355806-00-7

• 常用中文名：瑞舒伐他汀叔丁酯
• 常用英文名：tert-Butyl rosuvastatin
• CAS号：355806-00-7
• 分子式：C₂₆H₃₆FN₃O₆S
• 分子量：537.644
• 发布时间：2018-08-09 17:53:34
• 更新时间：2026-07-06 10:02:32

名称

• 中文名: 瑞舒伐他汀叔丁酯
• 英文名: tert-Butyl rosuvastatin
• 中文别名: 瑞舒伐他汀钙中间体R1.5; 罗素伐他汀钙中间体 R-3; 瑞舒伐他汀钙中间体八; 瑞舒伐他汀酸叔丁酯; (3R,5S,6E)-7-[4-(4-氟苯基)-6-异丙基-2-[(甲磺酰基)甲基氨基]嘧啶-5-基]-3,5-二羟基庚-6-烯酸叔丁酯; 瑞舒伐他汀杂质20(叔丁基瑞舒伐他汀); (3R,5S,6E)-7-(4-(4-氟苯基)-6-异丙基-2-(甲磺酰基)甲胺基]嘧啶-5-基)-3,5-二羟基庚-6-烯酸叔丁酯; 瑞舒伐他汀钙标准品R5S; 8 R-3 (6E)-7-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]嘧啶-5-基]-(3R,5S)-3,5-二羟基庚-6-烯酸叔丁酯; 丁基7-[4-(4-氟苯基)-6-异-2-(N-甲基-N-甲基磺酰氨基)嘧啶-5-基-(3的,55)-二羟基-(E)-6-庚烯酸甲酯; 瑞舒伐他汀钙 R1,(6E)-7-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰氨基)嘧啶-5-基]-(3R,5S)-3,5-二羟基庚-6-烯酸叔丁酯; 瑞舒伐他汀碱水解未完全产物; 瑞舒伐他汀钙R-2; 瑞舒伐他汀钙中间体R-2; (6E)-7-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]嘧啶-5-基]-(3R,5S)-3,5-二羟基庚-6-烯酸叔丁酯 (R-2); 瑞舒伐他汀钙杂质10; 化合物 (3R,5S,6E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[(METHANESULFONYL) METHYLAMINO]PYRIMIDIN-5-YL]-3,5-DIHYDROXYHT-6-ENOIC ACID TERT-BUTYL ESTER; 瑞舒伐他汀钙标准品001; (6E)-7-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]嘧啶-5-基]-(3R,5S)-3,5-二羟基庚-6-烯酸叔丁酯; 罗苏伐他汀的叔丁基酯; 瑞舒伐他汀酸叔丁基酯; 瑞舒伐他汀杂质42; 瑞舒伐他汀杂质22; (6E)-7-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰基)氨基]嘧啶-5-基]-(3R,5S)-3,5-二羟基庚-6-烯酸叔丁酯; 瑞舒伐他汀中间体R-2; 罗苏伐他汀酸叔丁基酯
• 英文别名: R1.5; T-BUTYL 7-[4-(4-FLUOROPHENYL)-6-ISO-PROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDIN-5-YL] -(3R,5S)-DIHYDROXY-(E)-6-HTENATE; Rosuvastatin intermediate R-3; Rosuvastatin intermediate R-2; Rosuvastatin tert-butyl; ert-Butyosuvastatin; tert-Butyl rosuvastatin,(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl amino)pyrinidine-5-yl]-3,5-dihydrosy-6-htane acid,Methyl ester; Rosuvastatin Impurity 7/Rosuvastatin tert-Butyl Ester/(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]-pyrimidin-5-yl]-3,5-dihydroxyht-6-enoic acid tert-butyl ester; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]pyrimidin-5-yl]-3,5-dihydroxyht-6-enoic acid tert-butyl ester; tert-butyl rosuvastatin; Rosuvastatin Acid t-Butyl Ester; tert-Butyl Rosuvastatin (Rosuvastatin IMpurity); tert-Butyl(+)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methanesul fonylamino)pyrimidin-5-yl]-3,5-Dihydroxy-6(E)-Htenoate; dihydroxyht-6-enoate; (E) - (3R,5S)-7-{4-(4-FLUOROPHENYL)-6-ISOPROPYL-2{METHYL SULPHONYLAMINO)] PYRIMIDIN-5-YL}-3,5-DIHYDROXYHTENOICACID; R-1.5: (+)-(3R, 5S), TERT-BUTYL 7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL-N-METHYLSULPHONYLAMINO)-PYRIMIDINE-5-YL]-3, 5-DIHYDROXY-6(E)-HTENATE; 2-Methyl-2-propanyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate; Rosuvastatin t-Butyl Ester; Rosuvatatin Impurity 22; Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-yl]-(3R,5S)-dihydroxy; Rosuvastatin calcium-11; (+)-(3r,5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2; tert-Butyl Rosuvastatir; 1,3-Dioxane-4-acetic acid, 6-[(E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester; Rosuvastatin Acetonide t-Butyl Ester; Rosuvastatin Impurity 77; tert-butyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyht-6-enoate; tert-Butyl {6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate; 2-Methyl-2-propanyl {6-[(E)-2-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate; tert-Butyl rosuvasta; Rosuvatatin Tertiybutyl Ester; Rosuvastatin calcium-001; (6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyht-6-enoicacidtert-butylester; tert-Butyl (6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroxyht-6-enoate; Rosuvastatin calcium-001-3R5S; Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methylsulfonylamino)pyrimidine-5-yl] -(3R,5S) -dihydroxy -(E)-6-Htena; (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-Methylethyl)]-2-[Methyl(Methylsulfonyl)amino-5-pyriMidinyl]-3,5-dihydroxy-6-htenoicacidtert-butylester; tert-butyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N- methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyht- 6-enoate; tert-Butyl (6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5- dihydroxyht-6-enoate(R2); Rosuvastatin calcium impurity 10; Rivastatin tert-butyl ester; Rosuvastatin Impurity 20 (tert-Butyl Rosuvastatin); 7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-ht-6-enoic acid t-butyl ester; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyht-6-enoic acid tert-butyl ester; R-1 interMediate; (+)-(3R, 5S)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL-N-METHANESULFONYLAMINO)PYRIMIDIN-5-YL]-(3, 5)-DIHYDROXY-6(E)-HTENOATE; Rosuvastatin calciuM interMediate R-3; 6-Htenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3R,5S,6E); Rosuvastatin calciuM interMediate R-2; (+)-(3r,5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulphonylamino)-Pyrimidin-5-Yl]-3,5-Dihydroxy-6(E)-Htenate (R1.5 Or T-Butyl-Rosuvastatin); (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methylsulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyht-6-enoicacidtert-butylester; Rosuvastatin Impurity 10; Rosuvastatin tert-Butyl Ester; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2 [(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5 dihydroxyht -6-enoic acid tert-butyl ester or (Tert Butyl Rosuvastatin); (+)-(3r, 5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulphonylamino)-Pyrimidin-5-Yl]-3,5-Dihydroxy-6(E)-Htenate (R1.5 Or T-Butyl-Rosuvastatin); Rosuvastatin tert-butyl ester; tert-butyl (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate; (3R,5S,6E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[(METHANESULFONYL) METHYL AMINO]PYRIMIDIN-5-YL; ZD-8; tert-Butyl (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate; (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[(methanesulfonyl) methylamino]-pyrimidin-5-yl]-3

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 704.2±70.0 °C at 760 mmHg
• 分子式: C₂₆H₃₆FN₃O₆S
• 分子量: 537.644
• 闪点: 379.7±35.7 °C
• 精确质量: 537.230896
• PSA: 138.30000
• LogP: 2.24
• 外观性状: 白色至灰白色晶体粉末
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.564
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xi
• 海关编码: 2935009090

合成路线

1007871-85-3 ~81% 355806-00-7

文献：WO2009/47577 A1, ; Page/Page column 35-36; 38-39 ;

289042-12-2 ~87% 355806-00-7

文献：WO2012/172564 A1, ; Page/Page column 22-23 ;

1235588-97-2 ~93% 355806-00-7

文献：WO2010/81861 A1, ; Page/Page column 41 ;

910867-13-9 ~% 355806-00-7

文献：WO2006/100689 A1, ; Page/Page column 15-16 ;

上下游产品

上游产品  2
289042-12-2 1007871-85-3
下游产品  2
503610-43-3 287714-41-4

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%