503610-43-3

• 常用中文名：瑞舒伐他汀-5S-内酯
• 常用英文名：Rosuvastatin Lactone
• CAS号：503610-43-3
• 分子式：C₂₂H₂₆FN₃O₅S
• 分子量：463.522
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-08-24 18:38:46
• 更新时间：2026-07-03 04:20:40
• Rosuvastatin lactone 是 Rosuvastatin (HY-17504A) (HMG-CoA 抑制剂) 的代谢物。

名称

• 中文名: 瑞舒伐他汀内酯
• 英文名: Rosuvastatin Lactone
• 中文别名: 瑞舒伐他汀杂质D-D); 瑞舒伐他汀钙内酯 化降解产物; 杂质D; 吲哚洛尔杂质B; 瑞舒伐他汀杂质6(瑞舒伐他汀杂质D); 瑞舒伐他汀杂质D(内脂杂质); 瑞舒伐他汀杂质D; 罗苏伐他汀杂质D; 瑞舒伐他汀内脂; 瑞舒伐他汀钙杂质D; N-(4-(4-氟苯基)-5-((E)-2-((2S,4R)-4-羟基-6-氧代四氢-2H-吡喃-2-基)乙烯基)-6-异丙基嘧啶-2-基)-N-甲基甲磺酰胺; 罗舒伐他汀内酯; 舒伐他汀杂质D; 瑞舒伐他汀杂质对照品
• 英文别名: 3-Benzofuranpropanenitrile,β-oxo; RosuvastatinLactone; rosuvastatin lactone, min; Rosuvastatin calcium impurity D; (3R,5R)-Rosuvastatin Lactone; Rosuvastatin Impurity 6(Rosuvastatin Impurity D); Rosuvastatin Impurity D (Calcium Salt); N-[4-(4-Fluorophenyl)-5-[(E)-2-[(2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethenyl]-6-(1-methyl; Rosuvastatin Impurity-D(lactone); Rosuvastatin Impurity D (Rosuvastatin (3R,5S)-Lactone); N-[4-(4-Fluorophenyl)-5-{(E)-2-[(2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]vinyl}-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide; Rosuvastatin Impurity D; N-[4-(4-Fluorophenyl)-5-[(E)-2-[(2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethenyl]-6-(1-methylethyl)pyrimidin-2-yl]-N-methylmethanesulfonamide (Rosuvastatin Lactone); Rosuvastatin Lactone-d3; Rosuvastatin Impurity D N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)- tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2- pyrimidinyl]-N-methyl-methanesulfonamide; Rosuvastatin LactoneQ: What is Rosuvastatin Lactone Q: What is the CAS Number of Rosuvastatin Lactone Q: What is the storage condition of Rosuvastatin Lactone Q: What e the applications of Rosuvastatin Lactone; Rosuvastatin Imp D; (3R,5R)-ROSUVASTATIN LACTONE; 1-[4-[2-HYDROXY-3-[(1-METHYL-ETHYL)AMINO]PROPOXY]-1H-INDOL-1-YL]-3-[(1-METHYLETHYL)AMINO]PROPAN-2-OL; Rosuvastatin-5R-lactone; Rosuvastatin-5S-lactone; N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyriMidin-2-yl)-N-MethylMethanesulfonaMide; Rosuvastatin calcium-5; ROSUVASTATIN-5S-LACTONE; Rosuvastatin Impurity 1/Rosuvastatin Impurity D/Rosuvastatin (3R,5S)-Lactone; Rosuvastatin Lactone I (Rosuvastatin 5S Lactone) Impurity D); Rosuvastatin lactone; Rosuvastatin (5S)-Lactone/N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methylmethanesulfonamide/N-[4-(4-Fluorophenyl)-5-{(E)-2-[(2S ,4R )-4-hydroxy-6-oxotetrahydro-2H -pyran-2- yl]vinyl}-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide; Rsosuvastatin Lactone; rahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methylmethanesulfonamide; Methanesulfonamide, N-[4-(4-fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methyl; N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methylmethanesulfonamide; Rosuvastatin lactone, >=; Benzenesulfonylchloride,4-methoxy-2-methyl-5-(2-methylethyl); Rosuvastatin (5S)-Lactone/N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methylmethanesulfonam; Rosuvastatin Lactone impurity D; N-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-5-[(1E)-2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyriMidinyl]-N-Methyl-MethanesulfonaMide

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 695.0±65.0 °C at 760 mmHg
• 熔点: 131℃
• 分子式: C₂₂H₂₆FN₃O₅S
• 分子量: 463.522
• 闪点: 374.1±34.3 °C
• 精确质量: 463.157715
• PSA: 118.07000
• LogP: 0.42
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.615
• 储存条件: -20℃

生物活性

• 描述: Rosuvastatin lactone 是 Rosuvastatin (HY-17504A) (HMG-CoA 抑制剂) 的代谢物。
• 相关类别:
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Lee HB, et al. Occurrence and fate of rosuvastatin, rosuvastatin lactone, and atorvastatin in Canadian sewage and surface water samples. Chemosphere. 2009 Nov;77(10):1285-91.

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