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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：N,N-二甲基-10,11-二氢-3-氯-5H-二苯并[b,f]氮杂卓-5-丙胺
纯度：99.36%
规格：
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联系电话：13311869306

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]氯米帕明,97%
纯度：97.0%
规格：100mg/250mg
联系人：夏言
联系电话：18016376636

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303-49-1生产厂家

303-49-1

303-49-1结构式

常用中文名：氯米帕明
常用英文名：Clomipramine
CAS号：303-49-1
分子式：C₁₉H₂₃ClN₂
分子量：314.852
相关类别：原料药神经系统用药抗抑郁、躁狂药
发布时间：2018-08-19 18:41:16
更新时间：2024-01-03 21:50:50
氯米帕明(氯米帕明)是一种有效的5-HT再摄取阻断剂,IC50值为1.5nM。氯丙咪嗪是一种三环抗抑郁药,可用于抑郁症和强迫症(OCD)的研究[1]。

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中文名	氯米帕明
英文名	clomipramine
中文别名	氯丙咪嗪 N,N-二甲基-10,11-二氢-3-氯-5H-二苯并[b,f]氮杂卓-5-丙胺
英文别名	3-Chloroimipramine Chlorimipramine 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine 5H-Dibenz(b,f)azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl- 5H-Dibenz[b,f]azepine-5-propanamine, 3-chloro-10,11-dihydro-N,N-dimethyl- MFCD00069234 Clomipramine 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine 5-(g-Dimethylaminopropyl)-3-chloroiminodibenzyl 3-Chloro-10,11-dihydro-5-(3-dimethylaminopropyl)-5H-dibenz[b,f]azepine 3-chloro-10,11-dihydro-N,N-dimethyl-5H-Dibenz(b,f)azepine-5-propanamine Hydiphen Clomipramina 10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-5H-dibenz(b,f)azepine 3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine 3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine Monochlorimipramine ANAFRANIL 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine chloripramine EINECS 206-144-2 Chlomipramine Anafranil base

描述	氯米帕明(氯米帕明)是一种有效的5-HT再摄取阻断剂,IC50值为1.5nM。氯丙咪嗪是一种三环抗抑郁药,可用于抑郁症和强迫症(OCD)的研究[1]。
相关类别	研究领域 >> 神经疾病信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白
体外研究	氯丙咪嗪可以抑制去甲肾上腺素和5-HT的再摄取,尽管氯丙咪嗪对5-HT再摄取的抑制比对去甲肾上腺素再摄取的抑制更强烈[1]。抗抑郁药氯丙咪嗪以浓度依赖性方式抑制毒液乙酰胆碱酯酶和人血清BChE,但对大鼠脑纹状体的乙酰胆碱酯酶没有影响[2]。氯丙咪嗪干扰自噬通量,严重损害细胞毒性应激下致瘤细胞的生存能力[3]。氯丙咪嗪减少神经元原代培养中的自噬。氯丙咪嗪(1和5 µM)负性调节原代培养细胞中的神经元自噬途径[3]。Western Blot分析[3]细胞系：初级皮质神经元浓度：1和5 µM培养时间：12、24和48 小时结果：在所有分析的时间点,以浓度依赖的方式增强了LC3-I向LC3-II的转化。
体内研究	氯丙咪嗪(5-20mg/kg；腹腔注射)可引起小鼠显著的高血糖。氯丙咪嗪通过阻断5-HT2B和/或5-HT2C受体诱导小鼠高血糖,从而促进肾上腺素释放。在小鼠中,氯丙咪嗪在强迫游泳试验中减少了不动,这是抗抑郁药的行为模型。氯丙咪嗪还抑制强迫症动物模型,即小鼠的大理石掩埋行为[1]。氯丙咪嗪(20 mg/kg)降低小鼠组织中的自噬通量[3]。动物模型：C57BL/6 J小鼠(6周龄,22-25岁) g) [3]剂量：20 mg/kg给药：腹腔注射21天结果：氯丙咪嗪治疗小鼠的肝脏LC3-II和p62均显著高于溶媒治疗小鼠。
参考文献	[1]. Yumi Sugimoto, et al. The tricyclic antidepressant Clomipramine increases plasma glucose levels of mice. J Pharmacol Sci. 2003 Sep;93(1):74-9. [2]. Mushtaq Ahmed, et al. Comparative study of the inhibitory effect of antidepressants on cholinesterase activity in Bungarus sindanus (krait) venom, human serum and rat striatum. J Enzyme Inhib Med Chem. 2008 Dec;23(6):912-7. [3]. Federica Cavaliere,The tricyclic antidepressant Clomipramine inhibits neuronal autophagic flux. Sci Rep. 2019 Mar 19;9(1):4881.

密度	1.1±0.1 g/cm3
沸点	434.2±45.0 °C at 760 mmHg
分子式	C₁₉H₂₃ClN₂
分子量	314.852
闪点	216.4±28.7 °C
精确质量	314.154968
PSA	6.48000
LogP	5.39
外观性状	白色至灰白色粉末
蒸汽压	0.0±1.0 mmHg at 25°C
折射率	1.582
储存条件	库房通风低温干燥,与食品原料分开存放
水溶解性	H2O: 25 mg/mL
分子结构	1、摩尔折射率：93.81 2、摩尔体积（m³/mol）：281.1 3、等张比容（90.2K）：714.6 4、表面张力（dyne/cm）：41.7 5、极化率（10 ^-24cm ³）：37.19
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:2 4.可旋转化学键数量:4 5.互变异构体数量:无 6.拓扑分子极性表面积6.5 7.重原子数量:22 8.表面电荷:0 9.复杂度:346 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	一、物性数据性状：白色或类白色粉末密度（g/mL,25/4℃）：不可用相对蒸汽密度（g/mL,空气=1）：不可用熔点（ºC）：不可用沸点（ºC,常压）：不可用沸点（ºC,5.2kPa）：不可用折射率：不可用闪点（ºC）：不可用比旋光度（º）：不可用自燃点或引燃温度（ºC）：不可用蒸气压（kPa,25ºC）：不可用饱和蒸气压（kPa,60ºC）：不可用燃烧热（KJ/mol）：不可用临界温度（ºC）：不可用临界压力（KPa）：不可用油水（辛醇/水）分配系数的对数值：不可用爆炸上限（%,V/V）：不可用爆炸下限（%,V/V）：不可用溶解性：溶于水

毒理学数据:

二、毒理学数据：

急性毒性：不可用。

生态学数据:

三、生态学数据：

1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HN9050000

CHEMICAL NAME :: 5H-Dibenz(b,f)azepine, 10,11-dihydro-3-chloro-5-(3-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 303-49-1

BEILSTEIN REFERENCE NO. :: 1323477

LAST UPDATED :: 199612

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C19-H23-Cl-N2

MOLECULAR WEIGHT :: 314.89

WISWESSER LINE NOTATION :: T C676 BN&T&J B3N1&1 EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 357 ug/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1981- Volume(issue)/page/year: 2,215,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 10 mg/kg/5D-I

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,406,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - coma Gastrointestinal - changes in structure or function of endocrine pancreas Gastrointestinal - decreased motility or constipation

REFERENCE :: JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 32,425,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 3400 ug/kg/47M-I

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - cardiomyopathy including infarction

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 3,698,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 613 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 24,335,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 149 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 24,335,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Behavioral - wakefulness Behavioral - changes in motor activity (specific assay)

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2618152

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,448,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 13,485,1976 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2857 ug/kg

SEX/DURATION :: male 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - impotence

REFERENCE :: CJPSDF Canadian Journal of Psychiatry. (Keith Health Care Communications, 289 Rutherford Rd. South, Suite 11, Brampton, ON L6W 3R9, Canada) Volume(issue)/page/year: 27,148,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 50 mg/kg

SEX/DURATION :: female 38-47 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 24(1),42A,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 6850 mg/kg

SEX/DURATION :: female 1-39 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :: JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 29,479,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 420 mg/kg

SEX/DURATION :: lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical

REFERENCE :: PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 56,93,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 400 mg/kg

SEX/DURATION :: female 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - physical

REFERENCE :: PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 56,93,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 66 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

REFERENCE :: PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976- Volume(issue)/page/year: 79,236,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 150 mg/kg

SEX/DURATION :: female 7-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

REFERENCE :: JNGSE8 Journal of Neural Transmission. General Section. (Springer-Verlag, Postfach 367, A-1011, Vienna, Austria) V.78- 1989- Volume(issue)/page/year: 90,113,1992

危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R20/21/22
安全声明 (欧洲)	S36
WGK德国	3
RTECS号	HN9055000
海关编码	2933990090

14171-67-6结构式

14171-67-6

~83%

303-49-1结构式

303-49-1

文献：Tetrahedron Letters, , vol. 51, # 43 p. 5690 - 5693

上游产品 1
14171-67-6
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303-48-0 14171-67-6

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
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Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%