149394-66-1

• 常用中文名：西多福韦
• 常用英文名：Cidofovir Dihydrate
• CAS号：149394-66-1
• 分子式：C₈H₁₈N₃O₈P
• 分子量：315.22
• 相关类别： 原料药 人工合成抗感染类药 抗病毒类药
• 发布时间：2018-04-24 08:00:00
• 更新时间：2026-07-02 11:43:26
• Cidofovir是注射型巨细胞病毒(CMV)DNA聚合酶抑制剂。

名称

• 中文名: 西多福韦二水合物
• 英文名: cidofovir dihydrate
• 中文别名: (S)-(((1-(4-氨基-2-氧嘧啶-1(2H)-基)-3-羟丙基-2-基)氧基)甲基)膦酸二水合物; CIDOFOVIR DIHYDRATE西多福韦二水合物; 西多福韦二水物; 西多福韦 二水; 化合物：Cidofovir dihydrate; 化合物:Cidofovir dihydrate; 西多福韦二水
• 英文别名: 1-[(S)-3-Hydroxy-2-(phosphonoMethoxy)propyl]cytosine Hydrate; Cidofovir hydrate (1:2); Gs-0504; P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid hydrate (1:2); HPMPC DIHYDRATE;(S)-HPMPC DIHYDRATE; Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, dihydrate, (S); Cidofovir //BP; ({[(2S)-1-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid; (S)-[[2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic Acid; HPMPC dihydrate; Cidofovir 2-hydrate; (S)-HPMPC Hydrate; Vistide Hydrate; (S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl-1-(hydroxymethyl)ethoxy)methyl phosphonic acid; ({[(2S)-1-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-3-hydroxy-2-propanyl]oxy}methyl)phosphonic acid; CIDOFOVIR DIHYDRATE CRUDE-2; (S)-HPMPC dihydrate; (S)-1-(3-hydroxy-2-phosphonoMethoxypropyl)cytosine Hydrate; Cidofovir dihydrate - Bio-X; GS 0504 Hydrate; cidofovir dihyrate; [[(1S)-2-(4-Amino-2-oxo-1(2H)-pyriMidinyl)-1-(hydroxyMethyl)ethoxy]Methyl]phosphonic Acid Hydrate; (S)-(3-(4-amino-2-oxopyriMidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)Methylphosphonic acid dihydrate; Cidofovir dihydrate (HPMPC dihydrate; Cidofovir dihydrate; Cidofovir; Unii-jil713Q00n; P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid dihydrate; (S)-[[2-(4-Amino-2-oxo-1(2H)-pyriMidinyl)-1-(hydroxyMethyl)ethoxy]Methyl]phosphonic Acid Hydrate; (S)-[1-(4-Amino-2-oxo-pyriMidin-1(2H)-yl)-3-hydroxy-propan-2-yl]oxyMethylphosphonic acid dihydrate; Cidovir Hydrate; [1-(4-amino-2-oxo-1-pyrimidinyl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid dihydrate; Vistide; Cidofovir (dihydrate); Phosphonic acid,P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyriMidinyl)-1-(hydroxyMethyl)ethoxy]Methyl]-,hydrate (1:2); Drg-0145; Cidofovir hydrate

物化性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 609.5±65.0 °C at 760 mmHg
• 熔点: 260ºC (dec)
• 分子式: C₈H₁₈N₃O₈P
• 分子量: 315.22
• 闪点: 322.4±34.3 °C
• PSA: 157.71000
• LogP: -3.37
• 蒸汽压: 0.0±4.0 mmHg at 25°C
• 折射率: 1.656
• 储存条件: 室温，干燥

生物活性

• 描述: Cidofovir是注射型巨细胞病毒(CMV)DNA聚合酶抑制剂。
• 相关类别:
  信号通路 >> 抗感染 >> CMV
  研究领域 >> 感染
• 参考文献:

  [1]. Becker MN, et al. Isolation and characterization of cidofovir resistant vaccinia viruses. Virol J. 2008 May 14;5:58.

  [2]. Kazory A, et al. Simultaneous development of Fanconi syndrome and acute renal failure associated with cidofovir. J Antimicrob Chemother. 2007 Jul;60(1):193-4. Epub 2007 May 11.

  [3]. Segarra-Newnham M, et al. Use of cidofovir in progressive multifocal leukoencephalopathy. Ann Pharmacother. 2001 Jun;35(6):741-4.