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1271738-59-0

1271738-59-0结构式

中文名	4-[4-(4,5-二氢-5,5-二甲基-2-噻唑基)-1-哌嗪基]-6-异丙基噻吩并[2,3-d]嘧啶
英文名	4-[4-(5,5-dimethyl-4H-thiazol-2-yl)piperazin-1-yl]-2-isopropyl-th ieno[2,3-d]pyrimidine
中文别名	4-(4-(5,5-二甲基-4,5-二氢噻唑-2-基)哌嗪-1-基)-6-异丙基噻吩并[2,3-D]嘧啶 MI-3,MENIN-MLL 相互作用抑制剂 4-[4-(4,5-二氢-5,5-二甲基-2-噻唑基)-1-哌嗪基]-6-异丙基噻吩并[2,3-D]嘧啶
英文别名	5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl) 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine MI-3 4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-6-isopropylthieno[2,3-d]pyrimidine 5-dihydro-5 Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl) 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine MI-3 (Menin-MLL Inhibitor) //BP 4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine MI-3, 10 mM in DMSO 4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-2-isopropylthieno[2,3-d]pyrimidine MI3;MI 3;MENIN-MLL INHIBITOR 3;THIENO[2;3-D]PYRIMIDINE; 4-[4-(4;5-DIHYDRO-5;5-DIMETHYL-2-THIAZOLYL)-1-PIPERAZINYL]-6-(1-METHYLETHYL) Menin-MLL inhibitor 3 MI-3 (Menin-MLL Inhibitor) MI-3MI-3(Menin-MLL inhibitor 3) MI3,MI-3,Apoptosis,inhibit,igenetic Reader Domain,Inhibitor

描述	MI-3 是 Menin-MLL 相互作用抑制剂,IC50为 648 nM。
相关类别	信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶研究领域 >> 癌症
参考文献	[1]. Grembecka J, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nature Chemical Biology (2012), 8(3), 277-284.