53696-74-5

• 常用中文名：亮菌甲素
• 常用英文名：Armillarisin A
• CAS号：53696-74-5
• 分子式：C₁₂H₁₀O₅
• 分子量：234.205
• 相关类别： 原料药 消化系统用药 利胆药
• 发布时间：2018-03-09 08:00:00
• 更新时间：2026-06-30 22:47:42
• Armillarisin A 有用于溃疡性结肠炎 (UC) 研究的潜力。Armillarisin A 可上调 IL-4、下调IL-1β 的作用。

名称

• 中文名: 亮菌甲素
• 英文名: 3-Acetyl-7-hydroxy-5-(hydroxymethyl)-2H-chromen-2-one
• 中文别名: 亮菌甲素(标准品); 3-乙酰基-7-羟基-5-(羟甲基)-2H-苯并吡喃-2-酮; 天麻蜜环菌粉; 假密环菌甲素; 密环菌素; 亮菌甲素,10 MM DMSO 溶液; 假密环菌甲素对照品; millisin A #天然产物 HY-108013; 假密环菌素A; 天麻密环菌粉; 假密环菌甲素标准品; 亮菌甲素, 假蜜环菌甲素, 假蜜环菌素A; 假密环菌甲素A; 蜜环菌素A; 亮菌甲素(假蜜环菌甲素); 密环菌粉; 假蜜环菌甲素; 3-乙酰基-5-羟甲基-7-羟基香豆素
• 英文别名: millisin A, 10 mM in DMSO; millisin A //BP; MILLISINUM A; Bright bacteria mour; millisin A,michromone,millis-inum A; millisin; 2H-1-Benzopyran-2-one,3-acetyl-7-hydroxy-5-(hydroxyMethyl); 3-ACETYL-5-HYDROXYLMETHYL-7-HYDROXYCOUMIN; 3-acetyl-7-hydroxy-5-(hydroxymethyl)-2h-1-benzopyran-2-one; amillia mellea powder; millia powder; MILLISIN A; 3-Acetyl-5-hydroxylmethyl-7-hydroxycoumarin; llisin A; MFCD01662561; 3-acetyl-7-hydroxy-5-(hydroxymethyl)chromen-2-one; 3-acetyl-5-hydroxylmetyl-7-hydroxycoumin; 3-acetyl-7-hydroxy-5-(hydroxymethyl)-2h-1-benzopyran-2-on; millisinum; 3-acetyl-7-hydroxy-5-(hydroxymethyl)-1-benzopyran-2-one; 3-Acetyl-7-hydroxy-5-(hydroxymethyl); 3-Acetyl-7-hydroxy-5-(hydroxyMethyl)-2H-chroMen-2-one; 3-acetyl-5-hydroxymethyl-7-hydroxycoumin

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 565.0±50.0 °C at 760 mmHg
• 熔点: 250-255ºC
• 分子式: C₁₂H₁₀O₅
• 分子量: 234.205
• 闪点: 227.2±23.6 °C
• 精确质量: 234.052826
• PSA: 87.74000
• LogP: 0.13
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.642
• 储存条件: 2-8°C， 密封， 干燥， 惰性气体

生物活性

• 描述: Armillarisin A 有用于溃疡性结肠炎 (UC) 研究的潜力。Armillarisin A 可上调 IL-4、下调IL-1β 的作用。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Ping Wu, et al. The Effects of Armillarisin A on Serum IL-1β and IL-4 and in Treating Ulcerative Colitis. Cell Biochem Biophys. 2015 May;72(1):103-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DJ2976500 CHEMICAL NAME : 2H-1-Benzopyran-2-one, 3-acetyl-7-hydroxy-5-(hydroxymethyl)- CAS REGISTRY NUMBER : 53696-74-5 LAST UPDATED : 199707 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C12-H10-O5 MOLECULAR WEIGHT : 234.22 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 16,401,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 980 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 16,401,1981

安全

• 海关编码: 2932209090

制备

【方法一】
斜面孢子[摇瓶培养]→[25-26℃, 15-20d]一级摇瓶种子[摇瓶培养]→[25-26℃， 5-6d]二级摇瓶种子[种子罐培养，适量通气]→[26-28℃, 5-6d]一级种子培养液[种子罐培养]→[26-28℃，5-6d]二级种子培养液[发酵，适量通气]→[26-27℃，7-9d]发酵液→菌丝体经干燥， 滤液经浓缩干燥合并[烘干，磨粉]→密环菌粉。

海关

海关编码	2932209090
中文概述	2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%