485-91-6

• 常用中文名：别隐品碱
• 常用英文名：Allocryptopine
• CAS号：485-91-6
• 分子式：C₂₁H₂₃NO₅
• 分子量：369.411
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-05-03 08:00:00
• 更新时间：2026-07-07 20:02:36
• Allocryptopine,是一种从 Corydalis decumbens 中提取的延胡索乙素的衍生物。Allocryptopine 具有抗心律失常作用,能有效阻断 hERG 电流。

名称

• 中文名: Alpha-别隐品碱
• 英文名: allocryptopine
• 中文别名: A-别隐品碱(标准品); 别隐品碱 Allocryptopine; 别瘾品碱; 别隐品碱 标准品; ALLOCRYPTOPINE 别隐品碱; 別隱品鹼; Α-别隐品碱, 来源于博落回; 别克多品; 延胡索寅素; 别隐品碱、Α-别隐品碱; 别隐品碱,10 MM DMSO 溶液; 别隐品碱对照品; 别隐品碱;A-别隐品碱(标准品); 别隐品碱/生物碱; 别隐品碱/Α-别隐品碱; 3,4-二甲氧基-6-甲基-5,7,8,15-四氢-[1,3]二氧杂环戊烯并[4',5':4,5]苯并[1,2-G]苯并[c] azecin-14(6H)-酮; Α-别隐品碱; A-别隐品碱
• 英文别名: allo-Cryptopine; (2S,5R,6R)-6-[(2-amino-2-methyl-1-oxopropyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]htane-2-cboxylic acid; High purity ALLOCRYPTOPINE in stock; 5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methylbenzo[e][1,3]dioxolo[4,5-k][3]benzazecin-14(6H)-one; 5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methylbenzo(e)(1,3)dioxolo(4,5-k)(3)benzazecin-14(6H)-one; Thalictrimine; 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl[1,3]benzodioxolo[5,6-e]benzazecin-14(6H)-one; Fagarine I; Beta-HoMochelidonine; α-Allocryptopine; ALLOCRYPTOPINE //BP; 3,4-DIMETHOXY-6-METHYL-5,7,8,15-TETRAHYDRO-6H-BENZO[C][1,3]DIOXOLO[4',5':4,5]BENZO[1,2-G]AZECIN-14-ONE; ALLOCRYPTOPINE, ALPHA; Allocryptopine, 10 mM in DMSO; ALLOCRYPTOPINE; β-Homochelidonine; α-Allocryptopine-RM; 5,7,8,15-Tetrahydro-3,4-dimethoxy-6-methylbenzo[e][1,3]dioxolo[4,5-k]benzazecin-14(6H)-one; [1,3]Benzodioxolo[5,6-e]benzazecin-14(6H)-one, 5,7,8,15-tetrahydro-3,4-dimethoxy-6-methyl; ALPHA-ALLOCRYPTOPINE; α-Allocryptopine from Macleaya cordata (Willd.) R. Br; a-allo-Cryptopine; 3,4-Dimethoxy-6-methyl-5,7,8,15-tetrahydrobenzo[c][1,3]benzodioxolo[5,6-g]azecin-14(6H)-one; alpha-Fagine; C02134; 3,4-Dimethoxy-6-methyl-5,7,8,15-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-g]benzo[c]azecin-14(6H)-one; α-Fagarine

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 552.7±50.0 °C at 760 mmHg
• 分子式: C₂₁H₂₃NO₅
• 分子量: 369.411
• 闪点: 288.1±30.1 °C
• 精确质量: 369.157623
• PSA: 57.23000
• LogP: 3.64
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.574
• 储存条件: 2-8C

生物活性

• 描述: Allocryptopine,是一种从 Corydalis decumbens 中提取的延胡索乙素的衍生物。Allocryptopine 具有抗心律失常作用,能有效阻断 hERG 电流。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 参考文献:

  [1]. Xu B, et al. Effect of α-Allocryptopine on Delayed Afterdepolarizations and Triggered Activities in Mice Cardiomyocytes Treated with Isoproterenol. Evid Based Complement Alternat Med. 2015;2015:634172.

  [2]. Lin K, et al. Allocryptopine and benzyltetrahydropalmatine block hERG potassium channels expressed in HEK293 cells. Acta Pharmacol Sin. 2013 Jun;34(6):847-58.

合成路线

上下游产品

上游产品  7
29074-38-2 16211-68-0 61774-67-2 41759-47-1
47474-49-7 41759-48-2 633-65-8
下游产品  2
2086-83-1 6880-91-7