ester; Rosuvastatin tert-Butyl Ester; tert-Butyl {6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate; 2-Methyl-2-propanyl {6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate; tert-Butyl rosuvastatin; tert-butyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate; R-1 interMediate; tert-Butyl rosuvasta; ZD-8; 2-Methyl-2-propanyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate; tert-Butyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate; Rosuvastatin t-Butyl Ester

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 704.2±70.0 °C at 760 mmHg
• 分子式: C₂₆H₃₆FN₃O₆S
• 分子量: 537.644
• 闪点: 379.7±35.7 °C
• 精确质量: 537.230896
• PSA: 138.30000
• LogP: 2.24
• 外观性状: 白色至灰白色晶体粉末
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.564
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xi
• 海关编码: 2935009090

合成路线

1007871-85-3 ~81% 355806-00-7

文献：WO2009/47577 A1, ; Page/Page column 35-36; 38-39 ;

289042-12-2 ~87% 355806-00-7

文献：WO2012/172564 A1, ; Page/Page column 22-23 ;

1235588-97-2 ~93% 355806-00-7

文献：WO2010/81861 A1, ; Page/Page column 41 ;

910867-13-9 ~% 355806-00-7

文献：WO2006/100689 A1, ; Page/Page column 15-16 ;

上下游产品

上游产品  2
289042-12-2 1007871-85-3
下游产品  2
503610-43-3 287714-41-4

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%