866783-13-3

• 常用中文名：(1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐
• 常用英文名：(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
• CAS号：866783-13-3
• 分子式：C₁₂H₁₈ClNO₂
• 分子量：243.730
• 发布时间：2018-12-25 13:44:09
• 更新时间：2026-07-02 12:25:11

名称

• 中文名: (1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐
• 英文名: (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
• 中文别名: (1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐相关信息; 伊伐布雷定杂质17; 伊伐布雷定杂质4盐酸盐; 3,4-二甲氧基二环[4.2.0]辛-1,3,5-三烯-7-基)甲胺盐酸盐; 盐酸依伐布雷定中间体; 伊伐布雷定杂质7 HCL; (1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐(伊伐布雷定中间体); 盐酸伊伐布雷定主链; 伊伐布雷定杂质E; (1s)-4.5-二甲氧基-1［(甲基氨基)甲基］苯并环丁烷盐酸盐; [((7S)-3,4-二甲氧基双环[4.2.0]辛-1,3,5 三烯-7-基)甲基]甲胺; (1S)4,5-二甲氧基-1(甲基氨基甲基)-苯并环丁烷; 4,5-二甲氧基-1-[甲基氨基甲基]苯并环丁烷盐酸盐; 伊伐布雷定相关化合物12; 伊伐布雷定杂质17 HCL; (1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐 6; (1S)-4,5-二甲氧基-1-[(甲氨基)甲基]苯并环丁烷 盐酸盐; 伊伐布雷定中间体一; (1S)-4,5-二甲氧基-1-[(甲; 伊伐布雷定杂质85; 5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐; 盐酸伊伐布雷定主链/(1S)-4,5-二甲氧基-1-[(甲基氨基)甲基]苯并环丁烷盐酸盐; 伊伐布雷定杂质7 盐酸盐; (7S)-3,4-二甲氧基-N-甲基-双环[4,2,0]辛-1,3,5-三烯-7-甲基氨基盐酸盐; 伊伐布雷定杂质17盐酸盐; 伊伐布雷定杂质6 盐酸盐; (1S)-4,5-二甲氧基-1-甲氨基甲基-苯并环丁烷盐酸盐,伊伐布雷定中间体; 1-(3,4-二甲氧基双环[4.2.0]八烯-1,3,5-三烯-7-基)-N-甲基亚甲胺盐酸盐; 伊伐布雷定中间体3; 4,5-二甲氧基-1-(甲基氨基甲基)苯并环丁烷; 盐酸伊伐布雷定杂质(Y655); 伊伐布雷定中间体; (S)-1-(3,4-二甲氧基双环[4.2.0] OCTA-1,3,5-三烯-7-基)-N-甲基甲胺盐酸盐; (1S)-4.5-二甲氧基-1-甲氨基甲基-苯并环丁烷盐酸盐(手性胺)
• 英文别名: (1S)-4,5-DiMethoxy-1-[(MethylaMino)Methyl]benzocyclobutane; Ivabradine Impurity 17 HCl; Ivabradine Impurity 7 HCL; Ivabradine related compound 12; (1S)-4,5-Dimethoxy-1-(Methylaminomethyl)-Benzocyclobutane Hcl; (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocycl; (1S)-4,5-Dimethoxy-1-[(methylamine)methyl]benzocyclobutane HCl; S-4,5-Dimethoxy-1-[(methylamino)methyl]benzo cyclobutane hydrochloride; (S)-N-[(4,5-diMethoxybenzocyclobut-1-yl)Methyl ]-N-MethylaMine h; 3,4-diMethoxy-N-Methyl-bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine hydrochloride; Bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine, 3,4-dimethoxy-N-methyl-, (7S)-, hydrochloride (1:1); 3,4-dimethoxy-N-methyl-bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride (For Ivabradine); (1R)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride; (1S)-4,5-DiMethoxy-1-[(MethylaMino)Methyl]benzoc; {[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amine hydrochloride; Ivabradine Impurity 85; Ivabradine related compound 11(Hydrochloride); Bicyclo[4.2.0]octa-1,3,5-triene-7-MethanaMine, 3,4-diMethoxy-N-Methyl-, hydrochloride; Ivabradine hydrochloride main chain; Ivabradine related compound; Ivabradine RC 6 (HCl); Ivabradine intermediate1; (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochlorideY655; 1-[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]-N-methylmethanamine,hydrochloride; N-[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]-N-methylamine hydrochloride; (1S)-4,5-Dimethoxy-1-(methylaminoethyl)benzocyclobutane HCl; (S)-(4,5-diMethoxy-1,2-dihydrocyclobutabenzen-1-yl)MethanaMine; 1-[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride (1:1); (7S)-3,4-Dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-methanamine hydrochloride; (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane h; (1S)-4; Ivabradine Intermediate; [N-[[3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL] carbonyl]-N-METHYLAMINE]; Ivebradine impurity 3; 5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride; (S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine hydrochloride; Ivabradine Amine Hydrochloride

物化性质

• 沸点: 338.6ºC at 760 mmHg
• 分子式: C₁₂H₁₈ClNO₂
• 分子量: 243.730
• 闪点: 158.6ºC
• 精确质量: 243.102600
• PSA: 30.49000
• LogP: 2.75580
• 储存条件: 室温，干燥

安全

• 海关编码: 2942000000

合成路线

866783-12-2 ~90% 866783-13-3

文献：Lerestif, Jean-Michel; Blanco, Isaac Gonzalez; Lecouve, Jean-Pierre; Brigot, Daniel Patent: US2005/261376 A1, 2005 ; Location in patent: Page/Page column 3 ;

1220993-43-0 ~88% 866783-13-3

文献：RICHTER GEDEON NYRT.; UJVARI, Viktor; BODI, Jozsef; FARAGO, Janos; SZKE, Katalin; FAIGL, Ferenc; NEMET, Zoltan; TEMESVARI, Krisztina; KISS, Robert; MATRAVOeLGYI, Bela; KASSAI, Ferencne; KISS-BARTOS, Dorottya Patent: WO2011/138625 A1, 2011 ; Location in patent: Page/Page column 42 ;

35202-54-1 ~% 866783-13-3

文献：WO2011/138625 A1, ;

41234-23-5 ~% 866783-13-3

文献：WO2011/138625 A1, ;

1220993-48-5 ~% 866783-13-3

文献：WO2011/138625 A1, ;

35249-62-8 ~% 866783-13-3

文献：WO2011/138625 A1, ;

1220993-44-1 ~% 866783-13-3

文献：WO2011/138625 A1, ;

1346558-07-3 ~% 866783-13-3

文献：WO2011/138625 A1, ;

1220993-45-2 ~% 866783-13-3

文献：WO2011/138625 A1, ;

上下游产品

上游产品  5
866783-12-2 35202-54-1 41234-23-5 35249-62-8
1346558-07-3
下游产品  3
155974-00-8 148849-67-6 1086026-31-4

海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%