1029877-94-8

• 常用中文名：琥珀酸曲格列汀
• 常用英文名：Trelagliptin succinate
• CAS号：1029877-94-8
• 分子式：C₂₂H₂₆FN₅O₆
• 分子量：475.470
• 相关类别： 医药中间体 原料药中间体
• 发布时间：2018-07-01 16:12:11
• 更新时间：2026-07-01 21:41:01
• Trelagliptin(SYR-472)是长效的DPP-4抑制剂。

名称

• 中文名: 曲格列汀琥珀酸盐
• 英文名: 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile,butanedioic acid
• 中文别名: 2-[[6-[(3R)-3-氨基-1-哌啶基]-3,4-二氢-3-甲基-2,4-二氧代-1(2H)-嘧啶基]甲基]-4-氟-苯甲腈琥珀酸盐; (R)-2-((6-(3-氨基哌啶-1-基)-3-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)甲基)-4-氟苯甲腈琥珀酸盐; 曲格列汀琥珀酸; 曲格列汀琥珀酸盐/SRY-472; 曲格列汀琥珀盐酸; 琥珀酸曲格列汀原料药; (R)-2-[[2,4-二氧代-3-甲基-6-(3-氨基-1-哌啶基)-1,2,3,4-四氢-1-嘧啶基]甲基]-4-氟苯腈琥珀酸盐; 抑制剂Trelagliptin succinate; 琥珀酸曲格列汀 (SSYYRR-472); 琥珀酸曲拉格列汀; 琥珀酸曲格列汀/含量测定; 曲格列汀琥珀酸盐 1029-8; 2-[[6-[(3R)-3-氨基-1-哌啶基]-3,4-二氢-3-甲基-2,4-二氧代-1(2H)-嘧啶基]甲基]-4-氟-苯甲腈琥珀酸; 曲格列汀杂质43; 盐酸曲格列汀; 曲格列汀琥珀酸盐,10 MM DMSO 溶液; 曲格列汀2; 琥珀酸盐曲格列汀; 琥珀酸曲格列汀TRELAGLIPTIN SUCCINATE (SYR-472); 琥珀酸曲格列汀 Trelagliptin Succinate; (R)-2-((6-(3-氨基哌啶-1-基)-3-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)甲基)-4-氟苄腈琥珀酸盐; [[2'-(2,5-二氢-5-氧代-1,2,4-恶二唑-3-基)[1,1'-联苯]-4-基]甲基]-2-乙氧基-1H-苯并咪唑-7-羧酸 (5-甲基; 曲格列汀杂质35 1/4丁二酸盐; 琥珀酸曲格列汀及中间体
• 英文别名: SYR 472 succinate; SYR-472 Trelagliptin succinat; relagliptin succinate; Trelagliptin succinat; Trelagliptin succinate ISO 9001：2015 REACH; Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-, butanedioate (1:1); Telagliptin Succinate; Benzoicacid,4-hydroxy-3,11-dimethoxy; Trelagliptin Succinate API; Trelagliptin Impurity 35 1/4Succinate; Trelagliptin succinate, >=; SYR 472; SYR-472 succinate; SRY-472; 2-[[6-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile,butanedioicacid; Troagliptin succinate; SYR-472 succinate. Trelagliptin; Butanedioic acid, compd. with 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile (1:1); SYR472 succinate; Troglitinesuccinate; Zafatek; (R)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-f; Trelagliptin (succinate); Trelagliptin succinate - SYR 111472 succinate | SYR; Tragliptin succinate; 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2butanedioic acid; Trelagliptin succinate, 10 mM in DMSO; Trogliptin succinate; (R)-2-[[6-(3-Amino-1-piperidyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl]methyl]-4-fluorobenzonitrile Succinate; Trelagliptin Succinate (SYR-472); Trelagliptin Impurity 81; Trelagliptin succinate [USAN]; SYR-472; 2-amino-1-(8-bromophenyl)ethanol; SYR 111472 succinate; chloro-bis-methylsulfanyl-borane; Trelagliptin succinate SYR 111472 succinate; Trelagliptin succinate high quality Cas number：1029-8; SYR-472 SUCCINATE; SYR472 SUCCINATE; SYR 472 SUCCINATE; Trelagliptin succinate(SRY-472); Trelagliptinsuccinate; 2-({[6-[(3R)-3-aminopipidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)- yl}methyl)-4-fluorobenzonitrile hydrogen butanedioate; Succinic acid - 2-({6-[(3R)-3-amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)-4-fluorobenzonitrile (1:1); SYR111472 Succinate; Triglitastat succinate; Troxagliptin succinate

物化性质

• 分子式: C₂₂H₂₆FN₅O₆
• 分子量: 475.470
• 精确质量: 475.186707
• PSA: 171.65000
• LogP: 1.23468
• 储存条件: -20℃

生物活性

• 描述: Trelagliptin(SYR-472)是长效的DPP-4抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 二肽基肽酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus

  [2]. Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus

  [3]. Long-term Study of SYR-472

  [4]. SYR-472 Open-label Study

安全

• 危害码 (欧洲): Xi