799842-07-2

• 常用中文名：瑞舒伐他中间体Z-8
• 常用英文名：N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
• CAS号：799842-07-2
• 分子式：C₁₆H₁₉BrFN₃O₂S
• 分子量：416.308
• 发布时间：2018-05-09 08:00:00
• 更新时间：2026-07-01 16:51:52

名称

• 中文名: 5-(溴甲基)-4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰)氨基]嘧啶
• 英文名: N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide
• 中文别名: 瑞舒伐他汀溴化物; N-(5-(溴甲基)-4-(4-氟苯基)CHEMICALBOOK-6-异丙基嘧啶-2-基)-N-甲基甲磺酰胺; 瑞舒伐他汀钙中间体; N-(5-(溴甲基)-4-(4-氟苯基)-6-异丙基嘧啶-2-基)-N-甲基甲磺酰胺(瑞舒伐他汀杂质); 罗苏伐他汀溴甲基杂质; 5-( 溴甲基 )-4-(4- 氟苯基 )-6- 异丙基 -2-[ 甲基 ( 甲磺酰 ) 氨基 ] 嘧啶 (Z7 溴 ); 瑞舒伐他汀溴甲基杂质; 瑞舒伐他汀溴乙基杂质; 阿折地平杂质Z8; 瑞舒伐他汀杂质79; 瑞舒伐他汀钙Z-8; N-[4-(4-氟苯基)-5-溴甲基-6-异丙基-2-嘧啶基]-N-甲基甲磺酰胺; 4-(4-氟苯基)-6-异丙基-2-(N-甲基-N-甲磺酰氨基)-5-(溴甲基)-嘧啶; 4-(4-氟苯基)-5-溴甲基-6-异丙基-2-[(N-甲基-N-甲磺酰胺基)]-嘧啶; N-(5-(溴甲基)-4-(4-氟苯基)-6-异丙基嘧啶-2-基)-N-甲基甲磺酰胺; 瑞舒伐他汀杂质
• 英文别名: 5-(BROMOMETHYL)-4(FLUOROPHENYL)6-ISOPROPYL-2METHYL(METHYLSULFONYL ) AMINOPYRIMIDINE; 5-(Bromomethyl)-4-(4-Fluorophenyl)-6-Isopropyl-3-[Methyl(Methylsulfonyl)Amino]Pyrimidine; 4-(4-Fluorophenyl)-5-broMineMethyl-6-Isopropyl-2-(N-Methyl-N-MethylsulfonylaMino)PyriMidine; Rosuvastatin Z-8; N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamid; 2-((Z)-2-((10-(((Z)-1-(dicyanomethylene)-5,6-difluoro-3-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)-12,13-bis(2-phenethyl-6-phenylhexyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2'',3'':4',5']thieno[2',3':4,5]pyrrolo[3,2-g]thieno[2',3':4,5]thieno[3,2-b]indol-2-yl)methylene)-6,7-difluoro-3-oxo-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-ylidene)malononitrile Chemical Formula: C110H104F4N8O2S5; Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethylsulfonylaMino)PyriMidine PRODUCT:CheMical naMe:Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethylsulfonylaMino)PyriMidine; N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide (BRO-Z7 ); N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide; N-(5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (Rosuvastatin Impurity）; 5-(Bromomethyl)-4-(4-Fluorophenyl)-6-Isopropyl-2 -[(N-Methyl-N-Methylsulfonyl)Amino]Pyrimidine; N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl; N-(4-(4-Fluorophenyl)-5-bromomethyl-6- isopropylpyrimidin-2-yl)-N-methyl methane sulfonamide; Chemical name:Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidine; N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide; Rosuvastatin Impurity 079; 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidine, min; Rosuvastatin Bromomethyl Impurity; N-[5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide; N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropropyl-pyrimidine-2-yl]-N-methylmethane sulfonamide; Diphenyl[4-(4-fluorophenyl)-6-isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidine; 5-(Bromomethyl)-4-(4-Fluorophenyl)-6-Isopropyl-2-[Methyl(Methylsulfonyl)Amino]Pyrimidine; 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(met; 5-Bromomethyl 4 Flurophenyl 6-Isopropyl 2 Methyl Methyl Sulf Onyl Amino Pyrimidine; N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide; Rosuvastatin Impurity; N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropropyl-pyrimidine-2-yl]-N-methylmethane sulfonamid; rosuvastatin intermediates Z-8; N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methyl methane sulfonamide; N-[5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide; MethanesulfonaMide, N-[5-(broMoMethyl)-4-(4-fluorophenyl)-6-(1-Methylethyl)-2-pyriMidinyl]-N-Methyl; ： 5-(BroMoMethyl)-4-(4-fluorophenyl)-6-isopropyl-2; Rosuvastatin Intermediate Z8; 5-(BROMOMETHYL)-4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(METHYL(MET HYLSULFONYL)AMINO)PYRIMIDINE; 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 531.2±60.0 °C at 760 mmHg
• 分子式: C₁₆H₁₉BrFN₃O₂S
• 分子量: 416.308
• 闪点: 275.0±32.9 °C
• 精确质量: 415.036530
• PSA: 71.54000
• LogP: 2.61
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.586
• 储存条件: 2-8°C，保存于惰性气体中

合成路线

925422-06-6 ~96% 799842-07-2

文献：YUHAN CORPORATION; JU, Hyun; JOUNG, Sang-Sun; YI, Hyun-Jik; KHOO, Ja-Heouk; LIM, Jong-Chul; KIM, Jae-Gyu Patent: WO2012/2741 A2, 2012 ; Location in patent: Page/Page column 19 ; WO 2012/002741 A2

147118-36-3 ~10% 799842-07-2

文献：Kaneka Corporation Patent: EP2351762 A1, 2011 ; Location in patent: Page/Page column 9 ;

953776-62-0 ~90% 799842-07-2

文献：LEK PHARMACEUTICALS D.D.; CASAR, Zdenko; STERK, Damjan; JUKIC, Marko Patent: WO2012/13325 A1, 2012 ; Location in patent: Page/Page column 57-58 ;

114433-94-2 ~% 799842-07-2

文献：WO2012/13325 A1, ;

1354455-77-8 ~% 799842-07-2

文献：WO2012/13325 A1, ;

1207460-34-1 ~% 799842-07-2

文献：WO2012/13325 A1, ;

147118-30-7 ~% 799842-07-2

文献：WO2012/2741 A2, ; WO 2012/002741 A2

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