106-93-4

106-93-4结构式

常用中文名：1,2-二溴乙烷
常用英文名：1,2-Dibromoethane
CAS号：106-93-4
分子式：C₂H₄Br₂
分子量：187.861
相关类别：有机原料烃类化合物及其衍生物烃类卤化物
发布时间：2018-03-18 08:00:00
更新时间：2024-01-02 16:05:16
【用途一】
用作有机合成中间体
【用途二】
用于有机合成，也用作溶剂
【用途三】
用作乙基化试剂、溶剂；农业上用作杀线虫剂、合成植物生长调节剂；医药上用作合成二乙基溴苯乙腈中间体，溴乙烯、乙烯叉二溴苯阻燃剂；还用作汽油抗震液中铅的消除剂、金属表面处理剂和灭火剂等。车用汽油采用二溴乙烷与二氯乙烷的混合物以降低成本，而航空汽油，则用纯二溴乙烷。
【用途四】
用作乙基化试剂、溶剂

中文名	二溴乙烷
英文名	1,2-dibromoethane
中文别名	溴化乙烯乙撑二溴二溴化乙烷二溴化乙烯溴化乙烷亚乙基二溴 1,2-二溴乙烷(EDB)
英文别名	Ethane, 1,2-dibromo- Glycol bromide 1,2-Dibromoethane EDB Bromuro di etile Dibromoethane α,β-Dibromoethane EINECS 203-444-5 1,2-dibromo ethylene Dibromoethane, 1,2- Ethylene dibromide sym-Dibromoethane Ethylene Bromide 1,2-Dibromo-ethane 1,2-bromoethane 1,2-Ethylene dibromide MFCD00000233 Ethane,1,2-dibromo

密度	2.1±0.1 g/cm3
沸点	130.2±8.0 °C at 760 mmHg
熔点	9 °C
分子式	C₂H₄Br₂
分子量	187.861
闪点	12.6±17.7 °C
精确质量	185.867966
LogP	2.08
外观性状	透明液体
蒸汽密度	~6.5 (vs air)
蒸汽压	12.0±0.2 mmHg at 25°C
折射率	1.521
储存条件	1.储存注意事项储存于阴凉、通风的库房。远离火种、热源。保持容器密封。应与氧化剂、碱金属、食用化学品分开存放，切忌混储。储区应备有泄漏应急处理设备和合适的收容材料。 2.贮运条件和防护要求同（一）溴甲烷，并避免与铝、镁、钾、钠等接触或与强碱和富氯物质接触。国际航空运输联合法规为第７２７条毒物Ｂ。
稳定性	1.在光作用下部分发生分解。与强碱反应生成溴代乙烯。 2.蒸气有毒，浓度高时能引起麻醉作用，全麻时会引起肺水肿致死。空气中最低中毒浓度２５×１０－６。吸入致死浓度１０００×１０－６。对啮齿动物有致癌作用。空气中最高容许浓度１３０×１０－９。蒸气刺激呼吸道，损伤肝、肾。液体接触皮肤可致溃烂。受到沾污时，应立即脱去外衣，擦干皮肤。生产场所要求通风良好，备有防毒面具和防护服等。 3.具有中度麻醉作用，易被皮肤吸收，其蒸气刺激眼黏膜和上呼吸道。麻醉性小，但能引起感觉迟钝、抑郁、呕吐。服用40g即可致死。慢性中毒时，能引起眼球结膜炎、支气管炎、喉头炎、食欲不振、抑郁等症状。潜在致癌物。嗅觉阈浓度199.94mg/m3。工作场所最高容许浓度为192.25 mg/m3。 4.稳定性稳定 5.禁配物碱金属、强氧化剂 6.避免接触的条件光照、受热 7.聚合危害不聚合 8.分解产物溴化氢
水溶解性	4 g/L (20 ºC)
分子结构	1、摩尔折射率：26.77 2、摩尔体积（cm³/mol）：87.9 3、等张比容（90.2K）：216.0 4、表面张力（dyne/cm）：36.4 5、极化率：10.61
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:0 4.可旋转化学键数量:1 5.互变异构体数量:无 6.拓扑分子极性表面积0 7.重原子数量:4 8.表面电荷:0 9.复杂度:6 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：无色有甜味的液体，有氯仿味。 2.熔点（℃）：9.97 3.沸点（℃）：131~132 4.相对密度（水=1）：2.17 5.相对蒸气密度（空气=1）：6.48 6.饱和蒸气压（kPa）：2.32（30℃） 7.临界压力（MPa）：7.15 8.辛醇/水分配系数：1.96 9.溶解性：微溶于水，可混溶于多数有机溶剂。 10.黏度（mPa·s,25ºC）：0.01613 11.蒸发热（KJ/mol,b.p.）：190.9 12.熔化热（KJ/mol）：10.84 13.生成热（KJ/mol,25ºC,液体）：80.805 14.燃烧热（KJ/mol,液体）：1217.9 15.比热容（KJ/(kg·K),定压）：0.72 16.电导率（S/m,25ºC）：1.28×10^-11 17.溶解度（%,水,25ºC）：0.54 18.体膨胀系数（K^-1,15~30ºC）：0.000958 19.相对密度（20℃，4℃）：2.1791 20.常温折射率（n²⁰）：1.5387 21.溶度参数(J·cm^-3)^0.5：20.656 22.van der Waals面积（cm²·mol^-1）：6.860×10⁹ 23.van der Waals体积（cm³·mol^-1）：49.260 24.气相标准声称热(焓)( kJ·mol^-1) ：-37.5 25.气相标准熵(J·mol^-1·K^-1) ：329.74 26.气相标准生成自由能( kJ·mol^-1)：-9.17 27.液相标准声称热(焓)( kJ·mol^-1)：-79.2 28.液相标准熵(J·mol^-1·K^-1) ：223.30 29.液相标准生成自由能( kJ·mol^-1)：-17.6 30.液相标准热熔(J·mol^-1·K^-1)：131.8

国标编号:	61565
ＣＡＳ:	106-93-4
中文名称:	1，2-二溴乙烷
英文名称:	1，2-dibromoethane
别名:	乙撑二溴
分子式:	C₂H₄Br₂；BrCH₂CH₂Br
分子量:	187.88
熔点:	9.3℃ 沸点：131.4℃
密度:	相对密度(水=1)2.17；
蒸汽压:	30℃
溶解性:	微溶于水，可混溶于多数有机溶剂
稳定性:	稳定
外观与性状:	无色质重有甜味的液体
危险标记:	14(有毒品)
用途:	用作溶剂，用于有机合成，制造杀虫剂、药品等

2、对环境的影响
该物质对环境有危害，对大气臭氧层有极强破坏力。对哺乳动物和鸟类应给予特别注意。
一、健康危害
侵入途径：吸入、食入、经皮吸收。
健康危害：具有中度麻醉作用。对皮肤粘膜有刺激作用。重者可致肺炎和肺水肿。对中枢神经有抑制作用。可致肝、肾损害。

急性中毒：可有头痛、头晕、耳鸣、全身无力、面色苍白、恶心、呕吐，可死于心力衰竭。引起皮炎和结膜炎。
二、毒理学资料及环境行为
毒性：潜在致癌物。
急性毒性：LD ₅₀108mg/kg(大鼠经口)；300mg/kg(兔经皮)；LC ₅₀0.384g/m ³(大鼠吸入)；人经口140mg/kg，致死。
亚急性慢性毒性：大鼠/兔吸入0.768g/m ³×7小时/日×5日/周×6个月，实验动物死亡率较对照高存活动物和肺、肝、肾重量增加。
致突变性：微生物致突变：鼠伤寒沙门氏菌500nmol/皿；大肠杆菌20uL/皿。姊妹染色体交换：人淋巴细胞10nmol/L。
生殖毒性：大鼠吸入最低中毒浓度(TCL0)：80ppm (24小时)，致胎鼠死亡。大鼠吸入最低中毒浓度(TCL0)对睾丸、附睾、输精管、性腺、尿道及雄性生育指数有影响。
致癌性：大鼠吸入20ppm×7小时/日×18月，肝细胞癌及肝血管肉瘤等。
危险特性：受高热分解产生有毒的溴化物气体。与强氧化剂接触可发生化学反应。
燃烧(分解)产物：溴化氢。 3、现场应急监测方法
　 4、实验室监测方法
气相色谱法《水和废水标准检验法》19版译文，江苏省监测中心
色谱/质谱法，美国EPA524.2方法 5、环境标准

美国	车间卫生标准	5ppm
美国(1981)	食物和饲料中容许残留限值	0.001mg/kg(大豆)
	嗅觉阈浓度	26ppm

6、应急处理处置方法

一、泄漏应急处理
迅速撤离泄漏污染区人员至安全区，并立即隔离150米，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿防毒服。不要直接接触泄漏物。尽可能切断泄漏源，防止进入下水道、排洪沟等限制性空间。小量泄漏：用砂土、蛭石或其它惰性材料吸收。大量泄漏：构筑围堤或挖坑收容。用泡沫覆盖，降低蒸气灾害。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。
废弃物处置方法：用控制焚烧法，焚烧系统要按装洗涤器和贮灰装置。
二、防护措施
呼吸系统防护：空气中浓度超标时，应选择佩带自吸过滤式防毒面具(半面罩)。
眼睛防护：戴安全防护眼镜。
身体防护：穿透气型防毒服。
手防护：戴防化学品手套。
其它：工作现场禁止吸烟、进食和饮水。工作毕，沐浴更衣。单独存放被毒物污染的衣服。洗后备用。注意个人清洁卫生。
三、急救措施
皮肤接触：脱去被污染的衣着，用肥皂水和清水彻底冲洗皮肤。就医。
眼睛接触：提起眼睑，用流动清水或生理盐水冲洗，就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入：饮足量温水，催吐，就医。
灭火方法：消防人员须佩戴防毒面具、穿全身消防服。灭火剂：泡沫、干粉、二氧化碳、砂土。

毒理学数据:

1.急性毒性

LD50：108mg/kg（大鼠经口）；300mg/kg（大鼠经皮）；300mg/kg（兔经皮）

LC50：14300mg/m³,（大鼠吸入，30min）

2.刺激性家兔经皮：1%，14d，严重刺激。

3.致突变性微生物致突变：鼠伤寒沙门菌500nmol/皿；大肠杆菌20μl/皿。姐妹染色单体交换：人淋巴细胞10nmol/L。微核试验：人淋巴细胞1mmol/L。DNA抑制：人淋巴细胞5ml/L。哺乳动物体细胞突变：人淋巴细胞5mg/L。

4.致畸性大鼠孕后6~15d吸入最低中毒剂量（TCLo）32ppm（23h），致肌肉骨骼系统发育畸形。

5.致癌性 IARC致癌性评论：G2A，可能人类致癌物。

6.其他大鼠吸入最低中毒浓度（TCLo）：80ppm（24h），致胎鼠死亡。大鼠吸入最低中毒浓度（TCLo）；对睾丸、附睾、输精管、性腺、尿道及雄性生育指数有影响。

生态学数据:

1.生态毒性LC50：18mg/L（48h）（蓝鳃太阳鱼）

2.生物降解性

好氧生物降解（h）：672~4320

厌氧生物降解（h）：48~360

3.非生物降解性

空气中光氧化半衰期（h）：257~2567

一级水解半衰期（h）：19272

4.其他有害作用该物质对环境有危害，对哺乳动物和鸟类应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KH9275000

CHEMICAL NAME :: Ethane, 1,2-dibromo-

CAS REGISTRY NUMBER :: 106-93-4

BEILSTEIN REFERENCE NO. :: 0605266

LAST UPDATED :: 199712

DATA ITEMS CITED :: 164

MOLECULAR FORMULA :: C2-H4-Br2

MOLECULAR WEIGHT :: 187.88

WISWESSER LINE NOTATION :: E2E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - urine volume decreased

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 108 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14300 mg/m3/30M

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 146 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - body temperature decrease Skin and Appendages - corrosive (after topical exposure)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Liver - hepatitis (hepatocellular necrosis), diffuse

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 ppm/3H

TOXIC EFFECTS :: Nutritional and Gross Metabolic - conditioned vitamin deficiency Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - hepatitis (hepatocellular necrosis), zonal

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 79 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 ppm/6H/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 ppm/7H/9D-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg/2D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 ppm/6H/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 50 ppm/7H/70D-I

TOXIC EFFECTS :: Behavioral - excitement Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 ppm/7H/4D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 ppm/7H/80D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 162 mg/kg/7D-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Biochemical - Metabolism (Intermediary) - lipids including transport

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 486 mg/kg/21D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 540 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Blood - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 ppm/6H/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Vascular - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 gm/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 ppm/6H/90W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 gm/kg/62W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 gm/kg/61W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 gm/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 gm/kg/57W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6630 mg/kg/34W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 gm/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 ppm/7H/78W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Endocrine - adrenal cortex tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7000 mg/kg/47W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 gm/kg/44W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 ppm/6H/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 ppm/6H/88W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Vascular - tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 88 ppb/8H

SEX/DURATION :: male 5 year(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 66670 ppb/4H

SEX/DURATION :: female 3-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 80 ppm/23H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 89 ppm/7H

SEX/DURATION :: male 10 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 39 ppm/7H

SEX/DURATION :: female 3 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 80 ppm/7H

SEX/DURATION :: female 3 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 25 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 38 ppm/23H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 20 ppm/23H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 38 ppm/23H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 32 ppm/23H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 225 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 93600 ug/kg

SEX/DURATION :: male 12 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Heritable translocation test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: DNA adduct

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TEST SYSTEM :: Mammal - species unspecified

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 18,743,1980 *** REVIEWS *** ACGIH TLV-Animal carcinogen (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,195,1977 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,204,1987 IARC Cancer Review:Group 2A IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,204,1987 TOXICOLOGY REVIEW BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925- Volume(issue)/page/year: 54,413,1978 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB83-184325 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 20 ppm (145 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,15,1973 OSHA PEL (Gen Indu):8H TWA 20 ppm;CL 30 ppm;Pk 50 ppm/5M/8H CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 25 ppm (190 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 25 ppm (190 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 25 ppm (190 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.13 ppm (1 mg/m3) JAN 1993 OEL-AUSTRALIA;Skin;Carcinogen JAN 1993 OEL-BELGIUM;Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.1 ppm (1 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:TWA 20 ppm (145 mg/m3);STEL 30 ppm;Skin;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-HUNGARY:STEL 0.8 mg/m3;Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 20 ppm (155 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 25 ppm (190 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.8 mg/m3);Skin;Carcinogen JAN 1993 OEL-THAILAND:TWA 20 ppm;STEL 30 ppm JAN 1993 OEL-TURKEY:TWA 25 ppm (190 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (8 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHYLENE DIBROMIDE-air:CA TWA 0.045 ppm;CL 0.13 ppm/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 23660 No. of Facilities: 438 (estimated) No. of Industries: 5 No. of Occupations: 8 No. of Employees: 7921 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 23660 No. of Facilities: 496 (estimated) No. of Industries: 7 No. of Occupations: 13 No. of Employees: 8559 (estimated) No. of Female Employees: 792 (estimated)

符号	GHS06, GHS08, GHS09
信号词	Danger
危害声明	H301-H311-H315-H319-H331-H335-H350-H411
警示性声明	P201-P261-P273-P280-P301 + P310-P305 + P351 + P338
个人防护装备	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲)	T:Toxic
风险声明 (欧洲)	R23/24/25;R36/37/38;R45;R51/53
安全声明 (欧洲)	S53-S45-S61-S36/37/39-S26-S36/37-S16-S7
危险品运输编码	UN 1605 6.1/PG 1
WGK德国	3
RTECS号	KH9275000
包装等级	I
危险类别	6.1
海关编码	2903310000

上游产品 10
54509-73-8 105089-47-2 71-43-2 74-86-2
107-21-1 107-06-2 593-60-2 67-56-1
540-63-6 74-96-4
下游产品 10
1112193-37-9 106-58-1 105-84-0 105-78-2
110-70-3 1074-56-2 6483-50-7 111-74-0
105-93-1 24426-33-3

海关编码	2903310000

1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	2680852-60-0
930439-75-1	1018584-77-4
1375289-11-4	849349-65-1